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Feasibility of objectively measured physical activity and sedentary behavior in patients with malignant pleural effusion

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Abstract

Purpose

Malignant pleural effusion (MPE) affects 1 million people worldwide annually and can significantly impair physical activity. Accelerometry is a validated method of objectively assessing physical activity. The purpose of this study was to determine the compliance in patients with MPE to accelerometry and describe their activity.

Methods

Patients with MPE wore an Actigraph GT3X accelerometer over a 7-day continuous wear protocol. Compliance was measured as the percent of patients who had ≥4 valid days (i.e., 8-h/day of waking wear-time). Eastern Cooperative Oncology Group performance status was documented the day of actigraphy initialization.

Results

Forty-six patients with MPE received accelerometers; 44 (95.7%) returned their device. No complications were reported on their use. Forty subjects (90.9%) had ≥4 valid days of wear-time. Patients spent most of their waking hours sedentary [mean 11.0 h (SD 1.95)], with limited participation in moderate and vigorous physical activity [mean 9.5 min (SD 14.16)]. Compared to patients with better performance status (n = 32), patients with poorer performance status (n = 11) spent significantly more hours/day sedentary [mean difference 2.1 (CI 0.86–3.32); p = 0.001], as did those who survived <3 months (n = 5) compared to >12 months (n = 27) [mean difference 2.6 (CI 0.49–4.77); p = 0.013).

Conclusion

Accelerometry was applied successfully in patients with MPE with high compliance and no adverse events. This is the first reported objectively measured physical activity in patients with MPE and revealed high sedentary behavior and low physical activity. The data reflected patient performance status and discriminated between survival groups. Accelerometry can provide a useful measure for future interventional studies in patients with MPE.

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Acknowledgements

EJ receives an Australian Lung Foundation and Edith Cowan University PhD scholarship. YCGL is a National Health and Medical Research Council (NHMRC) of Australia Career Development Fellow and receives project grant funding from the NHMRC, New South Wales Dust Disease Board, Sir Charles Gairdner Research Advisory Committee, Lung Institute of Western Australia Westcare Alan King Grants, and the Cancer Council Western Australia. LS receives an NHMRC of Australia Senior Research Fellowship. CJM is supported by a Cancer Council Western Australia Postdoctoral Research Fellowship. The authors have full control of all primary data, which can be reviewed by the journal upon request

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Authors and Affiliations

  1. Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA, 6027, Australia

    Emily Jeffery, Robert U. Newton & Carolyn Peddle-McIntyre

  2. Respiratory Department, Sir Charles Gairdner Hospital, Nedlands, WA, Australia

    YC Gary Lee & Troy Wooding

  3. Institute for Respiratory Health, Nedlands, WA, Australia

    YC Gary Lee

  4. School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia

    YC Gary Lee

  5. School of Occupational Therapy and Social Work, Curtin University, Bentley, Australia

    Joanne McVeigh

  6. Exercise Laboratory, School of Physiology, University of Witwatersrand, Johannesburg, South Africa

    Joanne McVeigh

  7. School of Physiotherapy and Exercise Science, Curtin University, Bentley, Australia

    Leon Straker

  8. UQ Centre for Clinical Research, University of Queensland, St Lucia, Australia

    Robert U. Newton

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  1. Emily Jeffery
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Correspondence to Carolyn Peddle-McIntyre.

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Jeffery, E., Lee, Y., McVeigh, J. et al. Feasibility of objectively measured physical activity and sedentary behavior in patients with malignant pleural effusion. Support Care Cancer 25, 3133–3141 (2017). https://doi.org/10.1007/s00520-017-3721-9

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  • DOI: https://doi.org/10.1007/s00520-017-3721-9

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