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A prospective, observational, multicenter study on risk factors and prophylaxis for low emetic risk chemotherapy-induced nausea and vomiting

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Abstract

Purpose

The incidence of and the risk factors for nausea and vomiting in patients undergoing low emetic risk chemotherapy (LEC) are unclear. The aim of the study was to provide information on these topics by performing a multicenter, observational, prospective study.

Methods

The study consisted of patients who were administered first-time LEC that was consistent or inconsistent with current guidelines. Using the visual analog scale, patients recorded their daily food intake and the occurrence and severity of nausea over a 5-day treatment period.

Results

The overall incidence of chemotherapy-induced nausea and vomiting did not differ significantly between patients undergoing guideline-consistent (n = 89) or guideline-inconsistent (n = 121) prophylaxis (30.3 vs. 22.3%, respectively; P = 0.19). Logistic regression analysis identified a history of nausea and LEC other than taxanes as independent risk factors associated with nausea and vomiting in patients undergoing LEC. The mean daily visual analog scale scores for nausea severity and a decrease in food intake were <25 mm throughout the entire observation period.

Conclusions

Guideline-consistent prophylaxis appeared to control nausea and vomiting effectively in patients undergoing LEC. However, patients with a history of nausea and receiving LEC other than taxanes should be carefully observed and treatment should be adjusted according to their symptoms.

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Acknowledgments

We thank the study participants and their families and the support personnel. This study included the following 13 medical institutions: the National Kyushu Medical Center (Fukuoka, Fukuoka), National Kyushu Cancer Center (Fukuoka, Fukuoka), National Hospital Organization (NHO) Fukuoka National Hospital (Fukuoka, Fukuoka), NHO Kokura Medical Center (Kitakyushu, Fukuoka), NHO Saga National Hospital (Saga, Saga), NHO Ureshino Medical Center (Ureshino, Saga), NHO Nagasaki Medical Center (Omura, Nagasaki), NHO Kumamoto Medical Center (Kumamoto, Kumamoto), NHO Kumamoto Saishunso National Hospital (Koushi, Kumamoto), NHO Kumamoto Minami National Hospital (Uki, Kumamoto), NHO Beppu Medical Center (Beppu, Oita), NHO Miyakonojo Medical Center (Miyakonojo, Miyazaki), and NHO Kagoshima Medical Center (Kagoshima, Kagoshima).

Author information

Authors and Affiliations

  1. Department of Pharmacy, Clinical Research Institute, National Kyushu Medical Center, 1-8-1, Jigyohama, Chuo-ku, Fukuoka, 810-8563, Japan

    Toshinobu Hayashi & Makiko Koyabu

  2. Department of Pharmacy, National Kyushu Cancer Center, 3-1-1, Notame, Minami-ku, Fukuoka, 811-1395, Japan

    Toshinobu Hayashi

  3. Cancer Biostatistics Laboratory, Clinical Research Institute, National Kyushu Cancer Center, 3-1-1, Notame, Minami-ku, Fukuoka, 811-1395, Japan

    Mototsugu Shimokawa

  4. Department of Pharmacy, National Hospital Organization Beppu Medical Center, 1473 Uchikamado, Beppu, Oita, 874-0011, Japan

    Takanori Miyoshi & Yoko Toriyama

  5. Department of Pharmacy, National Hospital Organization Nagasaki Medical Center, 2-1001-1 Kubara, Omura, Nagasaki, 856-8562, Japan

    Chiaki Yokota

  6. Department of Pharmacy, National Hospital Organization Ureshino Medical Center, 2436 Oazashimojukuhei, Ureshino-cho, Ureshino, Saga, 843-0393, Japan

    Jun Taniguchi

  7. Department of Pharmacy, National Hospital Organization Kumamoto Saishunso National Hospital, 2659 Suya, Koushi, Kumamoto, 861-1196, Japan

    Kiyonori Hanada

  8. Department of Pharmacy, National Hospital Organization Miyakonojo Medical Center, 5033-1 Iwayoshi-cho, Miyakonojo, Miyazaki, 885-0014, Japan

    Kyouichi Tsumagari

  9. Department of Pharmacy, National Hospital Organization Kumamoto Medical Center, 1-5 Ninomaru, Chuo-ku, Kumamoto, 860-0008, Japan

    Noriko Okubo

  10. Department of Pharmacy, National Hospital Organization Fukuoka National Hospital, 1-39-4, Yakatabaru, Minami-ku, Fukuoka, 811-1394, Japan

    Yoshimichi Koutake

  11. Department of Pharmacy, National Hospital Organization Kumamoto South National Hospital, 2338 Toyofuku, Matsubase-cho, Uki, Kumamoto, 869-0593, Japan

    Kohei Sakata

  12. Department of Pharmacy, National Hospital Organization Kagoshima Medical Center, 8-1, Shiroyama-cho, Kagoshima, 892-0853, Japan

    Yosei Kawamata

  13. Department of Pharmacy, National Hospital Organization Kokura Medical Center, 10-1, Harugaoka, Kokuraminami-ku, Kitakyushu, 802-8533, Japan

    Takashi Goto

  14. Department of Pharmacy, National Hospital Organization Saga National Hospital, 1-20-1, Hinode, Saga, 849-8577, Japan

    Yasufumi Tsurusaki

Authors
  1. Toshinobu Hayashi
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  2. Mototsugu Shimokawa
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  3. Takanori Miyoshi
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  4. Yoko Toriyama
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  5. Chiaki Yokota
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  6. Jun Taniguchi
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  7. Kiyonori Hanada
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  8. Kyouichi Tsumagari
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  9. Noriko Okubo
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  10. Yoshimichi Koutake
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  11. Kohei Sakata
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  12. Yosei Kawamata
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  13. Takashi Goto
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  14. Yasufumi Tsurusaki
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  15. Makiko Koyabu
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Corresponding author

Correspondence to Toshinobu Hayashi.

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Conflicts of interest

The authors declare that they have no conflicts of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Funding source

This work was supported by the Policy-based Medical Service Foundation.

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Cite this article

Hayashi, T., Shimokawa, M., Miyoshi, T. et al. A prospective, observational, multicenter study on risk factors and prophylaxis for low emetic risk chemotherapy-induced nausea and vomiting. Support Care Cancer 25, 2707–2714 (2017). https://doi.org/10.1007/s00520-017-3679-7

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  • DOI: https://doi.org/10.1007/s00520-017-3679-7

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