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Comparison of efficacy of meperidine and fentanyl in terms of pain management and quality of life in patients with cervical cancer receiving intracavitary brachytherapy: a double-blind, randomized controlled trial

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Abstract

Objective

The aim of this study was to compare the effectiveness of two sedative regimens, a benzodiazepine with either meperidine or fentanyl, in relieving pain in patients with cervical cancer undergoing intracavitary brachytherapy in terms of pain score and quality of life.

Methods

Forty unselected outpatients undergoing brachytherapy (160 fractions) were enrolled with informed consent and randomized to receive a benzodiazepine with either meperidine or fentanyl. The perceived pain score according to a standard 10-item numeric rating scale was collected every 15 min during the procedure, and the perceived quality of life was determined at the end of each procedure using the EuroQol five-dimension questionnaire. The patients and medical staff members directly involved with the procedure were blinded to the medication used.

Results

The patients’ pain levels were mild in both analgesic groups. Meperidine appeared to be slightly more effective than fentanyl, although the differences in the average pain score and quality of life were not statistically significant.

Conclusion

Both meperidine and fentanyl in combination with benzodiazepine were effective in relieving pain and discomfort in patients undergoing brachytherapy.

Trial Registration

NCT02684942, ClinicalTrials.gov

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Acknowledgements

This study was supported by Chulabhorn Hospital.

Author information

Authors and Affiliations

  1. Department of Radiation Oncology, Chulabhorn Hospital, Chulabhorn Royal Academy, 54 Kamphang Phet 6 Rd, Lak Si, Bangkok, 10210, Thailand

    Saengrawee Thanthong, Sirikorn Rojthamarat, Danupon Nantajit & Nantakarn Ieumwananontachai

  2. Department of Anesthesiology, Chulabhorn Hospital, Chulabhorn Royal Academy, Bangkok, Thailand

    Wipra Worasawate

  3. Department of Anesthesiology, Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Phongthara Vichitvejpaisal

  4. Department of Radiology, Siriraj Hospital, Mahidol University, Bangkok, Thailand

    Nantakarn Ieumwananontachai

Authors
  1. Saengrawee Thanthong
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  2. Sirikorn Rojthamarat
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  3. Wipra Worasawate
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  4. Phongthara Vichitvejpaisal
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  5. Danupon Nantajit
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  6. Nantakarn Ieumwananontachai
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Corresponding author

Correspondence to Saengrawee Thanthong.

Ethics declarations

The study was approved by the Committee on Human Rights Related to Research Involving Human Subjects Chulabhorn Research Institute, number 20/2553. Written informed consent was obtained from all the patients.

Conflict of interest

The authors declare that they have no conflicts of interest.

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Thanthong, S., Rojthamarat, S., Worasawate, W. et al. Comparison of efficacy of meperidine and fentanyl in terms of pain management and quality of life in patients with cervical cancer receiving intracavitary brachytherapy: a double-blind, randomized controlled trial. Support Care Cancer 25, 2531–2537 (2017). https://doi.org/10.1007/s00520-017-3662-3

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  • DOI: https://doi.org/10.1007/s00520-017-3662-3

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