Abstract
Introduction
Symptom management in patients undergoing palliative chemotherapy is challenging, as patients may suffer from cancer symptoms as well as symptoms related to chemotherapy. Symptom clusters are interrelated symptoms occurring simultaneously that exert a negative impact on survival. Identification of symptom clusters and effective symptom management for patients receiving palliative chemotherapy is crucial.
Objectives
The purpose of this study was to identify symptom clusters among cancer patients undergoing palliative chemotherapy and examine the relationship between symptom clusters and functioning and quality of life (QOL) in these patients.
Methods
A total of 300 patients undergoing palliative chemotherapy participated in the study. Symptom experience during previous palliative chemotherapy was evaluated using a symptom questionnaire including 20 symptoms. The European Organization for Research and Treatment of Cancer Quality of Life-C30 was used to measure patients’ symptoms, functioning and QOL. Factor and hierarchical cluster analyses were performed to identify symptom clusters. Structural equation modeling was used to identify relationships between symptom clusters, functioning and QOL in patients.
Results
Four symptoms clusters including 14 symptoms were identified of the 20 symptoms experienced by patients undergoing palliative chemotherapy. The emotional cluster had negative influence on role and social functioning. The nausea and vomiting/appetite/taste change cluster had a negative impact on role functioning. The fatigue/cognitive and other cluster (dyspnea, pain, constipation, neuropathy, and sleep disturbance) negatively influenced physical functioning. Among the functioning subscales, only role functioning had a direct influence on QOL. Indirect relationships between symptom clusters and QOL were mediated by physical and role functioning. The final model, which consisted of four symptom clusters and three functioning subscales, accounted for 23.3% of the variance in the QOL.
Conclusions
Four symptom clusters occurring during palliative chemotherapy demonstrated negative influences on functioning and QOL. Differential contributions of symptom clusters to functioning were identified that eventually contributed to QOL through role functioning. The identified symptom clusters and their relationships with functioning and QOL may help guide approaches to symptom management. Implementation of interventions targeting symptom clusters would contribute to improving functioning and QOL in patients.
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References
Roeland EJ, LeBlanc TW (2016) Palliative chemotherapy: oxymoron or misunderstanding? BMC Palliat Care 15:33
Archer VR, Billingham LJ, Cullen MH (1999) Palliative chemotherapy: no longer a contradiction in terms. Oncologist 4:470–477
Kim HJ, McGuire DB, Tulman L, Barsevick AM (2005) Symptom clusters: concept analysis and clinical implications for cancer nursing. Cancer Nurs 28:270–282 quiz 283-274
Aktas A, Walsh D, Rybicki L (2012) Symptom clusters and prognosis in advanced cancer. Supportive Care in Cancer 20(11):2837–2843
Dong ST, Butow PN, Costa DS, Lovell MR, Agar M (2014) Symptom clusters in patients with advanced cancer: a systematic review of observational studies. J Pain Symptom Manag 48:411–450
Seow H, Barbera L, Sutradhar R, Howell D, Dudgeon D, Atzema C, Liu Y, Husain A, Sussman J, Earle C (2011) Trajectory of performance status and symptom scores for patients with cancer during the last six months of life. J Clin Oncol 29:1151–1158
Kim E, Jahan T, Aouizerat BE, Dodd MJ, Cooper BA, Paul SM, West C, Lee K, Swift PS, Wara W, Miaskowski C (2009) Differences in symptom clusters identified using occurrence rates versus symptom severity ratings in patients at the end of radiation therapy. Cancer Nurs 32:429–436
Dong ST, Costa DS, Butow PN, Lovell MR, Agar M, Velikova G, Teckle P, Tong A, Tebbutt NC, Clarke SJ, van der Hoek K, King MT, Fayers PM (2016) Symptom clusters in advanced cancer patients: an empirical comparison of statistical methods and the impact on quality of life. J Pain Symptom Manag 51:88–98
Van Lancker A, Beeckman D, Verhaeghe S, Van Den Noortgate N, Van Hecke A (2016) Symptom clustering in hospitalised older palliative cancer patients: a cross-sectional study. Int J Nurs Stud 61:72–81
Walsh D, Rybicki L (2006) Symptom clustering in advanced cancer. Support Care Cancer 14:831–836
Comrey AL, Lee HB (1992) A first course in factor analysis. Laurence Erlbaum Associates, Hillsdale, NJ
Raykov T, Marcoulides GA (2006) A first course in structural equation modeling. Laurence Erlbaum Associates, Mahwah, NJ
Henry DH, Viswanathan HN, Elkin EP, Traina S, Wade S, Cella D (2008) Symptoms and treatment burden associated with cancer treatment: results from a cross-sectional national survey in the U.S. Support Care Cancer 16:791–801
Akin S, Durna Z (2013) A comparative descriptive study examining the perceptions of cancer patients, family caregivers, and nurses on patient symptom severity in Turkey. Eur J Oncol Nurs 17:30–37
Molassiotis A, Brearley S, Saunders M, Craven O, Wardley A, Farrell C, Swindell R, Todd C, Luker K (2009) Effectiveness of a home care nursing program in the symptom management of patients with colorectal and breast cancer receiving oral chemotherapy: a randomized, controlled trial. J Clin Oncol 27:6191–6198
Cirillo M, Venturini M, Ciccarelli L, Coati F, Bortolami O, Verlato G (2009) Clinician versus nurse symptom reporting using the National Cancer Institute-common terminology criteria for adverse events during chemotherapy: results of a comparison based on patient’s self-reported questionnaire. Ann Oncol 20:1929–1935
Griffin AM, Butow PN, Coates AS, Childs AM, Ellis PM, Dunn SM, Tattersall MH (1996) On the receiving end. V: patient perceptions of the side effects of cancer chemotherapy in 1993. Ann Oncol 7:189–195
Sun CC, Bodurka DC, Weaver CB, Rasu R, Wolf JK, Bevers MW, Smith JA, Wharton JT, Rubenstein EB (2005) Rankings and symptom assessments of side effects from chemotherapy: insights from experienced patients with ovarian cancer. Support Care Cancer 13:219–227
Cleeland CS, Mendoza TR, Wang XS, Chou C, Harle MT, Morrissey M, Engstrom MC (2000) Assessing symptom distress in cancer patients: the M.D. Anderson symptom inventory. Cancer 89:1634–1646
Reeve BB, Mitchell SA, Dueck AC, Basch E, Cella D, Reilly CM, Minasian LM, Denicoff AM, O’Mara AM, Fisch MJ, Chauhan C, Aaronson NK, Coens C, Bruner DW (2014) Recommended patient-reported core set of symptoms to measure in adult cancer treatment trials. J Natl Cancer Inst 106
Portenoy RK, Thaler HT, Kornblith AB, Lepore JM, Friedlander-Klar H, Kiyasu E, Sobel K, Coyle N, Kemeny N, Norton L et al (1994) The memorial symptom assessment scale: an instrument for the evaluation of symptom prevalence, characteristics and distress. Eur J Cancer 30A:1326–1336
Rha SY, Song SK, Lee CE, Park Y, Lee J (2016) Gaps exist between patients’ experience and clinicians’ awareness of symptoms after chemotherapy: CINV and accompanying symptoms. Support Care Cancer
Yun YH, Park YS, Lee ES, Bang SM, Heo DS, Park SY, You CH, West K (2004) Validation of the Korean version of the EORTC QLQ-C30. Qual Life Res 13:863–868
Hu L, Bentler PM (1999) Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Struct Equ Model Multidiscip J 6:1–55
Thomas BC, Waller A, Malhi RL, Fung T, Carlson LE, Groff SL, Bultz BD (2014) A longitudinal analysis of symptom clusters in cancer patients and their sociodemographic predictors. J Pain Symptom Manag 47:566–578
Yennurajalingam S, Kwon JH, Urbauer DL, Hui D, Reyes-Gibby CC, Bruera E (2013) Consistency of symptom clusters among advanced cancer patients seen at an outpatient supportive care clinic in a tertiary cancer center. Palliat Support Care 11:473–480
Aktas A, Walsh D, Hu B (2014) Cancer symptom clusters: an exploratory analysis of eight statistical techniques. J Pain Symptom Manag 48:1254–1266
Ye ZJ, Liang MZ, Qiu HZ, Liu ML, GY H, Zhu YF, Zeng Z, Zhao JJ, Quan XM (2016) Effect of a multidiscipline mentor-based program, Be resilient to breast cancer (BRBC), on female breast cancer survivors in mainland China-a randomized, controlled, theoretically-derived intervention trial. Breast Cancer Res Treat 158:509–522
Pirri C, Bayliss E, Trotter J, Olver IN, Katris P, Drummond P, Bennett R (2013) Nausea still the poor relation in antiemetic therapy? The impact on cancer patients’ quality of life and psychological adjustment of nausea, vomiting and appetite loss, individually and concurrently as part of a symptom cluster. Support Care Cancer 21:735–748
Huang J, Gu L, Zhang L, Lu X, Zhuang W, Yang Y (2016) Symptom clusters in ovarian cancer patients with chemotherapy after surgery: a longitudinal survey. Cancer Nurs 39:106–116
Olver IN, Eliott JA, Koczwara B (2014) A qualitative study investigating chemotherapy-induced nausea as a symptom cluster. Support Care Cancer 22:2749–2756
Molassiotis A, Farrell C, Bourne K, Brearley SG, Pilling M (2012) An exploratory study to clarify the cluster of symptoms predictive of chemotherapy-related nausea using random forest modeling. J Pain Symptom Manag 44:692–703
Kim HJ, Barsevick AM, Tulman L, McDermott PA (2008) Treatment-related symptom clusters in breast cancer: a secondary analysis. J Pain Symptom Manag 36:468–479
Stapleton SJ, Holden J, Epstein J, Wilkie DJ (2016) Symptom clusters in patients with cancer in the hospice/palliative care setting. Support Care Cancer 24:3863–3871
Skerman HM, Yates PM, Battistutta D (2012) Cancer-related symptom clusters for symptom management in outpatients after commencing adjuvant chemotherapy, at 6 months, and 12 months. Support Care Cancer 20:95–105
Van Lancker A, Velghe A, Van Hecke A, Verbrugghe M, Van Den Noortgate N, Grypdonck M, Verhaeghe S, Bekkering G, Beeckman D (2014) Prevalence of symptoms in older cancer patients receiving palliative care: a systematic review and meta-analysis. J Pain Symptom Manag 47:90–104
Jordhoy MS, Fayers P, Loge JH, Saltnes T, Ahlner-Elmqvist M, Kaasa S (2001) Quality of life in advanced cancer patients: the impact of sociodemographic and medical characteristics. Br J Cancer 85:1478–1485
Acknowledgements
The current study was supported in part by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science, and Technology (2012R1A1A1010107 and 2015R1A1A1A05001342), in part by the Chungnam National University Research fund (2015-1728-01), and in part by the grant from the National R&D Program for Cancer Control, Ministry of Health and Welfare, Republic of Korea (1520190).
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The authors have no conflict of interest. They have full control of all primary data and agree to allow the journal to review their data if requested.
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An erratum to this article is available at http://dx.doi.org/10.1007/s00520-017-3705-9.
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Rha, S.Y., Lee, J. Symptom clusters during palliative chemotherapy and their influence on functioning and quality of life. Support Care Cancer 25, 1519–1527 (2017). https://doi.org/10.1007/s00520-016-3545-z
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DOI: https://doi.org/10.1007/s00520-016-3545-z