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Dietary intake variability in the cycle of cytotoxic chemotherapy

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Abstract

Purpose

This study was conducted to evaluate the dietary intake at different time points of the chemotherapeutic cycle.

Methods

Fifty-five ovarian cancer patients receiving at least 2 cycles of chemotherapy were deemed eligible for this study, of which 41 participants completed the study. Anthropometrical measurements and Subjective Global Assessment were used to estimate nutritional status. The dietary intake was evaluated by 3-day food records: 3 days prior to, the day of, and the following day after chemotherapy.

Results

Mean energy intake was the lowest on the day of chemotherapy and the highest 3 days before treatment (mean difference, 413.8 kcal; p < 0.001). Similarly, some vitamins and macro- and micronutrients (K, Ca, vit D, folate, vit C) failed to reach 50 % of the recommended dietary allowances. When dividing patients into BMI categories, the energy intake per kilogram of body weight, in the normal-weight patients, was statistically higher than that in overweight and obese subjects (23.6 vs. 20.9 vs. 12.3 kcal, respectively; p = 0.0015). Similarly, the statistically significant differences were observed by the intake of fats (0.80 vs. 0.69 vs. 0.39 g, p = 0.0283) and carbohydrates (3.52 vs. 3.05 vs. 1.71 g, p = 0.0004).

Conclusions

Dietary intake varies in the cycle of chemotherapy, with the lowest intake at the day of cytotoxic treatment and the highest before the next chemotherapy. Further studies evaluating dietary intake in patients undergoing chemotherapy should include in the protocol the exact time point of dietary assessment. The intake of energy, fats, and carbohydrates differs significantly across BMI categories.

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Acknowledgments

Thanks to Robert Tower, Ph.D., for providing language help for this manuscript.

Authors’ contribution

MM and MSM planned and conducted the research and wrote the manuscript; RM planned the research and commented on the manuscript.

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Authors and Affiliations

  1. Department of Human Nutrition and Hygiene, Poznan University of Life Science, Poznan, Poland

    Marcin Mardas

  2. Department of Oncology, Poznan University of Medical Sciences, Poznan, Poland

    Marcin Mardas & Radosław Mądry

  3. Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany

    Marta Stelmach-Mardas

  4. Department of Pediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland

    Marta Stelmach-Mardas

Authors
  1. Marcin Mardas
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  2. Radosław Mądry
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  3. Marta Stelmach-Mardas
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Corresponding author

Correspondence to Marta Stelmach-Mardas.

Ethics declarations

The study was performed in accordance with the Helsinki declaration; the subjects gave their written consent for the study.

Conflict of interest

The authors declare no conflict of interest and state that they have full control of all primary data and that they agree to allow the journal to review their data if requested.

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Mardas, M., Mądry, R. & Stelmach-Mardas, M. Dietary intake variability in the cycle of cytotoxic chemotherapy. Support Care Cancer 24, 2619–2625 (2016). https://doi.org/10.1007/s00520-015-3072-3

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  • DOI: https://doi.org/10.1007/s00520-015-3072-3

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