Functional benefits are sustained after a program of supervised resistance exercise in cancer patients with bone metastases: longitudinal results of a pilot study
Exercise may represent an effective adjunct therapy to current medical management strategies for maintaining functional independence and improving quality of life in cancer patients with bone metastatic disease. However, it has yet to be determined if there are any sustained effects following the completion of an exercise program by patients with bone metastases.
The aim of this study is to determine whether a 3-month supervised resistance exercise program results in any sustained functional benefits in prostate and breast cancer patients with bone metastatic disease.
Twenty men and women with bone metastatic disease secondary to prostate or breast cancer completed a 3-month supervised resistance exercise program followed by a 6-month observation period. Outcomes were assessed at baseline, post-exercise, and 6-month follow-up.
Fourteen participants completed the follow-up observation period. Significant improvements in physical function (4–6 %), physical activity levels (~160 min/week), lean mass (3–4 %), and quality of life (5–7 %) were observed at the completion of the exercise program. At the 6-month follow-up, significant improvements in ambulation (4 %), physical activity level (~105 min/week), whole body lean mass (2 %), and quality of life (13 %) remained.
An appropriately designed and supervised 3-month resistance exercise program may lead to significant improvements in functional ability, physical activity level, lean mass, and quality of life that remain 6 months after completion of the program in cancer patients with bone metastases. Future trials involving larger sample sizes are required to expand these preliminary findings.
KeywordsBone metastases Physical activity Advanced cancer Physical function
This study was funded by Cancer Council of Western Australia through the Early Career Investigator research grants program. PC is supported by the Cancer Council Western Australia Postdoctoral Research Fellowship. DAG is funded by a Movember New Directions Development Award obtained through Prostate Cancer Foundation of Australia's Research Program.
Conflict of interest
The authors have no conflicts of interest to disclose.
- 3.Bjorner JB, Wallenstein GV, Martin MC, Lin P, Blaisdell-Gross B, Tak Piech C, Mody SH (2007) Interpreting score differences in the SF-36 vitality scale: using clinical conditions and functional outcomes to define the minimally important difference. Curr Med Res Opin 23:731–739PubMedCrossRefGoogle Scholar
- 4.Borg G (1998) Borg's perceived exertion and pain scales. Human Kinetics, ChampaignGoogle Scholar
- 7.Cormie P, Newton RU, Spry N, Joseph D, Taaffe DR, Galvao DA (2013) Safety and efficacy of resistance exercise in prostate cancer patients with bone metastases Prostate Cancer and Prostatic Disease Aug 6 [Epub ahead of print]Google Scholar
- 10.Ferriolli E, Skipworth RJ, Hendry P, Scott A, Stensteth J, Dahele M, Wall L, Greig C, Fallon M, Strasser F, Preston T, Fearon KC (2012) Physical activity monitoring: a responsive and meaningful patient-centered outcome for surgery, chemotherapy, or radiotherapy? J Pain Symptom Manage 25 Jan [Epub ahead of print]Google Scholar
- 14.Galvao DA, Taaffe DR, Spry N, Joseph D, Newton RU (2010) Combined resistance and aerobic exercise program reverses muscle loss in men undergoing androgen suppression therapy for prostate cancer without bone metastases: a randomized controlled trial. J Clin Oncol 28:340–347PubMedCrossRefGoogle Scholar
- 16.Hechmati G, Cure S, Gouepo A, Hoefeler H, Lorusso V, Luftner D, Duran I, Garzon-Rodriguez C, Ashcroft J, Wei R, Ghelani P, Bahl A (2013) Cost of skeletal-related events in European patients with solid tumors and bone metastases: data from a prospective multinational observational study. J Med Econ 16:691–700PubMedCrossRefGoogle Scholar
- 29.National Cancer Institute (2009) Common Terminology Criteria for Adverse Events (CTCAE). U.S. Department of Health and Human Services, National Institute of Health, City, pp. 196Google Scholar
- 38.Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvao DA, Pinto BM, Irwin ML, Wolin KY, Segal RJ, Lucia A, Schneider CM, von Gruenigen VE, Schwartz AL (2010) American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 42:1409–1426PubMedCrossRefGoogle Scholar