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Treatment of acute and chronic focal neuropathic pain in cancer patients with lidocaine 5 % patches. A radiation and oncology department experience

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Abstract

Purpose

This study aims to evaluate the utility of a new technology, Lidocaine 5 % patch (L5%P), for providing analgesia without other sensory deficit in cancer patients with focal neuropathic pain (NP) related or not with cancer.

Methods

During the period February 2011 to July 2011, 83 patients were seen for the first time in our department and L5%P were prescribed to 15 of those patients (18.07 %). Information recorded in relation to the L5%P included the following: (a) Nature of NP, (b) medications tested, (c) drug combinations, (d) L5%P therapy duration, (e) efficacy, and (f) undesirable effects.

Results

Forty percent of the patients (n = 6) in our series had NP related to their cancer and 60 % (n = 9), chronic NP not related to their cancer diagnosis, but all referred to our Radiotherapy and Oncology Department for radiotherapy. The analgesic effect of the L5%P was potent in eight cases (53.33 %) and partial in four cases (26.66 %). This represents 79.99 % efficacy in selected patients. There were no serious adverse events reported in any of the patients.

Conclusion

The results indicate that there are patients with NP within a cancer setting who are suitable for treatment and successfully managed with topical L5%P, alone or in combination with other drugs.

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References

  1. Treede RD, Jensen TS, Campbell JN, Cruccu G, Dostrovsky JO, Griffin JW, Hansson P, Hughes R, Nurmikko T, Serra J (2008) Neuropathic pain: redefinition and grading system for clinical and research purposes. Neurology 70:1630–1635

    Article  PubMed  CAS  Google Scholar 

  2. Finnerup NB, Sindrup SH, Jensen TS (2010) Recent advances in pharmacological treatment of neuropathic pain. Med Rep 2:52–54

    Google Scholar 

  3. Cleeland CS, Farrar JT, Hausheer FH (2010) Assessment of cancer-related neuropathy and neuropathic pain. Oncologist 15(suppl 2):13–18

    Article  PubMed  Google Scholar 

  4. Caraceni A, Portenoy RK (1999) An international survey of cancer pain characteristics and syndromes. Pain 82:263–274

    Article  PubMed  CAS  Google Scholar 

  5. Fleming JA, O’Connor BD (2009) Use of lidocaine patches for neuropathic pain in a comprehensive cancer centre. Pain Res Manag 15:381–388

    Google Scholar 

  6. Fainsinger RL, Nekolaichuk CL, Lawlor PG, Neumann CM, Hanson J, Vigano A (2005) A multicenter study of the revised Edmonton Staging System for classifying cancer pain in advanced cancer patients. J Pain Symptom Manag 29:224–237

    Article  Google Scholar 

  7. Lema MJ, Foley KM, Hausherr FH (2010) Types and epidemiology of cancer-related neuropathic pain: the intersection of cancer pain and neuropathic pain. Oncologist 15(suppl 2):3–8

    Article  PubMed  Google Scholar 

  8. National Comprehensive Cancer Network (2009) NCCN clinical practice guidelines. Adult Cancer Pain 1, Available at http://www.nccn.org/professinals/physician_gls/PDF/pain.pdf. Accessed 19 Feb 2010

  9. Urch CE, Dickenson AH (2008) Neuropathic pain in cancer. Eur J Cancer 44:1091–1096

    Article  PubMed  CAS  Google Scholar 

  10. Finnerup NB, Otto M, McQuay HJ, Jensen TS, Sindrup SH (2005) Algorithm for neuropathic pain treatment: an evidence based proposal. Pain 118:289–305

    Article  PubMed  CAS  Google Scholar 

  11. Dworkin RH, O’Connor AB, Backonja M, Farrar JT, Finnerup NB, Jensen TS, Kalso EA, Loeser JD, Miaskowski C, Nurmikko TJ, Portenoy RK, Rice AS, Stacey BR, Treede RD, Turk DC, Wallace MS (2007) Pharmacologic management of neuropathic pain: evidence based recommendations. Pain 132:237–251

    Article  PubMed  CAS  Google Scholar 

  12. Baron R, Mayoral V, Leijon G, Binder A, Steigerwald I, Serpell M (2009) 5 % Lidocaine medicated plaster versus pregabalin in postherpetic neuralgia and diabetic polyneuropathy: an open-label, non-inferiority two-stage RCT study. Curr Med Res Opin 25:1663–1676

    Article  PubMed  CAS  Google Scholar 

  13. Pérez C, Gálvez R, Huelbes S, Insausti J, Boyhassira D, Díaz S et al (2007) Validity and reliability of the Spanish version of the DN4 (Douleur Neuropathique 4 questions) questionnaire for differential diagnosis of pain syndromes associated to a neuropathic or somatic component. Health Qual Life Outcomes 5:66

    Article  PubMed  Google Scholar 

  14. Persaud N, Strichartz GR (2002) Micromolar lidocaine selectively blocks propagating ectopic impulses at a distance from their site of origin. Pain 99:333–340

    Article  PubMed  CAS  Google Scholar 

  15. Chow E, Wu JS, Hoskin P et al (2002) International consensus on palliative radiotherapy endpoints for future clinical trials in bone metastases. Radiother Oncol 64:275–280

    Article  PubMed  Google Scholar 

  16. Brennan F, Carr DB, Cousins M (2007) Pain management: a fundamental human right. Anesth Analg 105:205–221

    Article  PubMed  Google Scholar 

  17. Hausherr FH, Schilsky RL, Bain S et al (2006) Diagnosis, management, and evaluation of chemotherapy-induced peripheral neuropathy. Semin Oncolo 33:15–49

    Article  Google Scholar 

  18. Jost L, Roila F (2009) ESMO guidelines working group. Management of cancer pain: ESMO clinical recommendations. Ann Oncol 20(suppl 4):170–173

    PubMed  Google Scholar 

  19. Comer AM, Lamb HM (2000) Licocaine patch 5 %. Drugs 59:245–249

    Article  PubMed  CAS  Google Scholar 

  20. Campbell BJ, Rowbotham M, Davies PS, Jacob P III, Benowitz NL (2002) Systemic absorption of topical lidocaine in normal volunteers, patients with post-herpetic neuralgia, and patients with acute herpes zoster. J Pharm Sci 91:1343–1350

    Article  PubMed  CAS  Google Scholar 

  21. Sinnot C (2002) Problems recruiting cancer patients to a comparative clinical trial of drug treatments for neuropathic pain in palliative care. J Pain Symptom Manag 23:270–272

    Article  Google Scholar 

  22. Meier T, Wasner G, Faust M et al (2003) Efficacy of lidocaine patch 5 % in the treatment of focal peripheral neuropathic pain syndromes: A randomized double-blind, placebo-controlled study. Pain 106:151–158

    Article  PubMed  CAS  Google Scholar 

  23. Galer BS (2002) Effectiveness and safety of lidocaine patch 5 %. J Fam Pract 51:867–868

    PubMed  Google Scholar 

  24. Nalamachu S, Crockett RS, Mathur D (2006) Lidocaine patch 5 for carpal tunnel syndrome: how it compares with injections: a pilot study. J Fam Pract 55:209–214

    PubMed  Google Scholar 

  25. Kehlet H, Jensen TS, Woolf CJ (2006) Persistent postsurgical pain: risk factors and prevention. Lancet 367:1618–1625

    Article  PubMed  Google Scholar 

  26. Cheville AL, Sloan JA, Northfelt DW et al (2009) Use of a lidocaine patch in the management of postsurgical neuropathic pain in patients with cancer: a phase III double-blind crossover study (NO1CB). Support Care Cancer 17:451–460

    Article  PubMed  Google Scholar 

  27. Lin PL, Fan SZ, Huang CH et al (2008) Analgesic effect of lidocaine patch 5 % in the treatment of acute herpes zoster: a double-blind and vehicle-controlled study. Reg Anesth Pain Med 33:320–325

    PubMed  CAS  Google Scholar 

  28. Mackley CL, Marks JG Jr, Anderson BE (2003) Delayed-type hypersensitivity to lidocaine. Arch Dermatol 139:343–346

    Article  PubMed  Google Scholar 

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Conflicts of interest

The author declares that she has no conflicts of interest relating to the publication of this manuscript. She has no relationship with any organisation. No organisation has sponsored this research.

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Authors and Affiliations

  1. Radiation Oncology Department, ONCOSUR, Clínica Inmaculada Concepción, Granada, Spain

    Escarlata López Ramírez

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  1. Escarlata López Ramírez
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Correspondence to Escarlata López Ramírez.

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López Ramírez, E. Treatment of acute and chronic focal neuropathic pain in cancer patients with lidocaine 5 % patches. A radiation and oncology department experience. Support Care Cancer 21, 1329–1334 (2013). https://doi.org/10.1007/s00520-012-1670-x

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  • DOI: https://doi.org/10.1007/s00520-012-1670-x

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