A systematic review of the effect of low-level laser therapy in the management of breast cancer-related lymphedema
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The purpose of this study was to review the effect of low-level laser therapy (LLLT) in the management of breast cancer-related lymphedema (BCRL).
A systematic review of seven databases for clinical trials for LLLT in the management of BCRL published between 1990 and 2011 was performed.
A total of eight studies on 230 patients were found. The methodological qualities of the selected studies were assessed with the Physiotherapy Evidence Database scale, and the studies were categorized according to Sackett’s levels of evidence. Five studies were graded at evidence level II. Two studies were graded at evidence level III, and the remaining study was graded at evidence level V.
There is moderate to strong evidence for the effectiveness of LLLT for the management of BCRL from five small studies of acceptable methodological quality. A dose of 1–2 J/cm2 per point applied to several points covering the fibrotic area can reduce limb volume following BCRL. Further well-designed, large-scale studies are required to determine more precisely how effective LLLT may be in BCRL.
KeywordsBreast cancer Lymphedema Low-level laser therapy
Conflict of interest
- 7.Soran A, D’Angelo G, Begovic M, Ardic F, Harlak A, Samuel Wieand H et al (2006) Breast cancer-related lymphedema—what are the significant predictors and how they affect the severity of lymphedema? Breast J12:536–543Google Scholar
- 8.Casley-Smith JR, Casley-Smith JR (1994) Volume alterations in lymphedema; untreated, and after complex therapy (C.P.T), benzo-pyrones, or both. Lymphology 27(suppl):627–631Google Scholar
- 19.Casley-Smith J, Casley-Smith JR (1997) The cost efficiencies of various treatments for lymphoedema. In: Casley-Smith J, Casley-Smith JR (eds) Modern treatment for lymphoedema. The Lymphedema Association of Australia, Adelaide, pp 296–304Google Scholar
- 30.Lievens PC (1985) The influence of laser-irradiation on the motoricity of the lymphatic system and on the wound healing process. In: Proceedings from the International Congress on Laser in Medicine and Surgery, Bologna, 26–28 June: 171–4Google Scholar
- 31.Lievens PC (1991) The effect of combined HeNe and I.R. laser treatment on the regeneration of the lymphatic system during the process of wound healing. Lasers Med Sci 6:93–99Google Scholar
- 32.Cormier J, Feldman J, Askew A, Beck M, Bernas M, Francis K et al (2010) ALFP to update the best practice document. J Lymphedema 5:68–71Google Scholar
- 35.Se S, Richardson WS, Glasziou P, Haynes RB (2002) Evidence based medicine: how to practice and teach EBM, 3rd edn. Elsevier Churchill Livingstone, EdinburghGoogle Scholar
- 40.Bobyd S, Brooks D, Agnew-Coughlin J, Ashwell J (1994) Evaluation of the literature on the effectiveness of physical therapy modalities in the management of children with cystic fibrosis. Pediatr Phys Ther 6:70–74Google Scholar
- 44.Oasevich IA, Shargorodskii AG (1999) Low intensity infrared laser in the diagnosis and combined treatment of acute non-specific lymphadenitis of the face and neck in children. Stomatologia 78:28–30Google Scholar