Abstract
Eleven advanced cancer patients affected by malignant bowel obstruction (MBO) were treated at home with a combination of octreotide, metoclopramide, morphine, and dexamethasone. In all patients, we observed a prompt control of gastrointestinal symptoms and recovery of bowel movements within 1–5 days. Based on our results, a combination of drugs with different mechanisms of action allows an effective and safe treatment for MBO at home. Further studies with larger number of patients are warranted to confirm these preliminary data.
References
Mercadante S, Ferrera P, Villari P et al (2004) Aggressive pharmacological treatment for reversing malignant bowel obstruction. J Pain Symptom Manage 28:412–416
Maltoni M, Nanni O, Pirovano M et al (1999) Successful validation of the palliative prognostic score in terminally ill cancer patients. Italian multicentric study group on palliative care. J Pain Symptom Manage 17:240–247
Ripamonti C, Twycross R, Baines M et al (2001) Clinical-practice recommendations for the management of bowel obstruction in patients with end-stage cancer. Supp Care Cancer 9:223–233
Ripamonti C, Bruera E (2002) Palliative mangement of malignant bowel obstruction. Int J Gynecol Cancer 12:135–143
Anonymous (2006) The challenge of treating malignant bowel ostruction. J Support Oncol 4:83–84
Ripamonti CI, Eassson AM, Gerdes H (2008) Management of malignant bowel obstruction. Eur J Cancer 44:1005–1015
Mercadante S (1995) Tolerability of continous subcutaneous ocreotide used in combination with other drugs. J Palliat Care 11:1s4
Mercadante S (1995) Bowel obstruction in home-care patients: 4 years experience. Support Care Cancer 3:190–193
Mercadante S, Ripamonti C, Casuccio A et al (2000) Comparison of octreotide and hyoscine butylbromide in controlling gastrointestinal symptoms due to malignant inoperable bowel obstruction. Supp Care Cancer 8:188–191
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Porzio, G., Aielli, F., Verna, L. et al. Can malignant bowel obstruction in advanced cancer patients be treated at home?. Support Care Cancer 19, 431–433 (2011). https://doi.org/10.1007/s00520-010-1009-4
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DOI: https://doi.org/10.1007/s00520-010-1009-4