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Radiological imaging change in a malignant bowel obstruction patient treated with octreotide

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Abstract

Introduction

Malignant bowel obstruction (MBO) is a complication in advanced cancer patients with abdominal and pelvic malignancy. Recent research has established the efficacy of octreotide for MBO-related symptom relief. The mechanism that octreotide increases water absorption in case of MBO has not been demonstrated except for experimental animal and normal human model.

Case report

We present a 60-year-old man with pancreatic cancer and MBO treated with octreotide. Radiological imaging showed the disappearance of large-volume fluid retention in the small intestine with alleviating vomiting within 2 days. This radiological change might result from the effect of octreotide increasing water absorption in intestine tract.

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References

  1. Feuer DJ, Broadley KE (2000) Corticosteroids for the resolution of malignant bowel obstruction in advanced gynaecological and gastrointestinal cancer. Cochrane Database Syst Rev 2:CD001219

    PubMed  Google Scholar 

  2. Guiro FF, Bertolini G, Salas JV (1999) Improvement in the intestinal processes of hydroelectrolytic absorption and secretion in abdominal pathologies of surgical interest treated with SMS 201–995: experimental protocol. Surg Today 29:419–430

    Article  PubMed  CAS  Google Scholar 

  3. Hogenauer C, Aichbichler B, Santa AC, Porter J, Fordtran J (2002) Effect of octreotide on fluid absorption and secretion by the normal human jejunum and ileum in vivo. Aliment Pharmacol Ther 16:769–777

    Article  PubMed  CAS  Google Scholar 

  4. Mercadante S (1995) Diarrhea in terminally ill patients: pathophysiology and treatment. J Pain Symptom Manage 10:298–309

    Article  PubMed  CAS  Google Scholar 

  5. Mercadante S, Casuccio A, Mangione S (2007) Medical treatment for inoperable malignant bowel obstruction: a qualitative systematic review. J Pain Symptom Manage 33:217–223

    Article  PubMed  CAS  Google Scholar 

  6. Mercadante S, Ripamonti C, Casuccio A, Zecca E, Groff L (2000) Comparison of octreotide and hyoscine butylbromide in controlling gastrointestinal symptoms due to malignant inoperable bowel obstruction. Support Care Cancer 8:188–191

    Article  PubMed  CAS  Google Scholar 

  7. Mystakidou K, Tsilika E, Kalaidopoulou O, Chondros K, Georgaki S, Papadimitriou L (2002) Comparison of octreotide administration vs. conservative treatment in the management of inoperable bowel obstruction in patients with far advanced cancer: a randomized, double-blind, controlled clinical trial. Anticancer Res 22:1187–1192

    PubMed  CAS  Google Scholar 

  8. Philip J, Depczynski B (1997) The role of total parenteral nutrition for patients with irreversible bowel obstruction secondary to gynecological malignancy. J Pain Symptom Manage 13:104–111

    Article  PubMed  CAS  Google Scholar 

  9. Ripamonti C (2006) Bowel obstruction. In: Textbook of palliative medicine A Hodder Arnold Publication, London, pp 588–600

  10. Ripamonti C, Easson A, Gerdes H (2008) Management of malignant bowel obstruction. Eur J Cancer 44:1105–1115

    Article  PubMed  Google Scholar 

  11. Ripamonti C, Mercadante S (2004) Pathophysiology and management of malignant bowel obstruction. In: Oxford textbook of palliative medicine 3rd ed. Oxford University Press, New York, pp 496–506

  12. Ripamonti C, Mercadante S, Groff L, Zecca E, De Conno F, Casuccio A (2000) Role of octreotide, scopolamine butylbromide, and hydration in symptom control of patients with inoperable bowel obstruction and nasogastric tubes: a prospective, randomized trial. J Pain Symptom Manage 19:23–34

    Article  PubMed  CAS  Google Scholar 

  13. Sykes N (2004) Constipation and diarrhoea In: Oxford textbook of palliative medicine 3rd ed. Oxford University Press, New York, pp 483–496

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Correspondence to Takuya Shinjo.

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Shinjo, T., Kagami, R. Radiological imaging change in a malignant bowel obstruction patient treated with octreotide. Support Care Cancer 17, 753–755 (2009). https://doi.org/10.1007/s00520-009-0608-4

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  • DOI: https://doi.org/10.1007/s00520-009-0608-4

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