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Social support and survival in patients with acute myeloid leukaemia

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Abstract

Goal of work

The purpose of the study was to assess the effect of the reported availability of social support on the 2-year survival of patients with acute myelogenous leukaemia (AML).

Materials and methods

Fifty patients with newly diagnosed AML were asked to rate the level of available social support after diagnosis was made, but before the start of chemotherapy. Social support was assessed with the F-SozU, and information about confounding variables (age, functional status, intensity of chemotherapy, cytogenetic risk group) was collected. Univariate and multivariate Cox regression analyses were used to analyze predictors of 2-year survival.

Main results

Higher levels of available social support predicted better survival, even after controlling for age, functional status, dosage of chemotherapy, and cytogenetic risk group. Within social support, the availability of instrumental support showed more consistent associations with 2-year survival than the availability of emotional support.

Conclusions

For patients with AML, the availability of social support is relevant for decreased mortality, after accounting for age, functional impairment, dosage of chemotherapy and cytogenetic risk group.

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References

  1. Alferi SM, Carver CS, Antoni MH, Weiss S, Duran RE (2001) An exploratory study of social support, distress, and life disruption among low-income Hispanic women under treatment for early stage breast cancer. Health Psychol 20:41–46

    Article  PubMed  CAS  Google Scholar 

  2. Andersen BL, Kiecolt-Glaser JK, Glaser R (1994) A biobehavioral model of cancer stress and disease course. Am Psychol 49:389–404

    Article  PubMed  CAS  Google Scholar 

  3. Butow PN, Coates AS, Dunn SM (1999) Psychosocial predictors of survival in metastatic melanoma. J Clin Oncol 17:3856–3860

    Google Scholar 

  4. Byrd JC, Mrozek K, Dodge RK, Carroll AJ, Edward CG, Arthur DC et al (2002) Pretreatment cytogenetic abnormalities are predictive of induction success, cumulative incidence of relapse, and overall survival in adult patients with de novo acute myeloid leukaemia: results from Cancer and Leukaemia Group B (CALGB 8461). Blood 100:4325–4336

    Article  PubMed  CAS  Google Scholar 

  5. Caplan RD, Robinson EA, French JR, Caldwell JR, Shinn M (1976) Adhering to medical regimes: pilot experiments in patient education and social support. University of Michigan, Ann Arbor, MI

    Google Scholar 

  6. Colon EA, Callies AL, Popkin MK, McClave PB (1991) Depressed mood and other variables related to bone marrow transplantation survival in acute leukaemia. Psychosomatics 32:420–425

    PubMed  CAS  Google Scholar 

  7. Cox DR (1972) Regression models and life tables. J R Stat Soc 34:187–220

    Google Scholar 

  8. Cwinkel JG, Behar LC, Zabora JR (1997) Psychosocial factors that affect the survival of adult cancer patients: a review of research. J Psychosoc Oncol 15(3/4):1–34

    Article  Google Scholar 

  9. DeBoer MF, Ryckman RM, Pruyn JF, Van den Borne HW (1999) Psychosocial correlates of cancer relapse and survival: a literature review. Patient Educ Couns 37:215–230

    Article  CAS  Google Scholar 

  10. Dukes Holland K, Holahan CK (2003) The relation of social support and coping to positive adaptation to breast cancer. Psychol health 18:15–29

    Article  Google Scholar 

  11. Duric V, Stockler M (2001) Patients’ preferences for adjuvant chemotherapy in early breast cancer: a review of what makes it worthwhile. Lancet Oncol 2:691–697

    Article  PubMed  CAS  Google Scholar 

  12. Ell K, Nishimoto R, Mediansky L, Mantell J, Hamlovitch M (1992) Social relations, social support and survival among patients with cancer. J Psychosom Res 36:531–541

    Article  PubMed  CAS  Google Scholar 

  13. Fawzy FI, Fawzy NW, Hyun CS, Elashoff R, Guthrie D, Fahey JL, Morton DL (1993) Malignant melanoma. Effects of an early structured psychiatric intervention, coping, and affective state on recurrence and survival 6 years later. Arch Gen Psychiatry 50:681–689

    PubMed  CAS  Google Scholar 

  14. Frick E, Motzke C, Fischer N, Busch R, Bumeder I (2005) Is perceived social support a predictor of survival for patients undergoing autologous peripheral blood stem cell transplantation? Psychooncology 14:759–770

    Article  PubMed  CAS  Google Scholar 

  15. Fydrich T, Geyer M, Hessel A, Sommer G, Brähler E (1999) Fragebogen zur Sozialen Unterstützung (F-SozU): Normierung an einer repräsentativen Stichprobe [Social support questionnaire (F-SozU): norms of a representative sample]. Diagnostica 45:212–216

    Article  Google Scholar 

  16. Giraldi T, Rodani MG, Cartei G, Grassi L (1997) Psychosocial factors and breast cancer: A 6-year follow-up study. Psychother Psychosom 66:229–236

    Article  PubMed  CAS  Google Scholar 

  17. Goodwin JS, Samet JM, Hunt WC (1996) Determinants of survival in older cancer patients. J Natl Cancer Inst 88:1031–1038

    Article  PubMed  CAS  Google Scholar 

  18. Grimwade D, Harrison H, Oliver F, Chatters S, Harrison CJ, Wheatley K et al (2001) The predictive value of hierarchical cytogenetic classification in older adults with acute myeloid leukaemia (AML): analysis of 1065 patients entered into the United Kingdom Medical Research Council AML11 trial. Blood 98:1312–1320

    Article  PubMed  CAS  Google Scholar 

  19. Grulke N, Bailer H, Hartenstein B, Kächele H, Arnold B, Tschuschke V, Heimpel H (2005) Coping and survival in patients with leukaemia undergoing allogeneic bone marrow transplantation — long-term follow-up of a prospective study. J Psychosom Res 59:337–346

    Article  PubMed  Google Scholar 

  20. Helgeson VA, Cohen S, Fritz HL (1998) Social ties and cancer. In: Holland JC (ed) Psycho-oncology. Oxford University Press, New York, pp 99–109

    Google Scholar 

  21. Hwang SS, Chang VT, Cogswell J, Aljano Y, Osenenko P, Morales E, Srinivas S, Kasimis B (2004) Study of unmet needs in symptomatic veterans with advanced cancer: incidence, independent predictors, and unmet needs outcome model. J Pain Symptom Manage 28:421–432

    Article  PubMed  Google Scholar 

  22. Kimby E, Nygren P, Glimelius B (2001) A systematic overview of chemotherapy effects in acute myeloid leukaemia. Acta Oncol 40:231–252

    Article  PubMed  CAS  Google Scholar 

  23. Kiss A, Meryn S (2001) Effect of sex and gender on psychosocial aspects of prostate and breast cancer. Br Med J 323:1056–1058

    Article  Google Scholar 

  24. Kogon MM, Biswas A, Pearl D, Carlson EW, Spiegel D (1997) Effects of medical and psychotherapeutic treatment on the survival of women with metastatic breast cancer. Cancer 80:225–230

    Article  PubMed  CAS  Google Scholar 

  25. Kuchler T, Henne-Bruns D, Rappat S, Graul J, Holst K, Williams JI, Wood-Dauphinee S (1999) Impact of psychotherapeutic support on gastrointestinal cancer patients undergoing surgery: survival results of a trial. Hepatogastroenterology 46:322–335

    PubMed  CAS  Google Scholar 

  26. Levy SM, Herberman BR, Whiteside T, Sanzo K, Lee J, Kirkwood J (1990) Perceived social support and tumor estrogen/progesterone receptor status as predictors of natural killer cell activity in breast cancer patients. Psychosom Med 52:73–85

    PubMed  CAS  Google Scholar 

  27. Maunsell E, Brisson J, Deschenes L (1995) Social support and survival among women with breast cancer. Cancer 76:631–637

    Article  PubMed  CAS  Google Scholar 

  28. Mrózek K, Heininen K, Bloomfield CD (2000) Prognostic value of cytogenetic findings in adults with acute myeloid leukaemia. Int J Hematol 72:261–271

    PubMed  Google Scholar 

  29. Nannya Y, Kanda Y, Oshima K, Kaneko M, Yamamoto R, Chizuka A et al (2002) Prognostic factors in elderly patients with acute myelogenous leukaemia: a single center study in Japan. Leuk Lymphoma 43:83–87

    Article  PubMed  Google Scholar 

  30. Naughton MJ, Herndon JE, Shumaker SA, Miller AA, Kornblith AB, Chao D, Holland J (2002) The health-related quality of life and survival of small-cell lung cancer patients: results of a companion study to CALGB 9033. Qual Life Res 11:235–248

    Article  PubMed  CAS  Google Scholar 

  31. Osborne RH, Sali A, Aaronson NK, Elsworth GR, Mdzewski B, Sinclair AJ (2004) Immune function and adjustment style: do they predict survival in breast cancer. Psychooncology 13:199–210

    Article  PubMed  Google Scholar 

  32. Perera G, Domingo A, Villamor N, Palacious C, Junca J, Torres P, Llorente A, Fernandez C, Tormo M, de Llano MP, Bargay J, Gallart M, Florensa L, Vivancos P, Marti JM, Font L (2005) Adverse prognostic impact of CD36 and CD2 expression in adult de novo acute myeloid leukemia patients. Leuk Res 29:1109–1116

    Article  CAS  Google Scholar 

  33. Pettigrew M, Bell R, Hunter D (2003) Influence of psychological coping on survival and recurrence in people with cancer: Systematic review. Br Med J 325:1066–1076

    Article  Google Scholar 

  34. Pieto JM, Atala J, Blanch J, Carreras E, Rovira M, Cirera E, Espinal A, Gastro C (2005) Role of depression as a predictor of mortality among cancer patients after stem-cell transplantation. J Clin Oncol 23:5878–5880

    Article  Google Scholar 

  35. Reynolds P, Kaplan GA (1990) Social connections and risk for cancer: Prospective evidence from the Alameda County Study. Behav Med 16:101–110

    Article  PubMed  CAS  Google Scholar 

  36. Rumpold G, Augustin M, Zschocke I, Strittmatter G, Söllner W (2001) Die Validität des Hornheider Fragebogens zur psychosozialen Unterstützung bei Tumorpatienten [The validity of the Hornheide Questionnaire for psychosocial support in tumor patients]. Psychother Psychosom Med Psychol 51:25–33

    Article  PubMed  CAS  Google Scholar 

  37. Sanson-Fisher R, Girgis A, Boyes A, Bonevski B, Burton L, Cook P (2000) The unmet support care needs of patients with cancer. Cancer 88:226–237

    Article  PubMed  CAS  Google Scholar 

  38. SEER Surveillance Epidemiology and End Results. Available at http://seer.cancer.gov/

  39. Sommer G, Fydrich T (1989) Soziale Unterstützung: diagnostik, Konzepte, F-SOZU. Deutsche Gesellschaft für Verhaltenstherapie, Tübingen

  40. Soothill K, Morris SM, Harman J, Francis B, Thomas C, McIllmuray MB (2001) The significant unmet needs of cancer patients: probing psychosocial concerns. Support Care Cancer 9:597–605

    Article  PubMed  CAS  Google Scholar 

  41. Spataro V, Kovacsovich T, Bach S, Pampallona S, Schapira M, Cavalli F (2000) Acute myeloid leukaemia in the elderly: results of an individualized approach in two centres. Leuk Lymphoma 39:521–530

    PubMed  CAS  Google Scholar 

  42. Stavratsky KM, Donner AP, Kincade JE, Stewart MA (1988) The effect of psychosocial factors on lung cancer mortality at one year. J Clin Epidemiol 41:75–82

    Article  Google Scholar 

  43. Turner-Cobb JM, Stephton SE, Koopman C, Blake-Mortimer J, Spiegel D (2000) Social support and salivary cortisol in women with metastatic breast cancer. Psychosom Med 62:337–345

    PubMed  CAS  Google Scholar 

  44. Vigano A, Bruera E, Jhangri GS, Newman SC, Fields AL, Suarez-Almazor ME (2000) Clinical survival predictors in patients with advanced cancer. Arch Intern Med 160:861–868

    Article  PubMed  CAS  Google Scholar 

  45. Vogt TM, Mulloly JP, Ernst D, Pope CR, Hollis JF (1992) Social networks as predictors of ischemic heart disease, cancer, stroke, and hypertension: Incidence, survival and mortality. J Clin Epidemiol 45:659–666

    Article  PubMed  CAS  Google Scholar 

  46. Waxler-Morrison N, Hislop TG, Mears B, Kan L (1991) Effects of social relationships on survival for women with breast cancer: a prospective study. Soc Sci Med 33:177–183

    Article  PubMed  CAS  Google Scholar 

  47. Weihs KL, Simmens SJ, Mizrahi J, Enright TM, Hunt ME, Siegel RS (2005) Dependable social relationships predict overall survival in stages II and II breast carcinoma patients. J Psychosom Res 59:299–306

    Article  PubMed  Google Scholar 

  48. Wong R, Shahajahan M, Wang X, Thall PF, De Lima M, Khouri I et al (2005) Prognostic factors for outcomes of patients with refractory or relapsed acute myelogenous leukaemia or myelodysplastic syndromes undergoing allogeneic progenitor cell transplantation. Biol Blood Marrow Transplant 11:108–114

    Article  PubMed  Google Scholar 

  49. World Health Organization (1979) WHO handbook for reporting results of cancer treatment. WHO, Geneva

    Google Scholar 

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Acknowledgement

The study was supported by the German Cancer Aid (Deutsche Krebshilfe), grant 70-2445-Hö3.

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Correspondence to Martin Pinquart.

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Pinquart, M., Höffken, K., Silbereisen, R.K. et al. Social support and survival in patients with acute myeloid leukaemia. Support Care Cancer 15, 81–87 (2007). https://doi.org/10.1007/s00520-006-0114-x

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