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Higher incidence of chemotherapy induced oral mucositis in females: a supplement of multivariate analysis to a randomized multicentre study

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Study on the normal saline vs povidone–iodine mouthwashes for oral mucositis (OM) prophylaxis in patients after high-dose chemotherapy comprising bischloroethyl nitrosourea etoposide ara-C melphalan (BEAM) or high-dose melphalan (HD-L-PAM) followed by autologous peripheral stem cell transplantation indicated that females have higher a incidence of OM compared to men, as reported by [Vokurka et al. 13:554–558, (2005)]. The multivariable analysis of larger cohort of 148 patients compliant with the original study protocol confirmed female gender to be an independent risk factor and predictor for OM. The HD-L-PAM (200 mg/m2) conditioning regimen revealed to be more toxic compared to BEAM as for incidence of OM grades 3–4 World Health Organization score. Body mass index, age, mouthwash solution used, and CD34+ cell number in the autologous graft were verified not to have an impact on OM incidence in this group of patients.

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We highly acknowledge the assistance of K. Steinerova, M.D., F.Šefrna, RNDr., I. Chvojková, V. Kaslová (Plzen), J. Vítková (Olomouc), J. Maslová (Hradec Králové), P. Horvathová, V. Jarolíková, R. Micheliová (Bratislava), J. Bocková (Kosice), A. Kalocayová, E. Karliková, S. Kerestenyová, S. Gyurkyová and S. Statianová (Bánská Bystrica).

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Correspondence to Samuel Vokurka.

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Vokurka, S., Bystrická, E., Koza, V. et al. Higher incidence of chemotherapy induced oral mucositis in females: a supplement of multivariate analysis to a randomized multicentre study. Support Care Cancer 14, 974–976 (2006).

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