Acupuncture and acupressure for the prevention of chemotherapy-induced nausea—a randomised cross-over pilot study
- 642 Downloads
To investigate whether a combination of acupuncture and acupressure is effective for reducing chemotherapy-induced nausea and vomiting.
Patients and methods
In a randomised cross-over trial, 28 patients receiving moderately or highly emetogenic chemotherapy and conventional standard antiemesis were treated for one chemotherapy cycle with a combination of acupuncture and acupressure at point P6 and for one cycle at a close sham point. The main outcome measure was a nausea score derived from daily intensity rating.
There was no difference between combined acupuncture and acupressure treatment at P6 and at the sham point for the nausea score, but the level of nausea was very low in both phases. The mean nausea score was 6.2 (standard deviation 9.0) for treatment at P6 and 6.3 (9.1) for treatment at the sham point (mean difference −0.1, 95% confidence interval −3.9 to 3.7; p=0.96). Seventeen of 21 participants completing the study would desire acupuncture and acupressure for future chemotherapy cycles, but there was no clear preference for either point.
In this small pilot study a significant difference between treatment at P6 and a close sham point could not be detected. However, it cannot be ruled out that an existing difference was missed due to the small sample size.
KeywordsNausea Emesis Acupuncture Chemotherapy Randomised controlled trial
The authors would like to thank Li Li for performing acupuncture in the trial. The study was realised without external funding from the resources of the Centre for Complementary Medicine Research. Acupressure bands were kindly supplied by Hop GmbH, Haibach, Germany.
- 2.Gralla RJ, Osoba D, Kris MG, Kirkbride P, Hesketh PJ, Chinnery LW, Clark-Snow R, Gill DP, Groshen S, Grunberg S, Koeller JM, Morrow GR, Perez EA, Silber JH, Pfister DG (1999) Recommendations for the use of antiemetics: evidence-based, clinical practice guidelines. J Clin Oncol 17:2971–2994PubMedGoogle Scholar
- 6.Morrow GR (1992) A patient report measure for the quantification of chemotherapy induced nausea and emesis: psychometric properties of the Morrow assessment of nausea and emesis (MANE). Br J Cancer 66 (Suppl XIX):S72–S74Google Scholar
- 7.Roscoe JA, Morrow GR, Hickock JT, Bushunow P, Pierce HI, Flynn PJ, Kirshner JJ, Moore DF, Atkins JN (2003) The efficacy of acupressure and acustimulation wrist bands for the relief of chemotherapy-induced nausea and vomiting. A University of Rochester cancer center community clinical oncology program multicenter study. J Pain Symptom Manage 26:731–742CrossRefPubMedGoogle Scholar
- 9.Streitberger K, Friedrich-Rust M, Bardenheuer H, Unnebrink K, Windeler J, Goldschmidt H, Egerer G (2003) Effect of acupuncture compared with placebo-acupuncture at P6 as additional antiemetic prophylaxis in high-dose chemotherapy and autologous peripheral blood stem cell transplantation: a randomized controlled single-blind trial. Clin Cancer Res 9:2539–2544Google Scholar