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Fatigue patterns and correlates in male liver cancer patients receiving transcatheter hepatic arterial chemoembolization

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Abstract

Liver cancer is a leading cancer in Taiwan, especially in males. Transcatheter arterial chemoembolization (TACE) is a major treatment for these patients, but research examining their fatigue experiences is limited. The purposes of this longitudinal, correlational study were to identify (1) changes in fatigue, symptom distress, anxiety and depression in cancer patients across four time points during the first week of TACE treatment, and (2) factors predicting changes in fatigue across the four time points. Eligible male inpatients with liver cancer were recruited from a medical center in Taipei. Subjects (n=40) were assessed 1 day before (T1), and during days 2 (T2), 4 (T3) and 6 (T4) of TACE. Data were analyzed by descriptive statistics, Pearson’s correlations, repeated measures analysis of variance (ANOVA) and the generalized estimating equation (GEE). Subjects had mild to moderate levels of fatigue that peaked at T2, and showed a decrease at T3 and T4 but were still slightly higher than at T1. The GEE analysis showed that greater symptom distress, anxiety and depression, higher Adriamycin dosage, longer duration of previous fatigue, and less education significantly predicted fatigue changes. The results indicate that the pattern of fatigue in TACE during the first week is similar to fatigue in patients receiving chemotherapy. The results also further indicate that fatigue is associated to several factors. The causal relationships between fatigue and these related factors should be examined. Interventions targeting these factors should also be tested in future studies.

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Acknowledgement

This study was partly supported by a grant from the National Science Council in Taiwan. The authors gratefully acknowledge the support and assistance of the patients who participated in this study. The authors also thank Claire Baldwin for her English editing.

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Authors and Affiliations

  1. College of Nursing, University of Utah, Salt Lake City, Utah, USA

    Shiow-Ching Shun

  2. Graduate Institute of Nursing, Taipei Medical University, 250 Wu-Hsing Street, 110, Taipei, Taiwan

    Yeur-Hur Lai, Chii Jeng & Sue-Yueh Cheng

  3. Department of Nursing, Taipei Veterans General Hospital, Taipei, Taiwan

    Ting-Ting Jing & Li-Shia Hu

  4. Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan

    Fa-Yau Lee

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  1. Shiow-Ching Shun
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  2. Yeur-Hur Lai
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  4. Chii Jeng
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  5. Fa-Yau Lee
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  7. Sue-Yueh Cheng
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Correspondence to Yeur-Hur Lai.

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Shun, SC., Lai, YH., Jing, TT. et al. Fatigue patterns and correlates in male liver cancer patients receiving transcatheter hepatic arterial chemoembolization. Support Care Cancer 13, 311–317 (2005). https://doi.org/10.1007/s00520-004-0740-0

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  • DOI: https://doi.org/10.1007/s00520-004-0740-0

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