Abstract
Hypercalcemia of malignancy remains a common metabolic complication of advanced cancer often resulting in considerable morbidity and diminishing life quality in the later stages of disease. Bisphosphonates, especially zoledronic acid, are potent inhibitors of bone resorption and are the most effective therapy for hypercalcemia of malignancy. We report on the course of disease in a 51-year-old woman who presented with metastatic breast cancer that had relapsed to the liver. The patient suffered from a pamidronate-refractory paraneoplastic hypercalcemia, which caused a confused mental status and compromised her already severely limited life quality. Only with the introduction of zoledronate could the patient’s hypercalcemia be normalized with consecutive regain of an acceptable life quality.
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References
Berenson JR (2002) Treatment of hypercalcemia of malignancy with bisphosphonates. Semin Oncol 29 [Suppl 21]:12–18
Green JR, Müller K, Jaeggi KA (1994) Preclinical pharmacology of CGP 42‘446, a new, potent, heterocyclic bisphosphonate compound. J Bone Miner Res 9:745–751
Green JR, Seltenmeyer Y, Jaeggi KA, Widler L (1997) Renal tolerability profile of novel, potent bisphosphonates in two-short term rat models. Pharmacol Toxicol 80:225–230
Karnofsky DA, Abelman WH, Craver LF, Burchenal JH (1948) The use of nitrogen mustards in the palliative treatment of carcinoma. Cancer 1:634–656
Major P, Lortholary A, Hon J, Abdi E, Mills G, Menssen HD, Yunus F, Bell R, Body J, Quebe-Fehling E, Seaman J (2001) Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: A pooled analysis of two randomized, controlled clinical trials. J Clin Oncol 19:558–567
Ralston SH, Gallacher SJ, Patel U, et al (1990) Cancer-associated hypercalcemia: Morbidity and mortality. Ann Intern Med 112:499–504
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Wenzel, C., Bartsch, R., Hussian, D. et al. Zoledronate in a patient with pamidronate refractory hypercalcemia syndrome. Support Care Cancer 12, 678–681 (2004). https://doi.org/10.1007/s00520-004-0645-y
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DOI: https://doi.org/10.1007/s00520-004-0645-y