The treatment of lymphedema related to breast cancer: a systematic review and evidence summary
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Goals of work
To provide an evidence summary report on the question: What are the treatment options for women with lymphedema following treatment for breast cancer?
Cancer Care Ontario’s Supportive Care Guidelines Group (SCGG) employed systematic review methodology to produce an evidence summary on this topic. Evidence-based opinions were formulated to guide clinical decision making, and a formal external review process was conducted to validate the relevance of these opinions for Ontario practitioners.
The systematic review search strategy identified ten randomized controlled trials which form the basis of this evidence summary report. Four key opinions offered by the SCGG are outlined below. Responses from the practitioner feedback process supported the validity of these opinions in Ontario. (1) There is some evidence to suggest that compression therapy and manual lymphatic drainage may improve established lymphedema, but further studies are needed. Compression garments should be worn from morning to night and be removed at bedtime. Patients should be advised that lymphedema is a lifelong condition and that compression garments must be worn on a daily basis. Patients can expect stabilization and/or modest improvement of edema with the use of the garment in the prescribed fashion. (2) There is no current evidence to support the use of medical therapies, including diuretics. (3) Additional efforts to define relevant clinical outcomes for the assessment of patients with lymphedema would be valuable. (4) These opinions are appropriate for patients with more than mild lymphedema, where the signs and symptoms are considered significant from the patients’ perspective.
KeywordsLymphedema Breast neoplasms Systematic review Evidence summary Lymphedema management
- 2.Badger C, Seers K, Preston N, et al (2002) Physical therapies for reducing and controlling lymphoedema of the limbs (Protocol for a Cochrane Review). In: The Cochrane Library, issue 2. Update Software, OxfordGoogle Scholar
- 3.Bertelli G, Venturini M, Forno G, et al (1991) Conservative treatment of postmastectomy lymphedema: a controlled, randomized trial. Ann Oncol 2:575–578Google Scholar
- 6.Browning C (1997) The management of lymphoedema. In: Redman S, Pillar C, Turner J, Boyle F (eds) Lymphoedema: prevalence, risk factors and management: a review of research. NHMRC National Breast Cancer Centre, SydneyGoogle Scholar
- 8.Dini D, Del Mastro L, Gozz A, et al (1998) The role of pneumatic compression in the treatment of postmastectomy lymphedema. A randomized phase III study. Ann Oncol 9:187–191Google Scholar
- 13.Hornsby R (1995) The use of compression to treat lymphoedema. Prof Nurs 11:127–128Google Scholar
- 14.Howell D, Ezzo J, Tuppo K, et al (2002) Complete decongestive therapy for lymphedema following breast cancer treatment (Protocol for a Cochrane Review). In: The Cochrane Library, issue 2. Update Software, OxfordGoogle Scholar
- 18.Kissin MW, Querci della Roveret G, Easton D, et al (1986) Risk of lymphoedema following the treatment of breast cancer. Br J Surg 73:680–684Google Scholar
- 23.Oncology Nursing Society (1998) Manual for radiation oncology nursing practice and education. Oncology Nursing Press, Pittsburgh, PA (summary at http://www.ons.org/xp6/ONS/Library.xml/ONS_Publications.xml/Book_Excerpts.xml/ManualRadiationOncology/FrontPage.xml)Google Scholar
- 24.Pain SJ, Purushotham AD (2000) Lymphoedema following surgery for breast cancer. Br J Surg 87:1128–1141Google Scholar
- 25.Pecking A, Lasry S, Boudinet A, et al (1988) Post surgical physiotherapeutic treatment: interest in secondary upper limb lymphedemas prevention. Prog Lymphology 11:562–564Google Scholar
- 30.Scottish Intercollegiate Guidelines Network (1998) Breast cancer in women (publication no. 29). http://www.show.scot.nhs.uk/sign/guidelines/fulltext/29/index.htmlGoogle Scholar