Skip to main content
Log in

Sedentary behavior and kidney function in adults: a narrative review

  • review article
  • Published:
Wiener klinische Wochenschrift Aims and scope Submit manuscript

Summary

There is increasing evidence for an association between SB and CKD, an emerging public health problem particularly affecting old people. For this reason a systematic literature search was carried out in Embase and PubMed (Jan 2000–Dec 2018) looking for an association between SB and kidney function. A total of 10 studies met the inclusion criteria (7 cross-sectional and 3 longitudinal investigations). A sedentary lifestyle was positively and independently of several confounders related to an impaired kidney function (chronic kidney disease or decrease of glomerular filtration rate), particularly in cross-sectional studies; however, more studies are needed to further establish the current evidence and to explore the exact independent mechanisms of sedentary behavior in relation to kidney function. Due to the inconsistency of the few longitudinal studies, future investigations are required to explore if SB is prospectively associated with a higher risk of developing CKD.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Go AS, Chertow GM, Fan D, McCulloch CE, Hsu CY. Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 2004;351:1296–305.

    CAS  PubMed  Google Scholar 

  2. Chrysohoou C, Panagiotakos DB, Pitsavos C, Skoumas J, Toutouza M, Papaioannou I, et al. Renal function, cardiovascular disease risk factors’ prevalence and 5‑year disease incidence; the role of diet, exercise, lipids and inflammation markers: the ATTICA study. QJM. 2010;103:413–22.

    CAS  PubMed  Google Scholar 

  3. Jha V, Garcia-Garcia G, Iseki K, Li Z, Naicker S, Plattner B, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;382:260–72.

    PubMed  Google Scholar 

  4. Webster AC, Nagler EV, Morton RL, Masson P. Chronic kidney disease. Lancet. 2017;389:1238–52.

    PubMed  Google Scholar 

  5. Levey AS, Becker C, Inker LA. Glomerular filtration rate and albuminuria for detection and staging of acute and chronic kidney disease in adults: a systematic review. JAMA. 2015;313:837–46.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Albright A, Franz M, Hornsby G, Kriska A, Marrero D, Ullrich I, et al. American college of sports medicine position stand. Exercise and type 2 diabetes. Med Sci Sports Exerc. 2000;32:1345–60.

    CAS  PubMed  Google Scholar 

  7. Pescatello LS, Franklin BA, Fagard R, Farquhar WB, Kelley GA, Ray CA, et al. American college of sports medicine position stand. Exercise and hypertension. Med Sci Sports Exerc. 2004;36:533–53.

    PubMed  Google Scholar 

  8. Centers for Disease Control and Prevention (CDC). Prevalence of chronic kidney disease and associated risk factors—United States, 1999–2004. MMWR Morb Mortal Wkly Rep. 2007;56:161–5.

    Google Scholar 

  9. Zelle DM, Klaassen G, van Adrichem E, Bakker SJ, Corpeleijn E, Navis G. Physical inactivity: a risk factor and target for intervention in renal care. Nat Rev Nephrol. 2017;13:152–68.

    PubMed  Google Scholar 

  10. Owen N, Sparling PB, Healy GN, Dunstan DW, Matthews CE. Sedentary behavior: emerging evidence for a new health risk. Mayo Clin Proc. 2010;85:1138–41.

    PubMed  PubMed Central  Google Scholar 

  11. Katzmarzyk PT, Janssen I. The economic costs associated with physical inactivity and obesity in Canada: an update. Can J Appl Physiol. 2004;29:90–115.

    PubMed  Google Scholar 

  12. Chenoweth D, Leutzinger J. The economic cost of physical inactivity and excess weight in American adults. J Phys Act Health. 2006;3:148–63.

    PubMed  Google Scholar 

  13. van der Ploeg HP, Chey T, Korda RJ, Banks E, Bauman A. Sitting time and all-cause mortality risk in 222 497 Australian adults. Arch Intern Med. 2012;172:494–500.

    PubMed  Google Scholar 

  14. Tremblay MS, Aubert S, Barnes JD, Saunders TJ, Carson V, Latimer-Cheung AE, et al. Sedentary behavior research network (SBRN)—terminology consensus project process and outcome. Int J Behav Nutr Phys Act. 2017;14:75.

    PubMed  PubMed Central  Google Scholar 

  15. Wells GA, Shea B, O’Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. 2014.

    Google Scholar 

  16. Levey AS, Coresh J, Greene T, Stevens LA, Zhang YL, Hendriksen S, et al. Using standardized serum creatinine values in the modification of diet in renal disease study equation for estimating glomerular filtration rate. Ann Intern Med. 2006;145:247–54.

    CAS  PubMed  Google Scholar 

  17. Levey AS, Stevens LA, Schmid CH, Zhang YL, Castro AF 3rd, Feldman HI, et al. A new equation to estimate glomerular filtration rate. Ann Intern Med. 2009;150:604–12.

    PubMed  PubMed Central  Google Scholar 

  18. Lynch BM, White SL, Owen N, Healy GN, Chadban SJ, Atkins RC, et al. Television viewing time and risk of chronic kidney disease in adults: the AusDiab study. Ann Behav Med. 2010;40:265–74.

    PubMed  Google Scholar 

  19. Bharakhada N, Yates T, Davies MJ, Wilmot EG, Edwardson C, Henson J, et al. Association of sitting time and physical activity with CKD: a cross-sectional study in family practices. Am J Kidney Dis. 2012;60:583–90.

    PubMed  Google Scholar 

  20. Lee S, Shimada H, Lee S, Makizako H, Doi T, Harada K, et al. Association between sedentary time and kidney function in community-dwelling elderly Japanese people. Geriatr Gerontol Int. 2017;17:730–6.

    PubMed  Google Scholar 

  21. Hawkins M, Newman AB, Madero M, Patel KV, Shlipak MG, Cooper J, et al. TV watching, but not physical activity, is associated with change in kidney function in older adults. J Phys Act Health. 2015;12:561–8.

    PubMed  Google Scholar 

  22. Hawkins MS, Sevick MA, Richardson CR, Fried LF, Arena VC, Kriska AM. Association between physical activity and kidney function: national health and nutrition examination survey. Med Sci Sports Exerc. 2011;43:1457–64.

    PubMed  Google Scholar 

  23. Parsons TJ, Sartini C, Ash S, Lennon LT, Wannamethee SG, Lee IM, et al. Objectively measured physical activity and kidney function in older men; a cross-sectional population-based study. Age Ageing. 2017;46:1010–4.

    PubMed  PubMed Central  Google Scholar 

  24. Glavinovic T, Ferguson T, Komenda P, Rigatto C, Duhamel TA, Tangri N, et al. CKD and sedentary time: results from the Canadian health measures survey. Am J Kidney Dis. 2018;72:529–37.

    PubMed  Google Scholar 

  25. Martens RJH, van der Berg JD, Stehouwer CDA, Henry RMA, Bosma H, Dagnelie PC, et al. Amount and pattern of physical activity and sedentary behavior are associated with kidney function and kidney damage: the Maastricht study. PLoS One. 2018;13:e195306.

    PubMed  PubMed Central  Google Scholar 

  26. Guo VY, Brage S, Ekelund U, Griffin SJ, Simmons RK, ADDITION-Plus study team. Objectively measured sedentary time, physical activity and kidney function in people with recently diagnosed type 2 diabetes: a prospective cohort analysis. Diabet Med. 2016;33:1222–9.

    CAS  PubMed  Google Scholar 

  27. McClellan WM, Abramson J, Newsome B, Temple E, Wadley VG, Audhya P, et al. Physical and psychological burden of chronic kidney disease among older adults. Am J Nephrol. 2010;31:309–17.

    PubMed  PubMed Central  Google Scholar 

  28. Carrero JJ, Hecking M, Chesnaye NC, Jager KJ. Sex and gender disparities in the epidemiology and outcomes of chronic kidney disease. Nat Rev Nephrol. 2018;14:151–64.

    PubMed  Google Scholar 

  29. Rockey DC, Bell PD, Hill JA. Fibrosis—a common pathway to organ injury and failure. N Engl J Med. 2015;373:96.

    PubMed  Google Scholar 

  30. Wynn TA. Cellular and molecular mechanisms of fibrosis. J Pathol. 2008;214:199–210.

    CAS  PubMed  PubMed Central  Google Scholar 

  31. Duffield JS. Cellular and molecular mechanisms in kidney fibrosis. J Clin Invest. 2014;124:2299–306.

    CAS  PubMed  PubMed Central  Google Scholar 

  32. Smyth LJ, Duffy S, Maxwell AP, McKnight AJ. Genetic and epigenetic factors influencing chronic kidney disease. Am J Physiol Renal Physiol. 2014;307:F757–76.

    CAS  PubMed  Google Scholar 

  33. Finkelstein J, Joshi A, Hise MK. Association of physical activity and renal function in subjects with and without metabolic syndrome: a review of the third national health and nutrition examination survey (NHANES III). Am J Kidney Dis. 2006;48:372–82.

    PubMed  Google Scholar 

  34. Jafar TH, Jin A, Koh WP, Yuan JM, Chow KY. Physical activity and risk of end-stage kidney disease in the Singapore Chinese health study. Nephrology (Carlton). 2015;20:61–7.

    Google Scholar 

  35. Bertrais S, Beyeme-Ondoua JP, Czernichow S, Galan P, Hercberg S, Oppert JM. Sedentary behaviors, physical activity, and metabolic syndrome in middle-aged French subjects. Obes Res. 2005;13:936–44.

    PubMed  Google Scholar 

  36. Dunstan DW, Salmon J, Owen N, Armstrong T, Zimmet PZ, Welborn TA, et al. Physical activity and television viewing in relation to risk of undiagnosed abnormal glucose metabolism in adults. Diabetes Care. 2004;27:2603–9.

    PubMed  Google Scholar 

  37. Dunstan DW, Salmon J, Owen N, Armstrong T, Zimmet PZ, Welborn TA, et al. Associations of TV viewing and physical activity with the metabolic syndrome in Australian adults. Diabetologia. 2005;48:2254–61.

    CAS  PubMed  Google Scholar 

  38. Ford ES, Kohl HW 3rd, Mokdad AH, Ajani UA. Sedentary behavior, physical activity, and the metabolic syndrome among U.S. adults. Obes Res. 2005;13:608–14.

    PubMed  Google Scholar 

  39. Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, et al. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol. 2007;27:2650–6.

    CAS  PubMed  PubMed Central  Google Scholar 

  40. Hamilton MT, Healy GN, Dunstan DW, Zderic TW, Owen N. Too little exercise and too much sitting: inactivity physiology and the need for new recommendations on sedentary behavior. Curr Cardiovasc Risk Rep. 2008;2:292–8.

    PubMed  PubMed Central  Google Scholar 

  41. Yates T, Khunti K, Wilmot EG, Brady E, Webb D, Srinivasan B, et al. Self-reported sitting time and markers of inflammation, insulin resistance, and adiposity. Am J Prev Med. 2012;42:1–7.

    PubMed  Google Scholar 

  42. Demiot C, Dignat-George F, Fortrat JO, Sabatier F, Gharib C, Larina I, et al. WISE 2005: chronic bed rest impairs microcirculatory endothelium in women. Am J Physiol Heart Circ Physiol. 2007;293:H3159–64.

    CAS  PubMed  Google Scholar 

  43. Carter S, Hartman Y, Holder S, Thijssen DH, Hopkins ND. Sedentary behavior and cardiovascular disease risk: mediating mechanisms. Exerc Sport Sci Rev. 2017;45:80–6.

    PubMed  Google Scholar 

  44. Volaklis K, Thorand B, Peters A, Halle M, Margot H, Amann U, et al. Muscular strength is independently associated with cystatin-C: the KORA-age study. Int J Sports Med. 2018;39(3):225–31.

    CAS  PubMed  Google Scholar 

  45. Diaz KM, Howard VJ, Hutto B, Colabianchi N, Vena JE, Sattford MM, et al. Patterns of sedentary behavior and mortality in U.S. middle-aged and older adults: a national cohort study. Ann Intern Med. 2017;167:465–75.

    PubMed  PubMed Central  Google Scholar 

  46. Winjidaele K, Brage S, Besson H, Khaw KT, Sharp SJ, Luben R, et al. Television viewing time independently predicts all-cause and cardiovascular mortality: the EPIC Norfolk study. Int J Epidemiol. 2011;40:150–9.

    Google Scholar 

  47. Pandey A, Sallahuddin U, Garg S, Ayers C, Kulinski J, Anand V, et al. Continuous dose-response association between sedentary time and risk for cardiovascular disease: a meta-analysis. JAMA Cardiol. 2016;1:575–83.

    PubMed  Google Scholar 

  48. Raman M, Middleton RJ, Kaira PA, Green D. Estimating renal function in old people: an in-depth review. Int Urol Nephrol. 2017;49(11):1979–88.

    PubMed  PubMed Central  Google Scholar 

  49. Garcia JM, Duran AT, Schwartz JE, Booth JN, Hooker SP, Willey JZ, et al. Types of sedentary behavior and risk of cardiovascular events and mortality in blacks: the Jackson heart study. J Am Heart Assoc. 2019;8(13):e10406.

    PubMed  PubMed Central  Google Scholar 

  50. Ciccone J, Woodruff SJ, Fryer K, Campell T. Associations among evening snacking, screen time, weight status, and overall diet quality in young adolescents. Appl Physiol Nutr Metab. 2013;38:789–94.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Konstantinos Volaklis Ph.D..

Ethics declarations

Conflict of interest

K. Volaklis, T. Mamadjanov, and C. Meisinger declare that they have no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Volaklis, K., Mamadjanov, T. & Meisinger, C. Sedentary behavior and kidney function in adults: a narrative review. Wien Klin Wochenschr 133, 144–152 (2021). https://doi.org/10.1007/s00508-020-01673-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00508-020-01673-2

Keywords

Navigation