Different clinical effect of several types of airborne allergens on the severity of bronchial hyperreactivity

  • Slavomír Perečinský
  • Marek Varga
  • Jozefína Petrovičová
  • Ondrej Ragač
  • Katarína Perečinská
  • Andrea Jančová
  • Lenka Murínová
  • Tomáš Bačinský
  • L’ubomír Legáth
original article

DOI: 10.1007/s00508-017-1220-0

Cite this article as:
Perečinský, S., Varga, M., Petrovičová, J. et al. Wien Klin Wochenschr (2017). doi:10.1007/s00508-017-1220-0

Summary

Background

Atopic sensitization belongs to the most common risk factors for bronchial asthma. However, in clinical practice, it is not clear whether sensitization against pollen and perennial allergens is differently associated with the severity of bronchial hyperresponsiveness (BHR).

Aim

To find out whether patients sensitized to perennial allergens differ in severity of bronchial hyperresponsiveness from patients sensitized to pollen allergens.

Methods

The study includes 109 patients. Based on the results of skin prick tests, patients were divided into three groups: sensitivity to pollen allergens – group A; sensitivity to perennial allergens – group B; sensitivity to both pollen and perennial allergens – group C. Based on the histamine bronchoprovocation test, we compared the values of histamine provocative concentration causing a 20% drop in FEV1 (PC20) among particular groups of patients. Mild bronchial hyperresponsiveness was determined if the value of PC20 was >4 mg/ml, while if the value of PC20 was <4 mg/ml, the bronchial hyperresponsiveness was considered as moderate/severe.

Results

A statistically significant difference was found in the degrees of bronchial hyperresponsiveness between the three groups of patients, namely, group A with the patients sensitized only to the pollen allergens, group B comprising patients sensitized to the perennial allergens only, and group C, involving patients sensitized to the combination of both pollen and perennial allergens. The PC20 values were higher among the patients from the group A (7.46 mg/ml) compared to group B (4.25 mg/ml) and C (4.52 mg/ml). The odds ratio for moderate/severe BHR was 5.21 and 5.04 in group B and group C, respectively.

Conclusion

Severity of bronchial hyperresponsiveness shows differences according to sensitization to particular allergens. Perennial allergens are more often associated with serious forms of bronchial hyperresponsiveness which also have an impact on the severity and prognosis of bronchial asthma.

Keywords

Bronchial asthma Bronchial hyperresponsiveness Allergic sensibilization Pollen allergens Perennial allergens 

Copyright information

© Springer-Verlag Wien 2017

Authors and Affiliations

  • Slavomír Perečinský
    • 1
  • Marek Varga
    • 1
  • Jozefína Petrovičová
    • 2
  • Ondrej Ragač
    • 3
  • Katarína Perečinská
    • 1
  • Andrea Jančová
    • 1
  • Lenka Murínová
    • 1
  • Tomáš Bačinský
    • 4
  • L’ubomír Legáth
    • 1
  1. 1.Department of Occupational Medicine and Clinical Toxicology, Medical FacultyPavol Jozef Safarik University and the L. Pasteur University HospitalKosiceSlovakia
  2. 2.Department of Medical Informatics, Medical FacultyPavol Jozef Safarik UniversityKosiceSlovakia
  3. 3.Institute of Virology, Biomedical Research CenterSlovak Academy of ScienceBratislavaSlovakia
  4. 4.Department of Mathematical Methods and Managerial Informatics, Faculty of ManagementUniversity of PresovPresovSlovakia

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