Summary
In Central Europe, reports of human envenomation by Cheiracanthium punctorium, commonly known as the yellow sac spider, are sporadic, despite the fact that this species is widespread in Europe. However, in recent years, C. punctorium has been repeatedly described globally in medical and toxicological literature. Its venom was found to possess insecticidal, haemolytic, cytotoxic, and membrane-damaging activities. Its bite is often very painful, frequently associated with local and transient cutaneous and neurotoxic effects, but sometimes also with systemic symptoms which require medical help. The main objective of this article is to introduce more details about C. punctorium, the clinical manifestations and circumstances of its bite, the characteristics of its venom and proposed clinical management. The authors provide case reports of patients bitten by C. punctorium during the 10-year observational period. All patients presented in this article showed generally mild clinical manifestations and recovered completely without sequelae. No further treatment in terms of hospital surveillance or specific clinical measures was necessary in any of the reported cases.
Similar content being viewed by others
References
World Spider Catalog. World Spider Catalog. Natural History Museum Bern. Version 17.5 2017. http://wsc.nmbe.ch. Accessed 6 Jan 2017.
Vassilevski AA, Fedorova IM, Maleeva EE, et al. Novel class of spider toxin: active principle from the yellow sac spider Cheiracanthium punctorium venom is a unique two-domain polypeptide. J Biol Chem. 2010;285(42):32293–302. doi:10.1074/jbc.m110.1042.
Nentwig W, Gnädinger M, Fuchs J, Ceschi A. A two year study of verified spider bites in Switzerland and a review of the European spider bite literature. Toxicon. 2013;73:104–10.
Krehenwinkel H, Rödder D, Nǎpǎruş M, Kuntner M. Rapid genetic and ecological differentiation during the northern range expansion of the venomous yellow sac spider Cheiracanthium punctorium in Europe. Evol Appl. 2016;9:1229–40.
Papini R. Documented bites by a yellow sac spider (Cheiracanthium punctorium) in Italy: a case report. J Venom Anim Toxins Incl Trop Dis. 2012;18(3):349–54.
Kostanjšek R, Kuntner M. Araneae Sloveniae: a national spider species checklist. Zookeys. 2015;21(474):1–91.
Sachkova MY, Slavokhotova AA, Grishin EV, Vassilevski AA. Structure of the yellow sac spider Cheiracanthium punctorium genes provides clues to evolution of insecticidal two-domain knottin toxins. Insect Mol Biol. 2014;23(4):527–38. doi:10.1111/imb.12097.
Diaz JH. The global epidemiology, syndromic classification, management, and prevention of spider bites. Am J Trop Med Hyg. 2004;71(2):239–50.
Gnädinger M, Nentwig W, Fuchs J, Ceschi A. Swiss prospective study on spider bites. Swiss Med Wkly. 2013;143:w13877. doi:10.4414/smw.2013.13877.
Divito SJ, Haught JM, English JC III, Ferris LK. An extensive case of dermonecrotic arachinidism. J Clin Aesthet Dermatol. 2009;2(9):40–3.
Kostanjšek R, Celestina A. New records on synanthropic spider species (Arachnida: Araneae) in Slovenia. Nat Slov. 2008;10(1):51–5.
Vetter RS, Isbister GK, Bush SP, Boutin LJ. Verified bites by yellow sac spiders (genus Cheiracanthium) in the United States and Australia: Where is the necrosis? Am J Trop Med Hyg. 2006;74(6):1043–8.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
T. Varl, D. Grenc, R. Kostanjšek, and M. Brvar declare that they have no competing interests.
Rights and permissions
About this article
Cite this article
Varl, T., Grenc, D., Kostanjšek, R. et al. Yellow sac spider (Cheiracanthium punctorium) bites in Slovenia: case series and review. Wien Klin Wochenschr 129, 630–633 (2017). https://doi.org/10.1007/s00508-017-1217-8
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00508-017-1217-8