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Xanthelasma palpebrarum associated with increased cardio-ankle vascular index in asymptomatic subjects

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Summary

Background

Xanthelasma palpebrarum (XP) is associated with increased risk of ischemic heart disease and myocardial infarction independent of other well-known cardiovascular risk factors. Cardio-ankle vascular index (CAVI) is a novel index of arterial stiffness and important marker of subclinical atherosclerosis. The purpose of this study was to investigate the association between XP and CAVI in asymptomatic subjects.

Methods

Consecutive 50 subjects with XP and age-gender matched 50 control subjects were enrolled. Patients with known atherosclerotic vascular disease were excluded. Arterial stiffness was assessed by CAVI and defined as abnormal if CAVI is ≥ 8.

Results

Subjects with XP had higher mean CAVI than control subjects (8.05 ± 1.72 vs. 6.76 ± 1.18, p < 0.001). Frequency of abnormal CAVI was higher in subjects with XP (n = 27) compared to those without XP (n = 9, 54 vs. 18 %, p < 0.001). There was a significant correlation between XP and CAVI (r = 0.42, p < 0.001). Conditional logistic regression analysis showed that XP (odds ratio OR 8.80, 95 % confidence interval CI 2.63–29.49, p < 0.001) and age (OR 1.17, 95 % CI 1.08–1.26, p < 0.001) were independent predictors for abnormal CAVI.

Conclusion

The study suggests that XP is associated with increased arterial stiffness in asymptomatic subjects.

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Authors and Affiliations

  1. Department of Cardiology, Ahi Evren Cardiovascular and Thoracic Surgery Training and Research Hospital, Trabzon, Turkey

    Ali Rıza Akyüz MD, Turhan Turan, Selim Kul, Levent Korkmaz & Şükrü Çelik

  2. Department of Cardiology, Osmaniye State Hospital, Osmaniye, Turkey

    İsmail Gürbak

  3. Department of Cardiology, Faculty of Medicine, Harran University, Şanlıurfa, Turkey

    Musluhittin Emre Erkuş

  4. Department of Cardiology, Faculty of Medicine, Sakarya University, Sakarya, Turkey

    Mustafa Tarık Ağaç

Authors
  1. Ali Rıza Akyüz MD
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  2. Turhan Turan
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  3. Musluhittin Emre Erkuş
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  5. Selim Kul
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  7. Mustafa Tarık Ağaç
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  8. Şükrü Çelik
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Correspondence to Ali Rıza Akyüz MD.

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Conflicts of interest

A. R. Akyüz, T. Turan, M. E. Erkuş, İ. Gürbak, S. Kul, L. Korkmaz, M. T. Ağaç, and Ş. Çelik declare that there are no actual or potential conflicts of interest in relation to this article.

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Akyüz, A.R., Turan, T., Erkuş, M.E. et al. Xanthelasma palpebrarum associated with increased cardio-ankle vascular index in asymptomatic subjects. Wien Klin Wochenschr 128 (Suppl 8), 610–613 (2016). https://doi.org/10.1007/s00508-016-0989-6

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  • DOI: https://doi.org/10.1007/s00508-016-0989-6

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