Wiener klinische Wochenschrift

, Volume 127, Issue 9–10, pp 385–387 | Cite as

The electronic cigarette: a wolf in sheep’s clothing

  • Manfred NeubergerEmail author
review article


The American Heart Association warned from the potential of electronic cigarettes to renormalize smoking in public and the International Respiratory Societies demanded regulation of all nicotine products as medicines or tobacco products. This review summarizes the results of studies on hazards of e-cigarette use, which has increased dramatically and may be the real threat for the achievements in tobacco control of the past 20 years.


Electronic cigarette Review Nicotine Aerosol 


  1. 1.
    Neuberger M. Recent recommendations endanger progress of tobacco control. (letter) Brit Med J. 2007;334:s16.CrossRefGoogle Scholar
  2. 2.
    Bunnel RE, Agaku IT, Arrazola RA, et al. Intentions to smoke cigarettes among never-smoking U.S. middle and high school electronic cigarette users, National Youth Tobacco Survey, 2011–2013. Nicotine Tob Res. 2014; doi:10.1093/ntr/ntu166. Epub ahead of print.Google Scholar
  3. 3.
  4. 4.
    Bjartveit K, Tverdal A. Health consequences of smoking 1–4 cigarettes per day. Tob Control. 2005;14(5):315–20.CrossRefPubMedCentralPubMedGoogle Scholar
  5. 5.
    Ginzel KH, Maritz GS, Marks DF, et al. Critical review: nicotine for the fetus, the infant and the adolescent? J Health Psychol. 2007;12(2):215–24.CrossRefPubMedGoogle Scholar
  6. 6.
    Grando SA. Connections of nicotine to cancer. Nat Rev Cancer. 2014;14(6):419–29.CrossRefPubMedGoogle Scholar
  7. 7.
    Bavarva JH, Tae H, McIver L, Garner HR. Nicotine and oxidative stress induced exomic variations are concordant and overrepresented in cancer-associated genes. Oncotarget. 2014;5:4788–98.PubMedCentralPubMedGoogle Scholar
  8. 8.
    Hutzler C, Paschke M, Kruschinski S, Henkler F, Hahn J, Luch A. Chemical hazards present in liquids and vapors of electronic cigarettes. Arch Toxicol. 2014;88(7):1295–308.CrossRefPubMedGoogle Scholar
  9. 9.
    Flouris AD, Chorti MS, Poulianiti KP, et al. Acute impact of active and passive electronic cigarette smoking on serum cotinine and lung function. Inhal Toxicol. 2013;25(2):91–101.CrossRefPubMedGoogle Scholar
  10. 10.
    Ballbè M, Martínez-Sánchez JM, Sureda X, et al. Cigarettes vs. e-cigarettes: passive exposure at home measured by means of airborne marker and biomarkers. Environ Res. 2014;135:76–80.CrossRefPubMedGoogle Scholar
  11. 11.
    Cobb NK, Abrams DB. The FDA, e-cigarettes, and the demise of combusted tobacco. N Engl J Med. 2014;371(16):1469–71.CrossRefPubMedGoogle Scholar
  12. 12.
    Goniewicz ML, Knysak J, Gawron M, et al. Levels of selected carcinogens and toxicants in vapour from electronic cigarettes. Tob Control. 2014;23:133–9.CrossRefPubMedGoogle Scholar
  13. 13.
    Trassierraa CV, Cardellini F, Buonannoa G, De Felice P. On the interaction between radon progeny and particles generated by electronic and traditional cigarettes. Atmos Environ. 2014. Epub ahead of print.Google Scholar
  14. 14.
    Park SJ, Walser TC, Perdomo C, et al. The effect of e-cigarette exposure on airway epithelial cell gene expression and transformation. Clin Cancer Res. 2014;20:B16CrossRefGoogle Scholar
  15. 15.
    Ingebrethsen BJ, Cole SK, Alderman SL. Electronic cigarette aerosol particle size distribution measurements. Inhal Toxicol. 2012;24:976–84.CrossRefPubMedGoogle Scholar
  16. 16.
    Fuoco FC, Buonanno G, Stabile L, Vigo P. Influential parameters on particle concentration and size distribution in the mainstream of e-cigarettes. Environ Pollut. 2014;184:523–9.CrossRefPubMedGoogle Scholar
  17. 17.
    Schripp T, Markewitz D, Uhde E, Salthammer T. Does e-cigarette consumption cause passive vaping? Indoor Air. 2013;23(1):25–31.CrossRefPubMedGoogle Scholar
  18. 18.
    Schober W, Szendrei K, Matzen W, et al. Use of electronic cigarettes impairs indoor air quality and increases FeNO levels of e-cigarette consumers. Int J Hyg Environ Health. 2014;217:628–37.CrossRefPubMedGoogle Scholar
  19. 19.
    Ruprecht AA, De Marco C, Pozzi P, et al. Comparison between particulate matter and ultrafine particle emission by electronic and normal cigarettes in real-life conditions. Tumori. 2014;100(1):e24–7. doi:10.1700/1430.15833.PubMedGoogle Scholar
  20. 20.
    Neuberger M. Feinstaub und akutes Koronarsyndrom. Univers Inn Med. 2008;01:47–9.Google Scholar
  21. 21.
    Farsalinos KE, Polosa R. Safety evaluation and risk assessment of electronic cigarettes as tobacco cigarette substitutes: a systematic review. Ther Adv Drug Saf. 2014;5(2):67–86.CrossRefPubMedCentralPubMedGoogle Scholar
  22. 22.
    Hadwiger ME, Trehy ML, Ye W, Moore T, Allgire J, Westenberger B. Identification of amino-tadalafil and rimonabant in electronic cigarette products using high pressure liquid chromatography with diode array and tandem mass spectrometric detection. J Chromatogr A. 2010;1217:7547–55.CrossRefPubMedGoogle Scholar
  23. 23.
    Vardavas CI, Anagnostopoulos N, Kougias M, Evangelopoulou V, Connolly GN, Behrakis PK. Short-term pulmonary effects of using an electronic cigarette: impact on respiratory flow resistance, impedance, and exhaled nitric oxide.Google Scholar
  24. 24.
    Marini S, Buonanno G, Stabile L, Ficco G. Short-term effects of electronic and tobacco cigarettes on exhaled nitric oxide. Toxicol Appl Pharmacol. 2014;278(1):9–15.CrossRefPubMedGoogle Scholar
  25. 25.
    McCauley L, Markin C, Hosmer D. An unexpected consequence of electronic cigarette use. Chest. 2012;141(4):1110–3.CrossRefPubMedGoogle Scholar
  26. 26.
    Moline JM, Golden AL, Highland JH, Wilmarth KR, Kao AS. Health Effects, Evaluation of Theatrical Smoke, Haze and Pyrotechnics. Report. Equity-League Pension and Health Trust Funds, 2000.Google Scholar
  27. 27.
    Bhatnagar A, Whitsel LP, Ribisl KM, et al. Electronic cigarettes. A policy statement from the American Heart Association. Circulation. 2014;130:1418–36.CrossRefPubMedGoogle Scholar
  28. 28.
    Schraufnagel DE, Blasi F, Drummond MB, et al. Electronic cigarettes. A position statement of the forum of international respiratory societies. Am J Respir Crit Care Med. 2014;190(6):611–8.CrossRefPubMedGoogle Scholar
  29. 29.
  30. 30.
  31. 31.

Copyright information

© Springer-Verlag Wien 2015

Authors and Affiliations

  1. 1.o. Univ.-Prof.em., Medical University of ViennaViennaAustria

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