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Is iron-deficiency anemia associated with migraine? Is there a role for anxiety and depression?

Summary

Background

In this study, we determined the frequency of migraine headache in iron-deficiency anemia (IDA) patients and whether it was related to anxiety, depression, and somatization.

Methods

We included 127 consecutive IDA patients into the study. All patients were asked validated questions about headache and migraine face-to-face. They were administered validated questionnaires for anxiety-depression The Hospital Anxiety and Depression Scale and somatization. The quality of life (QoL) disturbance associated with headache was marked on a 0–10 VAS.

Results

Of all IDA patients, 79.5 % defined headache at any time of their life. In addition, 36.2 % of all IDA patients defined the criteria for migraine. IDA patients with migraine were more frequently smokers and had significantly lower hemoglobin and mean corpuscular volume values (p values < 0.05). The IDA group with migraine had significantly higher mean anxiety score (p = 0.046) and headache-related QoL disturbance score (p = 0.021) than the IDA group without migraine. Migraine patients with aura had lower hemoglobin values (p = 0.02), higher depression scores (p = 0.005), and higher migraine-related QoL disturbance scores than others.

Conclusions

IDA patients have a high frequency of migraine headache. The presence of anxiety and depression have great influence on the presence of migraine in IDA patients.

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References

  1. Beard JL, Connor JR. Iron status and neural functioning. In: McCormick DB, Bier DM, Cousin RJ, editors. Annual review of nutrition. Vol. 23. Palo Alto: Annual Reviews; 2003. pp. 41–58.

    Google Scholar 

  2. Connor JR, Menzies SL. Relationship of iron to oligodendrocytes and myelination. Glia. 1996;17:83–93.

    CAS  Article  PubMed  Google Scholar 

  3. Takeda A. Significance of transferin in iron delivery to the brain. J Health Sci. 2001;47:520–4.

    CAS  Article  Google Scholar 

  4. Lozoff B, Jimenez E, Hagen J, Mollen E, Wolf AW. Poorer behavioral and developmental outcome more than 10 years after treatment for iron deficiency in infancy. Pediatrics. 2000;105:E51.

    CAS  Article  PubMed  Google Scholar 

  5. Shariatpanaahi MV, Shariatpanaahi ZV, Moshtaaghi M, Shahbaazi SH, Abadi A. The relationship between depression and serum ferritin level. Eur J Clin Nutr. 2007;61:532–5.

    Google Scholar 

  6. Hagen K, Stovner LJ, Asberg A, Thorstensen K, Bjerve KS, Hveem K. High headache prevalence among women with hemochomatosis: the NordTrondelag health study. Ann Neurol. 2002;51:786–9.

    Article  PubMed  Google Scholar 

  7. Celik Y, Ekuklu G, Tokuc B, Utku U. Migraine prevalence and some related factors in Turkey. Headache. 2005;45:32–6.

    Article  PubMed  Google Scholar 

  8. Pamuk GE, Pamuk ON, Set T, Harmandar O, Yeşil N. An increased prevalence of fibromyalgia in iron deficiency anemia and thalassemia minor and associated factors. Clin Rheumatol. 2008;27:1103–8.

    Article  PubMed  Google Scholar 

  9. Aydemir O. Validity and reliability of Turkish version of hospital anxiety and depression scale. Turk Psikiyatr Derg. 1997;8:280–7.

    Google Scholar 

  10. Classification and diagnostic criteria for headache disorders, cranial neuralgia, and facial pain. Cephalalgia. 1988;8(Suppl. 7):1–96.

  11. Zigmond AS, Snaith RP. The hospital anxiety and depression scale. Acta Psychiatr Scand. 1983;67:361–70.

    CAS  Article  PubMed  Google Scholar 

  12. Kececi H, Dener S. Epidemiological and clinical characteristics of migraine in Sivas, Turkey. Headache. 2002;42:275–80.

    Article  PubMed  Google Scholar 

  13. Henry P, Auray JP, Gaudin AF, Dartigues JF, Duru G, Lantéri-Minet M, Lucas C, Pradalier A, Chazot G, El Hasnaoui A. Prevalence and clinical characteristics of migraine in France. Neurology. 2002;59:232–7.

    CAS  Article  PubMed  Google Scholar 

  14. Dahlof C, Linde M. One-year prevalence of migraine in Sweden: a population-based study in adults. Cephalalgia. 2001;21:664–71.

    CAS  Article  PubMed  Google Scholar 

  15. Sunghthong R, Mo-suwan L, Chongsuvivatwong V. Effects of haemoglobin and serum ferritin on cognitive function in school children. Asia Pac J Clin Nutr. 1996;11:117–22.

    Article  Google Scholar 

  16. Bruner AB, Joffe A, Duggan AK, Casella JF, Brandt J. Randomised study of cognitive effects of iron supplementation in nonanaemic iron deficient adolescent girls. Lancet. 1996;348:992–6.

    CAS  Article  PubMed  Google Scholar 

  17. Rangan AM, Blight GD, Binns CW. Iron status and non-specific symptoms of female students. J Am Coll Nutr. 1998;17:351–5.

    CAS  Article  PubMed  Google Scholar 

  18. Gupta R, Lahan V, Goel D. Primary headaches in restless legs syndrome patients. Ann Indian Acad Neurol. 2012;15(Suppl. 1):104–8.

    Article  Google Scholar 

  19. Yücel M, Akgün H, Oz O, Demirkaya S. Migraine and restless leg syndrome co-morbidity may be due to iron deficiency. Ann Indian Acad Neurol. 2013;16:461.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Vukovic-Cvetkovic V, Plavec D, Lovrencic-Huzjan A, Galinovic I, Seric V, Demarin V. Is iron deficiency anemia related to menstrual migraine? Post hoc analysis of an observational study evaluating clinical characteristics of patients with menstrual migraine. Acta Clin Croat. 2010;49:389–94.

    PubMed  Google Scholar 

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Correspondence to Gülsüm Emel Pamuk MD.

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Pamuk, G., Top, M., Uyanık, M. et al. Is iron-deficiency anemia associated with migraine? Is there a role for anxiety and depression?. Wien Klin Wochenschr 128, 576–580 (2016). https://doi.org/10.1007/s00508-015-0740-8

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  • DOI: https://doi.org/10.1007/s00508-015-0740-8

Keywords

  • Iron-deficiency anemia
  • Migraine
  • Headache
  • Anxiety
  • Depression