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Association between coffee consumption and an oxidative stress marker in women

Zusammenhang zwischen Kaffeekonsum und Markern des oxydativen Stresses bei Frauen

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Coffee is one of the major dietary modulators of oxidative stress conditions. Whether coffee consumption is associated with oxidative stress markers, such as derivatives of reactive oxygen metabolites (d-ROMs), remains to be investigated in women, despite one recent report describing their significant association in men.


A total of 415 women (49 ± 9 years) attending a general clinic were evaluated regarding their self-reported coffee consumption habits and blood d-ROMs levels.


Women who reported ≥ 3 cups/day of coffee consumption displayed a lower d-ROMs level than those who reported consuming 0–2 cups/day (336 ± 67 vs. 358 ± 80 Carr U; p < 0.05). In the multivariate-adjusted analysis, the association between coffee consumption and the d-ROMs level remained to be significant (p < 0.05).


Daily coffee consumption (i.e., ≥ 3 cups) may be associated with a reduced oxidative stress status, as measured by the d-ROMs level, among women.



Kaffee ist einer der wichtigsten Diät-Modulatoren des oxydativen Stresses. Ob der Genuss von Kaffee mit Markern des oxydativen Stresses, wie Derivaten der reaktiven Sauerstoff Metaboliten (d-ROMs), zusammenhängt, ist bei Frauen noch nicht untersucht worden. Bei Männern ist kürzlich eine signifikante Beziehung beschrieben worden.


Bei insgesamt 415 Frauen (Alter: 49 ± 9 Jahre), die eine allgemeinmedizinische Klinik aufsuchten, wurden ihre selbst berichteten Kaffeekonsum-Gewohnheiten und ihre Blut d-ROMs Werte erhoben.


Frauen, die laut eigener Angabe mehr als 3 Tassen Kaffee pro Tag konsumierten, hatten niedrigere d-ROMs Spiegel als jene, die 0–2 Tassen Kaffee pro Tag angaben (336 ± 67 vs. 358 ± 80 Carr U; p < 0,05). In der Multivarianzanalyse blieb die Beziehung zwischen Kaffeekonsum und den d-ROMs Werten signifikant (p < 0,05).


Ein täglicher Kaffeekonsum von mehr als drei Tassen pro Tag scheint bei Frauen mit einem verminderten oxydativen Stress Status (beurteilt an Hand der d-ROMs Werte) einherzugehen.

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  1. Butt MS, Sultan MT. Coffee and its consumption: benefits and risks. Crit Rev Food Sci Nutr. 2011;51:363–73.

    Article  CAS  PubMed  Google Scholar 

  2. Scalbert A, Williamson G. Dietary intake and bioavailability of polyphenols. J Nutr. 2000;130:2073–85.

    Google Scholar 

  3. Olthof MR, Hollman PC, Katan MB. Chlorogenic acid and caffeic acid are absorbed in humans. J Nutr. 2001;131:66–71.

    CAS  PubMed  Google Scholar 

  4. Yukawa GS, Mune M, Otani H, Tone Y, Liang XM, Iwahashi H, Sakamoto W. Effects of coffee consumption on oxidative susceptibility of low-density lipoproteins and serum lipid levels in humans. Biochemistry. 2004;69:70–4.

    CAS  PubMed  Google Scholar 

  5. Trotti R, Carratelli M, Barbieri M, Micieli G, Bosone D, Rondanelli M, Bo P. Oxidative stress and a thrombophilic condition in alcoholics without severe liver disease. Haematologica. 2001;86:85–91.

    CAS  PubMed  Google Scholar 

  6. Chen JT, Kotani K. Oral contraceptive therapy increases oxidative stress in pre-menopausal women. Int J Prev Med. 2012;3(12):893–6.

    Article  PubMed Central  PubMed  Google Scholar 

  7. Ishizaka Y, Yamakado M, Toda A, Tani M, Ishizaka N. Relationship between coffee consumption, oxidant status, and antioxidant potential in the Japanese general population. Clin Chem Lab Med. 2013;51:1951–9.

    Article  CAS  PubMed  Google Scholar 

  8. van Woudenbergh GJ, Vliegenthart R, van Rooij FJ, Hofman A, Oudkerk M, Witteman JC, Geleijnse JM. Coffee consumption and coronary calcification: the Rotterdam Coronary Calcification Study. Arterioscler Thromb Vasc Biol. 2008;28:1018–23.

    Article  PubMed  Google Scholar 

  9. Sugiyama K, Kuriyama S, Akhter M, Kakizaki M, Nakaya N, Ohmori-Matsuda K, Shimazu T, Nagai M, Sugawara Y, Hozawa A, Fukao A, Tsuji I. Coffee consumption and mortality due to all causes, cardiovascular disease, and cancer in Japanese women. J Nutr. 2010;140:1007–13.

    Article  CAS  PubMed  Google Scholar 

  10. Arab L, Biggs ML, O’Meara ES, Longstreth WT, Crane PK, Fitzpatrick AL. Gender differences in tea, coffee, and cognitive decline in the elderly: the Cardiovascular Health Study. J Alzheimers Dis. 2011;27:553–66.

    CAS  PubMed Central  PubMed  Google Scholar 

  11. Teramoto T, Sasaki J, Ishibashi S, Birou S, Daida H, Dohi S, Egusa G, Hiro T, Hirobe K, Iida M, Kihara S, Kinoshita M, Maruyama C, Ohta T, Okamura T, Yamashita S, Yokode M, Yokote K; Japan Atherosclerosis Society (JAS). Comprehensive risk management for the prevention of cardiovascular disease: executive summary of the Japan Atherosclerosis Society (JAS) guidelines for the diagnosis and prevention of atherosclerotic cardiovascular diseases in Japan—2012. J Atheroscler Thromb. 2013;20:603–15.

    Article  PubMed  Google Scholar 

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Correspondence to Jui-Tung Chen MD, PhD.

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Chen, JT., Kotani, K. Association between coffee consumption and an oxidative stress marker in women. Wien Klin Wochenschr 127, 567–569 (2015).

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