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Imaging of gastrinomas by nuclear medicine methods

Lokalisation von Gastrinomen mit nuklearmedizinischen Methoden

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Zusammenfassung

Die Somatostatin Rezeptor Szintigraphie (SRS) kann zur Detektion von pathologischen Vorgängen mit einer erhöhten Rezeptorexpression verwendet werden. Die meisten Gastrinome (über-) exprimieren Somatostatin Rezeptoren des Subtyps 2, an welche das auf Octreotid basierenden radioaktiv markierten OctreoScan-111 bindet. Verschiedene Studien zeigen eine hohe Sensitivität der SRS im Bezug auf die Lokalisation und das Staging von Gastrinomen. In dieser Hinsicht scheint die SRS den anderen nicht invasiven Bildgebungsmodalitäten überlegen zu sein. Die Sensitivität hängt aber entscheidend von der Größe und der Lokalisation der Läsion ab. Kleinere Läsionen und Läsionen im Duodenum zeigen eine signifikant niedrigere Sensitivität. Trotzdem kann man zusammenfassend sagen, dass die SRS zu den Routinebildgebungsmethoden zur Lokalisation und zum Staging von Gastrinomen zählt und zur Progressionsbeurteilung des Tumors eingesetzt wird.

Summary

Somatostatin receptor scintigraphy (SRS) is a valuable method for the detection of somatostain receptor-positive lesions. Most gastrinomas (over-)express the somatostatin receptor subtype 2 which can be targeted by In-111 labeled Octreotide®. Different studies show a high sensitivity of SRS for the localization and staging of gastrinomas. SRS seems to be superior to other non-invasive imaging modalities and has been proven to significantly contribute to patient management. However, the sensitivity depends on the size and exact localization of the tumors. Smaller lesions and lesions located in the duodenum show a significantly lower sensitivity. In any case, SRS belongs to the routine imaging procedure for gastrinomas for localization and staging and can also be used for evaluation of the tumor progression.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Philipps-University of Marburg, Marburg, Germany

    Martin Béhé & Thomas M. Behr

  2. Department of Nuclear Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands

    Martin Gotthardt

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  1. Martin Béhé
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  2. Martin Gotthardt
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  3. Thomas M. Behr
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Correspondence to Martin Béhé.

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Béhé, M., Gotthardt, M. & Behr, T. Imaging of gastrinomas by nuclear medicine methods. Wien Klin Wochenschr 119, 593–596 (2007). https://doi.org/10.1007/s00508-007-0881-5

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  • DOI: https://doi.org/10.1007/s00508-007-0881-5

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