Zusammenfassung
Die korrekte Lokalisation pankreatischer Gastrinome mittels Endosonographie ist in den meisten Fällen zuverlässig möglich, während die Erfolgsrate bei Gastrinomen in der Duodenalwand enttäuschend ist, selbst wenn die Untersuchung unter idealen Bedingungen durch einen erfahrenen Untersucher durchgeführt wird. Dennoch ist die endosonographische Diagnostik bedeutsam, da sich in speziellen Situationen wichtige Informationen liefern kann. Neben dem Nachweis des Primärtumors können andere relevante Strukturen identifiziert werden, bspw. Metastasen-suspekte Befunde im Bereich des Gastrinom-Dreiecks.
Summary
Correct localisation of pancreatic gastrinomas by endoscopic ultrasound seems to be possible in most cases. However, success rate in the duodenal wall is disappointing, even if the examination is performed under optimal circumstances by a very experienced examiner. Nevertheless, in certain conditions endoscopic ultrasound may yield important information, besides detection of the primary tumor for example about structures suspected to be metastases in the region of the gastrinoma triangle.
References
Campana D, Piscitelli L, Mazzotta E, Bonora M, Serra C, Salomone L, Corinaldesi R, Tomassetti P (2005) Zollinger-Ellison syndrome. Diagnosis and therapy. Minerva Med 96: 187–206
Kann P, Bittinger F, Engelbach M, Bohner S, Weis A, Beyer J (2001) Endosonography of insulin-secreting and clinically non-functioning neuroendocrine tumors of the pancreas: criteria for benignancy and malignancy. Eur J Med Res 6: 385–390
Kann PH, Wirkus B, Keth A, Goitom K (2003) Pitfalls in endosonographic imaging of suspected insulinomas: pancreatic nodules of unknown dignity. Eur J Endocrinol 148: 531–534
Kann PH, Rothmund M, Zielke A (2005) Endoscopic ultrasound imaging of insulinomas: limitations and clinical relevance. Exp Clin Endocrinol Diabetes 113: 471–474
Langer P, Kann PH, Fendrich V, Richter G, Diehl S, Rothmund M, Bartsch DK (2004) Prospective evaluation of imaging procedures for the detection of pancreaticoduodenal endocrine tumors in patients with multiple endocrine neoplasia type 1. World J Surg 28: 1317–1322
Langer P, Bartsch DK, Fendrich V, Kann PH, Rothmund M, Zielke A (2005) Minimal-invasive operative treatment of organic hyperinsulinism. Dtsch Med Wochenschr 130: 514–518
Anderson MA, Carpenter S, Thompson NW, Nostrant TT, Elta GH, Scheiman JM (2000) Endoscopic ultrasound is highly accurate and directs management in patients with neuroendocrine tumors of the pancreas. Am J Gastroenterol 95: 2271–2277
Mirallie E, Pattou F, Malvaux P, Filoche B, Godchaux JM, Maunoury V, Palazzo L, Lefebvre J, Huglo D, Paris JC, Carnaille B, Proye C (2002) Value of endoscopic ultrasonography and somatostatin receptor scintigraphy in the preoperative localization of insulinomas and gastrinomas. Experience of 54 cases. Gastroenterol Clin Biol 26: 360–366
Proye C, Malvaux P, Pattou F, Filoche B, Godchaux JM, Maunoury V, Palazzo L, Huglo D, Lefebvre J, Paris JC (1998) Noninvasive imaging of insulinomas and gastrinomas with endoscopic ultrasonography and somatostatin receptor scintigraphy. Surgery 124: 1134–1143
Ruszniewski P, Amouyal P, Amouyal G, Grange JD, Mignon M, Bouche O, Bernades P (1995) Localization of gastrinomas by endoscopic ultrasonography in patients with Zollinger-Ellison syndrome. Surgery 117: 629–635
Power N, Reznek RH (2002) Imaging of pancreatic islet cell tumours. Imaging 14: 147–159
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Kann, P. The value of endoscopic ultrasound in localizing gastrinoma. Wien Klin Wochenschr 119, 585–587 (2007). https://doi.org/10.1007/s00508-007-0880-6
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DOI: https://doi.org/10.1007/s00508-007-0880-6