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Diagnosis and treatment of gastric neuroendocrine tumours

Diagnose und Therapie gastro-intestinaler neuroendokriner Magentumore

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Zusammenfassung

Neuroendokrine Tumore (NET) des Magens sind selten. Klinisch werden sie in Typ 1 bis 3 unterteilt. Histologisch werden diese Tumoren nach der WHO 2000 klassifiziert. NET Typ-1 können im Rahmen einer chronisch atrophen Gastritis als einzelne oder multiple, kleine Tumoren auftreten. Die Prognose dieser Tumoren ist sehr gut. Diese Tumoren als Todesursache werden nicht beschrieben. NET Typ-2 werden im Rahmen des MEN1-Syndroms beobachtet. Diese Tumoren sind aggressiver und können Metastasen setzen. Meistens ist aber die Todesursache bei MEN-1-Syndroms ein neuroendokriner Tumor des Duodenums oder Magens. NET Typ-3 treten sporadisch ohne zusätzliche Magenpathologie auf. Diese Tumoren treten früh ohne Geschlechtsbevorzugung auf. Bei aggressivem Verlauf setzen sie Metastasen und haben insgesamt eine schlechte Prognose. Ein aggressive chirurgische Therapie ist zu empfehlen.

Summary

Gastric neuroendocrine tumours (NET) are rare. Clinically they are classified in tumours type 1 to 3. The histological classification is according to the WHO 2000 classification for endocrine tumours. NET type 1 occur in coincidence with chronic atrophic gastritis, as single or multiple small tumours. The prognosis of type 1 tumours is excellent, with no tumour related death reported during follow-up. NET type 2 are part of the MEN-1 syndrome. These tumours may be more aggressive and even develop metastasis. However, in most patients with MEN-1 the prognosis is due to other manifestations of the disease as duodenal or pancreatic neuroendocrine tumours. Gastric neuroendocrine tumours type 3 are sporadic tumours without relationship to other gastric pathology. They tend to occur earlier, without sex preference. These tumours may develop an aggressive course, with metastatic disease and an overall poor prognosis. Thus, aggressive surgical therapy is recommended.

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References

  • Plockinger U, Rindi G, Arnold R, Eriksson B, Krenning EP, de Herder WW, et al (2004) Guidelines for the diagnosis and treatment of neuroendocrine gastrointestinal tumours. A consensus statement on behalf of the European Neuroendocrine Tumour Society (ENETS). Neuroendocrinology 80: 394–424

    Article  PubMed  CAS  Google Scholar 

  • Rindi G, Capella C, Solcia E (2000) Introduction to a revised clinicopathological classification of neuroendocrine tumors of the gastroenteropancreatic tract. Q J Nucl Med 44: 13–21

    PubMed  CAS  Google Scholar 

  • Solcia E, Rindi G, Larosa S, Capella C (2000) Morphological, molecular, and prognostic aspects of gastric endocrine tumors. Microsc Res Tech 48: 339–348

    Article  PubMed  CAS  Google Scholar 

  • Solcia E, Rindi G, Buffa R, Fiocca R, Capella C (2000) Gastric endocrine cells: types, function and growth. Regul Pept 93: 31–35

    Article  PubMed  CAS  Google Scholar 

  • Rindi G, Kloppel G (2004) Endocrine tumors of the gut and pancreas tumor biology and classification. Neuroendocrinology 80 [Suppl 1]: 12–15

    Article  PubMed  CAS  Google Scholar 

  • Kloppel G, Perren A, Heitz PU (2004) The gastroenteropancreatic neuroendocrine cell system and its tumors: the WHO classification. Ann NY Acad Sci 1014: 13–27

    Article  PubMed  Google Scholar 

  • Rindi G, Paolotti D, Fiocca R, Wiedenmann B, Henry JP, Solcia E (2000) Vesicular monoamine transporter 2 as a marker of gastric enterochromaffin-like cell tumors. Virchows Arch 436: 217–223

    Article  PubMed  CAS  Google Scholar 

  • Borch K, Ahren B, Ahlman H, Falkmer S, Granerus G, Grimelius L (2005) Gastric carcinoids: biologic behavior and prognosis after differentiated treatment in relation to type. Ann Surg 242: 64–73

    Article  PubMed  Google Scholar 

  • Xie SD, Wang LB, Song XY, Pan T (2004) Minute gastric carcinoid tumor with regional lymph node metastasis: a case report and review of literature. World J Gastroenterol 10: 2461–2463

    PubMed  Google Scholar 

  • Fykse V, Sandvik AK, Qvigstad G, Falkmer SE, Syversen U, Waldum HL (2004) Treatment of ECL cell carcinoids with octreotide LAR. Scand J Gastroenterol 39: 621–628

    Article  PubMed  CAS  Google Scholar 

  • Delle Fave G, Capurso G, Annibale B, Panzuto F (2004) Gastric neuroendocrine tumors. Neuroendocrinology 80 [Suppl 1]: 16–19

    Article  PubMed  CAS  Google Scholar 

  • Modlin IM, Kidd M, Latich I, Zikusoka MN, Shapiro MD (2005) Current status of gastrointestinal carcinoids. Gastroenterology 128: 1717–1751

    Article  PubMed  Google Scholar 

  • Norton JA, Melcher ML, Gibril F, Jensen RT (2004) Gastric carcinoid tumors in multiple endocrine neoplasia-1 patients with Zollinger-Ellison syndrome can be symptomatic, demonstrate aggressive growth, and require surgical treatment. Surgery 136: 1267–1274

    Article  PubMed  Google Scholar 

  • Mulkeen A, Cha C (2005) Gastric carcinoid. Curr Opin Oncol 17: 1–6

    Article  PubMed  Google Scholar 

  • Thomas RM, Baybick JH, Elsayed AM, Sobin LH (1994) Gastric carcinoids. An immunohistochemical and clinicopathologic study of 104 patients. Cancer 73: 2053–2058

    Article  PubMed  CAS  Google Scholar 

  • Rindi G, Azzoni C, La Rosa S, Klersy C, Paolotti D, Rappel S, et al (1999) ECL cell tumor and poorly differentiated endocrine carcinoma of the stomach: prognostic evaluation by pathological analysis. Gastroenterology 116: 532–542

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Interdisziplinäres Stoffwechsel-Centrum: Endokrinologie, Diabetes und Stoffwechsel, Charité-Universitätsmedizin Berlin, Berlin, Germany

    Ursula Plöckinger

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  1. Ursula Plöckinger
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Correspondence to Ursula Plöckinger.

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Plöckinger, U. Diagnosis and treatment of gastric neuroendocrine tumours. Wien Klin Wochenschr 119, 570–572 (2007). https://doi.org/10.1007/s00508-007-0879-z

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  • DOI: https://doi.org/10.1007/s00508-007-0879-z

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