Skip to main content
Log in

Warum gibt es analoge Krankheitsmechanismen bei chronisch entzündlichen Krankheiten?

  • Sonderthema
  • Published:
Wiener klinische Wochenschrift Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Literatur

  • Agrawal B, Manickasundari M, Fraga E, Singh B (1991) T cells that recognize peptide sequences of self MHC class II molecules exist in syngeneic mice. J Immunol 147: 383–390

    PubMed  CAS  Google Scholar 

  • Angele MK, Ayala A, Monfils BA, Cioffi WG, Bland KI, Chaudry IH (1998) Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage. J Trauma 44: 78–85

    PubMed  CAS  Google Scholar 

  • Antonijevic IA (2006) Depressive disorders – is it time to endorse different pathophysiologies? Psychoneuroendocrinology 31: 1–15

    Article  PubMed  Google Scholar 

  • Besedovsky HO, Del Rey A (1996) Immune-neuro-endocrine interactions. Endocr Rev 17: 64–102

    Article  PubMed  CAS  Google Scholar 

  • Castagnetta LA, Carruba G, Granata OM, Stefano R, Miele M, Schmidt M, et al (2003) Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis. J Rheumatol 30: 2597–2605

    PubMed  CAS  Google Scholar 

  • Cid MC, Kleinman HK, Grant DS, Schnaper HW, Fauci AS, Hoffman GS (1994) Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1. J Clin Invest 93: 17–25

    Article  PubMed  CAS  Google Scholar 

  • Cutolo M, Wilder R (2000) Different roles for androgens and estrogens in the susceptibility to autoimmune rheumatic diseases. Rheum Dis Clin North Am 26: 825–839

    Article  PubMed  CAS  Google Scholar 

  • Ebringer A, Wilson C, Tiwana H (2000) Is rheumatoid arthritis a form of reactive arthritis? J Rheumatol 27: 559–563

    PubMed  CAS  Google Scholar 

  • Ehrhart-Bornstein M, Hinson JP, Bornstein SR, Scherbaum WA, Vinson GP (1998) Intraadrenal interactions in the regulation of adrenocortical steroidogenesis. Endocr Rev 19: 101–143

    Article  PubMed  CAS  Google Scholar 

  • Elenkov IJ, Iezzoni DG, Daly A, Harris AG, Chrousos GP (2005) Cytokine dysregulation, inflammation and well-being. Neuroimmunomodulation 12: 255–269

    Article  PubMed  CAS  Google Scholar 

  • Härle P, Straub RH, Wiest R, Maier A, Schölmerich J, Atzeni F, et al (2005) Increase of sympathetic outflow measured by NPY and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with SLE and RA – Another example of uncoupling of response systems. Ann Rheum Dis 65: 51–56

    Article  PubMed  CAS  Google Scholar 

  • Hecker-Kia A, Kolkenbrock H, Orgel D, Zimmermann B, Sparmann M, Ulbrich N (1997) Substance P induces the secretion of gelatinase A from human synovial fibroblasts. Eur J Clin Chem Clin Biochem 35: 655–660

    PubMed  CAS  Google Scholar 

  • Hermanson A, Dalsgaard CJ, Bjorklund H, Lindblom U (1987) Sensory reinnervation and sensibility after superficial skin wounds in human patients. Neurosci Lett 74: 377–382

    Article  PubMed  CAS  Google Scholar 

  • Janeway CA, Travers P, Walport M, Shlomchik M (2001) Immunobiology. Garland Publishing, New York

    Google Scholar 

  • Katayama I, Nishioka K (1997) Substance P augments fibrogenic cytokine-induced fibroblast proliferation: possible involvement of neuropeptide in tissue fibrosis. J Dermatol Sci 15: 201–206

    Article  PubMed  CAS  Google Scholar 

  • Konsman JP, Parnet P, Dantzer R (2002) Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci 25: 154–159

    Article  PubMed  CAS  Google Scholar 

  • Lephart ED, Baxter CR, Parker CR Jr (1987) Effect of burn trauma on adrenal and testicular steroid hormone production. J Clin Endocrinol Metab 64: 842–848

    Article  PubMed  CAS  Google Scholar 

  • Miller LE, Jüsten HP, Schölmerich J, Straub RH (2000) The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages. FASEB J 14: 2097–2107

    Article  PubMed  CAS  Google Scholar 

  • Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al (2004) Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 50: 380–386

    Article  PubMed  Google Scholar 

  • Parker CR Jr, Baxter CR (1985) Divergence in adrenal steroid secretory pattern after thermal injury in adult patients. J Trauma 25: 508–510

    Article  PubMed  Google Scholar 

  • Rantapää-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al (2003) Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 48: 2741–2749

    Article  PubMed  CAS  Google Scholar 

  • Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, et al (2001) Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 58: 445–452

    Article  PubMed  CAS  Google Scholar 

  • Reynolds ML, Fitzgerald M (1995) Long-term sensory hyperinnervation following neonatal skin wounds. J Comp Neurol 358: 487–498

    Article  PubMed  CAS  Google Scholar 

  • Salzer U, Chapel HM, Webster AD, Pan-Hammarstrom Q, Schmitt-Graeff A, Schlesier M, et al (2005) Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet 37: 820–828

    Article  PubMed  CAS  Google Scholar 

  • Schaible HG, Del Rosso A, Matucci-Cerinic M (2005) Neurogenic aspects of inflammation. Rheum Dis Clin North Am 31: 77–101

    Article  PubMed  Google Scholar 

  • Schmidt M, Weidler C, Naumann H, Schölmerich J, Straub RH (2005) Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens. Arthritis Research & Therapy 7: R938–R948

    Article  CAS  Google Scholar 

  • Schuld A, Mullington J, Friess E, Hermann DM, Galanos C, Holsboer F, et al (2000) Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers. J Clin Endocrinol Metab 85: 4624–4629

    Article  PubMed  CAS  Google Scholar 

  • Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, et al (1996) Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab 81: 3112–3118

    Article  PubMed  CAS  Google Scholar 

  • Shiokawa S, Yoshimura Y, Nagamatsu S, Sawa H, Hanashi H, Oda T, et al (1996) Expression of beta 1 integrins in human endometrial stromal and decidual cells. J Clin Endocrinol Metab 81: 1533–1540

    Article  PubMed  CAS  Google Scholar 

  • Straub RH, Besedovsky HO (2003) Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases. FASEB J 17: 2176–2183

    Article  PubMed  CAS  Google Scholar 

  • Straub RH, Cutolo M (2001) Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role. Arthritis Rheum 44: 493–507

    Article  PubMed  CAS  Google Scholar 

  • Straub RH, Cutolo M, Zietz B, Schölmerich J (2001) The process of aging changes the interplay of the immune, endocrine and nervous systems. Mech Ageing Dev 122: 1591–1611

    Article  PubMed  CAS  Google Scholar 

  • Straub RH, Herfarth H, Falk W, Andus T, Schölmerich J (2002) Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in inflammatory bowel disease? J Neuroimmunol 126: 116–125

    Article  PubMed  CAS  Google Scholar 

  • Straub RH, Paimela L, Peltomaa R, Schölmerich J, Leirisalo-Repo M (2002) Inadequately low serum levels of steroid hormones in relation to IL-6 and TNF in untreated patients with early rheumatoid arthritis and reactive arthritis. Arthritis Rheum 46: 654–662

    Article  PubMed  CAS  Google Scholar 

  • Straub RH, Schölmerich J, Zietz B (2000) Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases-substitutes of adrenal and sex hormones. Z Rheumatol 59 [Suppl 2]: II/108–II/118

    CAS  Google Scholar 

  • Straub RH, Schuld A, Mullington J, Haack M, Schölmerich J, Pollmächer T (2002) The endotoxin-induced increase of cytokines is followed by an increase of cortisol relative to dehydroepiandrosterone (DHEA) in healthy male subjects. J Endocrinol 175: 467–474

    Article  PubMed  CAS  Google Scholar 

  • Straub RH, Stebner K, Harle P, Kees F, Falk W, Scholmerich J (2005) Key role of the sympathetic microenvironment for the interplay of tumour necrosis factor and interleukin 6 in normal but not in inflamed mouse colon mucosa. Gut 54: 1098–1106

    Article  PubMed  CAS  Google Scholar 

  • Tonnesen MG, Feng X, Clark RA (2000) Angiogenesis in wound healing. J Investig Dermatol Symp Proc 5: 40–46

    Article  PubMed  CAS  Google Scholar 

  • Tsigos C, Papanicolaou DA, Kyrou I, Raptis SA, Chrousos GP (1999) Dose-dependent effects of recombinant human interleukin-6 on the pituitary-testicular axis. J Interferon Cytokine Res 19: 1271–1276

    Article  PubMed  CAS  Google Scholar 

  • Weidler C, Holzer C, Harbuz M, Hofbauer R, Angele P, Scholmerich J, et al (2005) Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium. Ann Rheum Dis 64: 13–20

    Article  PubMed  CAS  Google Scholar 

  • Weidler C, Schmidt M, Perlick L, Schölmerich J, Straub RH (2004) Placental growth factor is linked to inflammation, vascularization, and DHEAS to DHEA conversion in synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 50 [Suppl]: S157

    Google Scholar 

  • Yoshimura Y, Miyakoshi K, Hamatani T, Iwahashi K, Takahashi J, Kobayashi N, et al (1998) Role of beta 1 integrins in human endometrium and decidua during implantation. Horm Res 50 [Suppl] 2: 46–55

    Article  PubMed  CAS  Google Scholar 

  • Ziche M, Maglione D, Ribatti D, Morbidelli L, Lago CT, Battisti M, et al (1997) Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic. Lab Invest 76: 517–531

    PubMed  CAS  Google Scholar 

  • Ziche M, Morbidelli L, Pacini M, Dolara P, Maggi CA (1990) NK1-receptors mediate the proliferative response of human fibroblasts to tachykinins. Br J Pharmacol 100: 11–14

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Rainer H. Straub.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Straub, R., Besedovsky, H. & del Rey, A. Warum gibt es analoge Krankheitsmechanismen bei chronisch entzündlichen Krankheiten?. Wien Klin Wochenschr 119, 444–454 (2007). https://doi.org/10.1007/s00508-007-0834-z

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00508-007-0834-z

Navigation