Literatur
Agrawal B, Manickasundari M, Fraga E, Singh B (1991) T cells that recognize peptide sequences of self MHC class II molecules exist in syngeneic mice. J Immunol 147: 383–390
Angele MK, Ayala A, Monfils BA, Cioffi WG, Bland KI, Chaudry IH (1998) Testosterone and/or low estradiol: normally required but harmful immunologically for males after trauma-hemorrhage. J Trauma 44: 78–85
Antonijevic IA (2006) Depressive disorders – is it time to endorse different pathophysiologies? Psychoneuroendocrinology 31: 1–15
Besedovsky HO, Del Rey A (1996) Immune-neuro-endocrine interactions. Endocr Rev 17: 64–102
Castagnetta LA, Carruba G, Granata OM, Stefano R, Miele M, Schmidt M, et al (2003) Increased estrogen formation and estrogen to androgen ratio in the synovial fluid of patients with rheumatoid arthritis. J Rheumatol 30: 2597–2605
Cid MC, Kleinman HK, Grant DS, Schnaper HW, Fauci AS, Hoffman GS (1994) Estradiol enhances leukocyte binding to tumor necrosis factor (TNF)-stimulated endothelial cells via an increase in TNF-induced adhesion molecules E-selectin, intercellular adhesion molecule type 1, and vascular cell adhesion molecule type 1. J Clin Invest 93: 17–25
Cutolo M, Wilder R (2000) Different roles for androgens and estrogens in the susceptibility to autoimmune rheumatic diseases. Rheum Dis Clin North Am 26: 825–839
Ebringer A, Wilson C, Tiwana H (2000) Is rheumatoid arthritis a form of reactive arthritis? J Rheumatol 27: 559–563
Ehrhart-Bornstein M, Hinson JP, Bornstein SR, Scherbaum WA, Vinson GP (1998) Intraadrenal interactions in the regulation of adrenocortical steroidogenesis. Endocr Rev 19: 101–143
Elenkov IJ, Iezzoni DG, Daly A, Harris AG, Chrousos GP (2005) Cytokine dysregulation, inflammation and well-being. Neuroimmunomodulation 12: 255–269
Härle P, Straub RH, Wiest R, Maier A, Schölmerich J, Atzeni F, et al (2005) Increase of sympathetic outflow measured by NPY and decrease of the hypothalamic-pituitary-adrenal axis tone in patients with SLE and RA – Another example of uncoupling of response systems. Ann Rheum Dis 65: 51–56
Hecker-Kia A, Kolkenbrock H, Orgel D, Zimmermann B, Sparmann M, Ulbrich N (1997) Substance P induces the secretion of gelatinase A from human synovial fibroblasts. Eur J Clin Chem Clin Biochem 35: 655–660
Hermanson A, Dalsgaard CJ, Bjorklund H, Lindblom U (1987) Sensory reinnervation and sensibility after superficial skin wounds in human patients. Neurosci Lett 74: 377–382
Janeway CA, Travers P, Walport M, Shlomchik M (2001) Immunobiology. Garland Publishing, New York
Katayama I, Nishioka K (1997) Substance P augments fibrogenic cytokine-induced fibroblast proliferation: possible involvement of neuropeptide in tissue fibrosis. J Dermatol Sci 15: 201–206
Konsman JP, Parnet P, Dantzer R (2002) Cytokine-induced sickness behaviour: mechanisms and implications. Trends Neurosci 25: 154–159
Lephart ED, Baxter CR, Parker CR Jr (1987) Effect of burn trauma on adrenal and testicular steroid hormone production. J Clin Endocrinol Metab 64: 842–848
Miller LE, Jüsten HP, Schölmerich J, Straub RH (2000) The loss of sympathetic nerve fibers in the synovial tissue of patients with rheumatoid arthritis is accompanied by increased norepinephrine release from synovial macrophages. FASEB J 14: 2097–2107
Nielen MM, van Schaardenburg D, Reesink HW, van de Stadt RJ, van der Horst-Bruinsma IE, de Koning MH, et al (2004) Specific autoantibodies precede the symptoms of rheumatoid arthritis: a study of serial measurements in blood donors. Arthritis Rheum 50: 380–386
Parker CR Jr, Baxter CR (1985) Divergence in adrenal steroid secretory pattern after thermal injury in adult patients. J Trauma 25: 508–510
Rantapää-Dahlqvist S, de Jong BA, Berglin E, Hallmans G, Wadell G, Stenlund H, et al (2003) Antibodies against cyclic citrullinated peptide and IgA rheumatoid factor predict the development of rheumatoid arthritis. Arthritis Rheum 48: 2741–2749
Reichenberg A, Yirmiya R, Schuld A, Kraus T, Haack M, Morag A, et al (2001) Cytokine-associated emotional and cognitive disturbances in humans. Arch Gen Psychiatry 58: 445–452
Reynolds ML, Fitzgerald M (1995) Long-term sensory hyperinnervation following neonatal skin wounds. J Comp Neurol 358: 487–498
Salzer U, Chapel HM, Webster AD, Pan-Hammarstrom Q, Schmitt-Graeff A, Schlesier M, et al (2005) Mutations in TNFRSF13B encoding TACI are associated with common variable immunodeficiency in humans. Nat Genet 37: 820–828
Schaible HG, Del Rosso A, Matucci-Cerinic M (2005) Neurogenic aspects of inflammation. Rheum Dis Clin North Am 31: 77–101
Schmidt M, Weidler C, Naumann H, Schölmerich J, Straub RH (2005) Androgen conversion in osteoarthritis and rheumatoid arthritis synoviocytes – androstenedione and testosterone inhibit estrogen formation and favor production of more potent 5alpha-reduced androgens. Arthritis Research & Therapy 7: R938–R948
Schuld A, Mullington J, Friess E, Hermann DM, Galanos C, Holsboer F, et al (2000) Changes in dehydroepiandrosterone (DHEA) and DHEA-sulfate plasma levels during experimental endotoxinemia in healthy volunteers. J Clin Endocrinol Metab 85: 4624–4629
Shifren JL, Tseng JF, Zaloudek CJ, Ryan IP, Meng YG, Ferrara N, et al (1996) Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis. J Clin Endocrinol Metab 81: 3112–3118
Shiokawa S, Yoshimura Y, Nagamatsu S, Sawa H, Hanashi H, Oda T, et al (1996) Expression of beta 1 integrins in human endometrial stromal and decidual cells. J Clin Endocrinol Metab 81: 1533–1540
Straub RH, Besedovsky HO (2003) Integrated evolutionary, immunological, and neuroendocrine framework for the pathogenesis of chronic disabling inflammatory diseases. FASEB J 17: 2176–2183
Straub RH, Cutolo M (2001) Involvement of the hypothalamic-pituitary-adrenal/gonadal axis and the peripheral nervous system in rheumatoid arthritis: viewpoint based on a systemic pathogenetic role. Arthritis Rheum 44: 493–507
Straub RH, Cutolo M, Zietz B, Schölmerich J (2001) The process of aging changes the interplay of the immune, endocrine and nervous systems. Mech Ageing Dev 122: 1591–1611
Straub RH, Herfarth H, Falk W, Andus T, Schölmerich J (2002) Uncoupling of the sympathetic nervous system and the hypothalamic-pituitary-adrenal axis in inflammatory bowel disease? J Neuroimmunol 126: 116–125
Straub RH, Paimela L, Peltomaa R, Schölmerich J, Leirisalo-Repo M (2002) Inadequately low serum levels of steroid hormones in relation to IL-6 and TNF in untreated patients with early rheumatoid arthritis and reactive arthritis. Arthritis Rheum 46: 654–662
Straub RH, Schölmerich J, Zietz B (2000) Replacement therapy with DHEA plus corticosteroids in patients with chronic inflammatory diseases-substitutes of adrenal and sex hormones. Z Rheumatol 59 [Suppl 2]: II/108–II/118
Straub RH, Schuld A, Mullington J, Haack M, Schölmerich J, Pollmächer T (2002) The endotoxin-induced increase of cytokines is followed by an increase of cortisol relative to dehydroepiandrosterone (DHEA) in healthy male subjects. J Endocrinol 175: 467–474
Straub RH, Stebner K, Harle P, Kees F, Falk W, Scholmerich J (2005) Key role of the sympathetic microenvironment for the interplay of tumour necrosis factor and interleukin 6 in normal but not in inflamed mouse colon mucosa. Gut 54: 1098–1106
Tonnesen MG, Feng X, Clark RA (2000) Angiogenesis in wound healing. J Investig Dermatol Symp Proc 5: 40–46
Tsigos C, Papanicolaou DA, Kyrou I, Raptis SA, Chrousos GP (1999) Dose-dependent effects of recombinant human interleukin-6 on the pituitary-testicular axis. J Interferon Cytokine Res 19: 1271–1276
Weidler C, Holzer C, Harbuz M, Hofbauer R, Angele P, Scholmerich J, et al (2005) Low density of sympathetic nerve fibres and increased density of brain derived neurotrophic factor positive cells in RA synovium. Ann Rheum Dis 64: 13–20
Weidler C, Schmidt M, Perlick L, Schölmerich J, Straub RH (2004) Placental growth factor is linked to inflammation, vascularization, and DHEAS to DHEA conversion in synovial tissue of patients with rheumatoid arthritis. Arthritis Rheum 50 [Suppl]: S157
Yoshimura Y, Miyakoshi K, Hamatani T, Iwahashi K, Takahashi J, Kobayashi N, et al (1998) Role of beta 1 integrins in human endometrium and decidua during implantation. Horm Res 50 [Suppl] 2: 46–55
Ziche M, Maglione D, Ribatti D, Morbidelli L, Lago CT, Battisti M, et al (1997) Placenta growth factor-1 is chemotactic, mitogenic, and angiogenic. Lab Invest 76: 517–531
Ziche M, Morbidelli L, Pacini M, Dolara P, Maggi CA (1990) NK1-receptors mediate the proliferative response of human fibroblasts to tachykinins. Br J Pharmacol 100: 11–14
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Straub, R., Besedovsky, H. & del Rey, A. Warum gibt es analoge Krankheitsmechanismen bei chronisch entzündlichen Krankheiten?. Wien Klin Wochenschr 119, 444–454 (2007). https://doi.org/10.1007/s00508-007-0834-z
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s00508-007-0834-z