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Penalty term based suitable fuzzy intuitionistic possibilistic clustering: analyzing high dimensional gene expression cancer database


The aim of this paper is to identify the co-expressed potential genes that may serve for the development of the portions of normal or tumor. This paper differentiates the co-expressed genes into normal samples and tumor samples from gene expression dataset GSE25066. Since the dataset has vague boundaries and having common characteristics between the clusters, identifying the subgroups contain similar gene expression is really a tricky task one. Therefore, this paper introduces an effective fuzzy iterative clustering algorithm by incorporating kernel function, possibilistic c-means, fuzzy memberships, neighborhood information, median of neighboring objects and penalty term. The performances of the proposed clustering techniques have been shown through the succession experimental works on GSE25066. The effects of clustering results have been proved through comparing the resulted classes with ground truth.

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This work was financially supported by DST India and MOST Israel.

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Correspondence to S. R. Kannan.

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Kannan, S.R., Kashyap, E., Last, M. et al. Penalty term based suitable fuzzy intuitionistic possibilistic clustering: analyzing high dimensional gene expression cancer database. Soft Comput 25, 9839–9857 (2021).

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  • Fuzzy clustering
  • Big data
  • Neighboring objects
  • Cancer database
  • Penalty term