Soft Computing

, Volume 23, Issue 12, pp 3945–3963 | Cite as

Performing CTL model checking via DNA computing

  • Weijun ZhuEmail author
  • Yingjie Han
  • Qinglei Zhou


The computation using deoxyribonucleic acid (DNA) molecules provides an enormous parallel method that breaks through the limitations of the efficiency of traditional electronic computers. Model checking is a standard formal verification technique, which has been widely used in many fields of computation. It is also a well-known complex problem in computing theory. Until now, there is only one basic formula in the computation tree logic (CTL), for which model checking via DNA computing can be conducted. To this end, Adleman’s model based on DNA computing is used in this paper, based on which a series of DNA-computing-based model-checking algorithms to check the four basic CTL formulas are proposed. As a result, a core of the DNA version of the CTL model-checking problem is solved. The simulated experimental results show that the new algorithms are valid and can be properly implemented in molecular biology.


DNA computing Model checking Computation tree logic DNA molecules 



This study was partially funded by the National Natural Science Foundation of China under Grant Nos. U1204608 and 61572444 and China Postdoctoral Science Foundation under Grant No. 2015M572120.

Compliance with ethical standards

Conflict of interest

The authors of this paper declare that they have no conflicts of interest.

Ethical standard

This article does not contain any studies with human participants or animals performed by the authors.


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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.School of Information EngineeringZhengzhou UniversityZhengzhouChina

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