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Effect of heat stress on DNA damage: a systematic literature review

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Abstract

Thermal stress has a direct effect on various types of DNA damage, which depends on the stage of the cell cycle when the cell is exposed to different climate conditions. A literature review was conducted to systematically investigate and assess the overall effect of heat stress and DNA damage following heat exposure. In this study, electronic databases including PubMed, Scopus, and Web of Science were searched to find relevant literature on DNA damage in different ambient temperatures. Outcomes included (1) measurement of DNA damage in heat exposure, (2) three different quantification methods (comet assay, 8-hydroxy-2-deoxyguanosine (8-OHdG), and γ-H2AX), and (3) protocols used for moderate (31) and high temperatures (42). The evidence shows that long exposure and very high temperature can induce an increase in DNA damage through aggregate in natural proteins, ROS generation, cell death, and reproductive damage in hot-humid and hot-dry climate conditions. A substantial increase in DNA damage occurs following acute heat stress exposure, especially in tropical and subtropical climate conditions. The results of this systematic literature review showed a positive association between thermal stress exposure and inhibition of repair of DNA damage.

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Acknowledgements

The researchers express their gratitude to the School of Public Health Research Council of Tehran University of Medical Sciences, Tehran, Iran, for their advices and support.

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Authors and Affiliations

  1. Department of Occupational Health Engineering, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Peymaneh Habibi, Mohammad Reza Monazzam & Farideh Golbabaei

  2. Department of Pharmacology and Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

    Seyed Naser Ostad

  3. Department of Health in Disaster and Emergencies, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

    Ahad Heydari

  4. Artificial Intelligence Department, Smart University of Medical Sciences, Tehran, Iran

    Shima Aliebrahimi & Vahideh Montazeri

  5. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran

    Abbas Rahimi Foroushani

  6. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

    Mahmoud Ghazi-Khansari

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  1. Peymaneh Habibi
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Contributions

PH and AH participated in the study design and data collection. SNO, SA, and ARF participated in data analysis, manuscript writing, revising, and editing. Study was done under the supervision of FG and MRM. All authors read, revised, and approved the final manuscript.

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Correspondence to Farideh Golbabaei.

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Habibi, P., Ostad, S.N., Heydari, A. et al. Effect of heat stress on DNA damage: a systematic literature review. Int J Biometeorol 66, 2147–2158 (2022). https://doi.org/10.1007/s00484-022-02351-w

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