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The spatial distribution of the normal reference values of the activated partial thromboplastin time based on ArcGIS and GeoDA

International Journal of Biometeorology volume 64, pages 779–790 (2020)Cite this article

Abstract

We explored the variation and spatial distribution of the activated partial thromboplastin time (APTT) reference values of healthy people at different altitudes in China in order to develop a scientific basis for a unified standard. The APTT reference values of 49,020 healthy males (41–75 years old) and 32,447 healthy females (41–75 years old) were collected from 601 work units and 546 work units in China, respectively. The relationship between the APTT reference values and altitude was tested by correlation analysis. Linear regression analysis and curve analysis were employed to predict the APTT reference values in the whole country. Trend surface analysis, the variation function, kriging interpolation, and Getis-Ord Gi* statistic were utilized to reveal the spatial characteristics of the values. The result showed a significant positive correlation between the APTT reference values and altitude. The APTT values for females were prolonged for a greater amount of time than the males in several same areas in China. The spatial contact forms of the APTT reference values of healthy Chinese were mainly “high-high” and “low-low,” which was in accord with the first law of geography. The APTT reference values still showed spatial autocorrelation and regional variation. The values were higher in the western and northern areas than in the eastern and southern areas of China. The APTT reference values of people aged 41–75 in China showed regional differences. The APTT reference values in one area can be estimated by using the best prediction model or can be obtained by the geographical distribution.

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References

  • Ba J, Li SM, Ren XM, Hou WM, Bai WB, He WN, Yang HB (2007) Changes of indexes of hemorrheology and coagulative system of severe traumatic patients on highland Journal of Logistics University of CAPF. 16(1):49–52 (in Chinese)

  • Cliff AD, Ord JK (1981) Spatial processes, models and applications. Pion, London, pp 1–266

    Google Scholar 

  • Eikelboom JW, Hirsh J (2006) Monitoring unfractionated heparin with the aPTT: time for a fresh look. Thromb Haemost 96(11):547–552

    CAS  Article  Google Scholar 

  • Favaloro EJ, Lippi G (2018) Preanalytical issues that may cause misdiagnosis in haemophilia and von Willebrand disease. Heamophilia 24(2):198–210

    CAS  Article  Google Scholar 

  • Ge M (2002) Reference values of erythrocyte sedimentation rate of adult healthy subjects. Arch Med Res 33:506–509

    Article  Google Scholar 

  • Ge M (2004) Normal reference value of hemoglobin of infant girls and altitude in China. Arch Med Res 35:87–90

    Article  Google Scholar 

  • Ge M, Gu LL, He JW, Xue R, Yang S, Wang C, Fu H (2013) Normal reference value of whole blood viscosity (230s-1) of old women and geographical factors. Exp Gerontol 48:1449–1454

    Article  Google Scholar 

  • Goodchild MF (1987) A spatial analytical perspective on geographical information systems. Int J Geogr Inf Syst 1:327–344

    Article  Google Scholar 

  • Griffith D (2003) Spatial autocorrelation and spatial filtering: gaining understanding through theory and scientific visualization, 1st edn. Springer, New York, pp 3–246

  • Gu SQ (2016) The change of lymphocyte subsets, platelet and coagulation function in healthy person at different altitudes. Henan Journal of Surgery 29(7):700–703 (in Chinese)

    Google Scholar 

  • He JW, Ge M, Wang CX et al (2013) Predictive models and spatial variations of vital capacity in healthy people from 6 to 84 years old in China based on geographical factors. Int J Biometeorol 58:769–779

    Article  Google Scholar 

  • Hoerl AE, Kennard RW (1970) Ridge regression: biased estimation for nonorthogonal problems. Technometrics 12:55–72

    Article  Google Scholar 

  • Itagaki H, Hagino T (2019) Vitamin K deficiency-induced hemorrhagic shock after thoracentesis: a case report. BMC Gastroenterol 19(1):58–61

    Article  Google Scholar 

  • Ji XM, Meng R, Zhou J, Ling F, Jia J (2006) Dynamic change of coagulation and anticoagulation markers of patients with acute cerebral infarction during intravenous urokinase thrombolysis. Neurol Res 28(1):46–49

    CAS  Article  Google Scholar 

  • Jiang HF (2015) Monte Carlo simulation for probability and mathematical statistics based on SAS. China science and technology university press, Hefei, pp 1–4 (in Chinese)

    Google Scholar 

  • Justyna TC, Jacek S, Julia ZS et al (2019) Influence of glycemic control on coagulation and lipid metabolism in pregnancies complicated by pregestational and gestational diabetes mellitus. Adv Exp Med Biol 6:81–88

    Google Scholar 

  • Kitchen S, Jennings I, Woods TA, Preston FE (1996) Wide variability in the sensitivity of APTT reagents for monitoring of heparin dosage. J Clin Pathol 49(1):10–14

    CAS  Article  Google Scholar 

  • Kotwal J, Apte CV, Kotwal A, Mukherjee B, Jayaram J (2007) High altitude: a hypercoagulable state: results of a prospective cohort study. Thromb Res 120(3):391–397

    CAS  Article  Google Scholar 

  • Lars MA, Irmela S, Miha F et al (2002) Prekallikrein deficiency: the characteristic normalization of the severely prolonged aPTT following increased preincubation time is due to autoactivation of factor XII. Thromb Res 105:463–470

    Article  Google Scholar 

  • Li ZH, Luo P (2010) PASW/SPSS statistical analysis in Chinese version, 3rd edn. Publisher: Publishing House of Electronics Industry, Beijing, p 187 in Chinese

    Google Scholar 

  • Li T, Huang ZY, Wu QX (2012) Change and clinical significance of coagulation function in patients with acute pancreatitis. Henan Journal of Surgery 18(2):1–3 (in Chinese)

    Google Scholar 

  • Lin CH, Kuo YW, Kuo CY, Huang YC, Hsu CY, Hsu HL, Lin YH, Wu CY, Huang YC, Lee M, Yang HT, Pan YT, Lee JD (2015) Shortened activated partial thromboplastin time is associated with acute ischemic stroke, stroke severity, and neurological worsening. J Stroke Cerebrovasc Dis 24(10):2270–2276

    Article  Google Scholar 

  • Lisman T, Porte RJ (2017) Value of preoperative hemostasis testing in patients with liver disease for perioperative hemostatic management. Anesthesiology 126(2):338–344

    Article  Google Scholar 

  • Mou NX, Liu WB, Wang HY et al (2012) ArcGIS 10 tutorial: from beginner to master. Surveying and mapping publishing house, Beijing, pp 1–555 (in Chinese)

    Google Scholar 

  • Smythe MA, Forsyth LL, Warkentin TE, Smith MD, Sheppard JA, Shannon F (2015) Progressive, fatal thrombosis associated with heparin-induced thrombocytopenia after cardiac surgery despite “therapeutic” anticoagulation with argatroban: potential role for PTT and ACT confounding. J Cardiothorac Vasc Anesth 29(5):1319–1321

    Article  Google Scholar 

  • Suzuki K, Fukushima T, Meguro K, Aoki T, Kamezaki T, Saitoh H, Enomoto T, Nose T (1999) Intracranial hemorrhage in an infant owing to vitamin K deficiency despite prophylaxis. Childs Nerv Syst 15(6–7):292–294

    CAS  Article  Google Scholar 

  • Tobler WR (1970) A computer movie simulating urban growth in the Detroit region. Econ Geogr 46:234–240

    Article  Google Scholar 

  • Wheatley K, Creed M, Mellor A (2011) Haematological changes at altitude. Journal of the Royal Army Medical Corp 157(1):38–42

    CAS  Article  Google Scholar 

  • Xu JX (2009) Mathematical methods in Contemporary geography. Higher education press. Beijing, pp 98–105 (in Chinese)

  • Xu XF, Bi JP, Xu XG (2011) Spatial autocorrelation analyses on measles in Xiaoshan District of Hangzhou. Zhejiang preventive medicine 23(4):17–19 (in Chinese)

    Google Scholar 

  • Yan CN (1991) The encyclopedia of Chinese cities & counties. The Central Committee of C.P.C Party School Press, Beijing, pp 1–1446

    Google Scholar 

  • Yu CH (2007) SPSS and statistical analysis. Electronic Industry Press, Beijing, pp 141–146 (in Chinese)

    Google Scholar 

  • Zhang YB (1996) People with plateau. Qinghai people’s publishing house, Xining, pp 99–233 (in Chinese)

    Google Scholar 

  • Zhang X, Huang YG, Yu XR (2014) The effects of gender, age and body mass index on coagulability as measured by r-TEG. Chinese Journal of Blood Transfusion 27(3):288–290 (in Chinese)

    CAS  Google Scholar 

  • Zhao J, Chen CK (1999) Geography of China. Higher Education Press, Beijing, pp 1–382 (in Chinese)

    Google Scholar 

  • Zhao CT, Zhao ZW (1997) The clinical blood rheology. People’s Medical Publishing House, Beijing, pp 1–307 (in Chinese)

    Google Scholar 

  • Zhao SW, Wang YP, Xu LD, Gang W (2016) The application of thromboelastogram in detection of indexes of antiplatelet therapy for coronary heart disease. Journal of Thoracic Disease 8(12):3515–3520

    Article  Google Scholar 

  • Zhu HB, He LJ (2009) A study on appropriate conditions in consistency test of normal distribution by single sample K-S check in SPSS. Journal of capital institute of physical education 21(4):466–470 (in Chinese)

    Google Scholar 

  • Zhu H, Liu YB, You Y (2010) Monte Carlo method and quasi Monte Carlo method. East China University of Technology 33(4):357–362 (in Chinese)

    Google Scholar 

Download references

Funding

This work was supported by the National Natural Science Foundation of China (No. 40671005) and the Central College Fund (PhD) (No. GK201504015).

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Affiliations

  1. Institute of Healthy Geography, School of Geography and Tourism, Shaanxi Normal University, Xi’an, 710119, China

    Shaofang Yang, Miao Ge & Xiaoping Li

  2. Forest Inventory and Planning Institute in Guizhou, Guiyang, 550003, China

    Chiqin Pan

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  1. Shaofang Yang
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  2. Miao Ge
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  3. Xiaoping Li
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  4. Chiqin Pan
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Correspondence to Shaofang Yang.

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This study was approved by Medical Ethics Committee of Second Affiliated Hospital of Xi’an Jiaotong University medical school, and all subjects gave informed written consent (No. 2010-LS-009).

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We would like to submit our manuscript for publication on International Journal of Health Geographics.

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Yang, S., Ge, M., Li, X. et al. The spatial distribution of the normal reference values of the activated partial thromboplastin time based on ArcGIS and GeoDA. Int J Biometeorol 64, 779–790 (2020). https://doi.org/10.1007/s00484-020-01868-2

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  • DOI: https://doi.org/10.1007/s00484-020-01868-2

Keywords

  • APTT
  • Altitude
  • Trend surface analysis
  • Spatial distribution
  • Getis-Ord Gi*