Effects of high-temperature heat wave and ozone on hypertensive rats

Liang, Tingting; Niu, Jingping; Zhang, Shuyu; Song, Quanquan; Zhou, Ji

doi:10.1007/s00484-019-01788-w

Original Paper
Published: 21 May 2020

Effects of high-temperature heat wave and ozone on hypertensive rats

Tingting Liang ORCID: orcid.org/0000-0002-1434-9575¹,
Jingping Niu¹,
Shuyu Zhang^2,3,
Quanquan Song¹ &
Ji Zhou⁴

International Journal of Biometeorology volume 64, pages 1039–1050 (2020)Cite this article

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Abstract

This study aimed to investigate the effects of heat waves and ozone on hypertensive rats. Heat wave and ozone pollution were simulated on the Shanghai Meteorological and Environmental Animal Exposure System. Eighteen hypertensive rats were randomly divided into a control group, an ozone group, and a heat wave plus ozone group. The experimental groups were transferred to the exposure system for exposure to the ozone and heat wave plus ozone. After exposure, blood samples were collected from the abdominal aorta, and the hearts were harvested in all groups. The concentrations of inflammatory factors, vasomotion factors, cardiovascular risk factors, oxidative stress and thrombosis factors and heat stress factors in heart tissue were measured in each rat. Ozone exposure and heat wave plus ozone exposure increased the levels of inflammatory factors, thrombosis factors, vasomotion factors and cardiovascular risk factors, except for HDL-C, which was reduced. Moreover, experimental exposure increased the heat stress factors and oxidative stress, except for SOD, which was decreased. These data demonstrated that both ozone exposure and heat wave plus ozone exposure could adversely affect hypertensive rats, and that heat wave may enhance the toxic effect of ozone exposure.

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Funding

This study was supported by grants from the National Natural Science Foundation of China (41375121), the Key Research Project of Hebei Province (18273705D), Shanghai Meteorological Bureau, and Key Laboratory of Meteorology and Ecological Environment of Hebei Province.

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Affiliations

Lanzhou University, Lanzhou, 730000, China
Tingting Liang, Jingping Niu & Quanquan Song
Hebei Provincial Meteorological Bureau, Shijiazhuang, 050021, China
Shuyu Zhang
Key Laboratory of Meteorology and Ecological Environment of Hebei Province, Shijiazhuang, 050021, China
Shuyu Zhang
Yangtze River Delta Environmental Weather Forecast Center, Shanghai, 200000, China
Ji Zhou

Authors

Tingting Liang
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Jingping Niu
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Shuyu Zhang
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Quanquan Song
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Ji Zhou
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Contributions

Shuyu Zhang conceived the study idea and designed the experiments; Tingting Liang, Quanquan Song and Ji Zhou performed the experiments and acquired data; Tingting Liang and Shuyu Zhang wrote the manuscript; Jingping Niu edited and revised the manuscript.

Corresponding author

Correspondence to Shuyu Zhang.

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The authors declare that there is no conflict of interest.

Ethics statement

The animal protocols used in this work were evaluated and approved by the Animal Use and Ethic Committee of Hebei Provincial Meteorological Bureau (Protocol No. 2014_1). They are in accordance with Guidance Suggestions for the Care and Use of Laboratory Animals (issued by the Ministry of Science and Technology of the People’s Republic of China, document No.2006_398) and the Regulations for Laboratory Animal Management (revised by Decree of the State Council of the People’s Republic of China, No. 638).

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Highlights

1. First time to evaluate the effects of high-temperature heat wave plus ozone on hypertensive rats

2. An actual high-temperature heat wave and ozone pollution were simulated on the Shanghai Meteorological and Environmental Animal Exposure System on the basis of heat wave and ozone pollution data collected in July 2017 in Shijiazhuang, China.

3. Heat wave may enhance the toxic effect of ozone exposure on hypertensive rats.

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Liang, T., Niu, J., Zhang, S. et al. Effects of high-temperature heat wave and ozone on hypertensive rats. Int J Biometeorol 64, 1039–1050 (2020). https://doi.org/10.1007/s00484-019-01788-w

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Received: 30 September 2018
Revised: 02 July 2019
Accepted: 13 August 2019
Published: 21 May 2020
Issue Date: July 2020
DOI: https://doi.org/10.1007/s00484-019-01788-w

Keywords

Heat wave
Ozone
Hypertension
Cardiovascular disease