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Botulinumtoxin-A-Injektionen bei neuropathischem Schmerz

Eine Post-hoc-Subgruppenanalyse bei Patienten mit peripherer Nervenverletzung

Botulinum toxin A injections in neuropathic pain

A post-hoc subgroup analysis of patients with peripheral nerve injury

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Zusammenfassung

Nach subkutan injiziertem Botulinumtoxin A zeigte sich bei neuropathischem Schmerz in der hier vorgestellten Originalarbeit nach 24 Wochen eine der Placebogabe signifikant überlegene Schmerzlinderung, die mittels einer neu durchgeführten post-hoc Analyse auch für die Subgruppe der 46 Patienten mit peripherer Nervenverletzung nachweisbar war. Relevante Nebenwirkungen traten in der gesamten randomisierten kontrollierten Studie nicht auf.

Abstract

The randomized controlled trial (RCT) presented in this article showed significant relief in neuropathic pain following subcutaneous injections of botulinum toxin A over 24 weeks compared to placebo. This result was confirmed in a novel post-hoc analysis of the subgroup of 46 patients with peripheral nerve injury. Relevant adverse effects did not occur during the RCT.

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Authors and Affiliations

  1. Abteilung für Schmerzmedizin, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil gGmbH, Ruhr-Universität Bochum, Bürkle de la Camp-Platz 1, 44789, Bochum, Deutschland

    L. Eitner, J. Vollert & C. Maier

  2. INSERM U‑987, Centre d’Evaluation et de Traitement de la Douleur, Hôpital Ambroise Paré, AP-HP, Boulogne-Billancourt, Université Versailles-Saint-Quentin, Paris, Frankreich

    N. Attal

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  1. L. Eitner
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  2. J. Vollert
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  3. C. Maier
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  4. N. Attal
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Correspondence to L. Eitner.

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Interessenkonflikt

L. Eitner, J. Vollert, C. Maier und N. Attal geben an, dass kein Interessenkonflikt besteht.

Die in diesem Beitrag beschriebenen Untersuchungen am Menschen wurden gemäß der Deklaration von Helsinki von 1975 sowie mit Zustimmung der zuständigen Ethikkommission durchgeführt.

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Eitner, L., Vollert, J., Maier, C. et al. Botulinumtoxin-A-Injektionen bei neuropathischem Schmerz. Schmerz 31, 524–526 (2017). https://doi.org/10.1007/s00482-017-0235-9

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  • DOI: https://doi.org/10.1007/s00482-017-0235-9

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