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Bildgebung und Schmerz

Imaging techniques and pain

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Zusammenfassung

Die Anwendung der funktionellen Bildgebung in der Schmerzforschung erlaubte in den vergangenen 15 Jahren erstmals Einblicke in die bis dahin unzugänglichen Prozesse der kortikalen, subkortikalen und jüngst sogar spinalen Schmerzverarbeitung im Menschen und hat unser Verständnis bezüglich der Mechanismen der zentralen Schmerzverarbeitung und -modulation entscheidend beeinflusst. Hieran hatten Arbeiten aus Deutschland auch aus internationaler Perspektive einen maßgeblichen Anteil. Die zentrale Herausforderung der nächsten Jahre ist die stärkere Fokussierung auf verschiedene Patientengruppen mit chronischen Schmerzerkrankungen, um die Mechanismen der Schmerzchronifizierung sowie individuelle neurobiologische Prädiktoren und Schutzfaktoren durch den Einsatz multimodaler bildgebender Verfahren besser zu verstehen. Ziel dieser Untersuchungen sollte sein, individuelle oder syndromspezifische zentralnervöse Veränderungen im Sinne eines Biomarkers für therapeutische Entscheidungen heranzuziehen.

Abstract

Over the last 15 years, functional brain imaging techniques have provided critical insights into cortical, subcortical and even spinal mechanisms involved in pain perception and pain modulation in humans. The pivotal contribution of brain imaging studies conducted in Germany have thereby been internationally acknowledged. One of the key challenges for the next decade is to shift the focus from studies in healthy volunteers to different clinical populations suffering from chronic pain to characterize CNS mechanisms, as well as neurobiological predictors and resilience factors of pain chronification. Ultimately, the knowledge gained by this work may help identify individual or syndrome-specific CNS changes as biomarkers to make therapeutic decisions.

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Authors and Affiliations

  1. Klinik für Neurologie und Neurophysiologie, Klinikum Fürth, Fürth, Deutschland

    C. Maihöfner

  2. Klinik für Neurologie, Universitätsklinikum Essen, Hufelandstr. 55, 45147, Essen, Deutschland

    U. Bingel

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Correspondence to U. Bingel.

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C. Maihöfner und U. Bingel geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Maihöfner, C., Bingel, U. Bildgebung und Schmerz. Schmerz 29, 539–543 (2015). https://doi.org/10.1007/s00482-015-0053-x

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  • DOI: https://doi.org/10.1007/s00482-015-0053-x

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