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Direkte Hemmung von TRPV1 durch Acetylsalicylsäure

Neue Wirkung eines alten Medikaments

Direct inhibition of TRPV1 by acetylsalicylic acid

New effect of an old drug

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Literatur

  1. Bhave G, Zhu W, Wang H et al (2002) cAMP-dependent protein kinase regulates desensitization of the capsaicin receptor (VR1) by direct phosphorylation. Neuron 35:721–731

    Article  CAS  PubMed  Google Scholar 

  2. Caterina MJ, Schumacher MA, Tominaga M et al (1997) The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389:816–824

    Article  CAS  PubMed  Google Scholar 

  3. Gavva NR (2008) Body-temperature maintenance as the predominant function of the vanilloid receptor TRPV1. Trends Pharmacol Sci 29:550–557

    Article  CAS  PubMed  Google Scholar 

  4. Greffrath W (2006) The capsaicin receptor. „TRPing“ transduction for painful stimuli. Schmerz 20:219–225

    Article  CAS  PubMed  Google Scholar 

  5. Greffrath W, Kirschstein T, Nawrath H et al (2002) Acetylsalicylic acid reduces heat responses in rat nociceptive primary sensory neurons – evidence for a new mechanism of action. Neurosci Lett 320:61–64

    Article  CAS  PubMed  Google Scholar 

  6. Hunskaar S, Berge OG, Hole K (1986) Dissociation between antinociceptive and anti-inflammatory effects of acetylsalicylic acid and indomethacin in the formalin test. Pain 25:125–132

    Article  CAS  PubMed  Google Scholar 

  7. Koplas PA, Rosenberg RL, Oxford GS (1997) The role of calcium in the desensitization of capsaicin responses in rat dorsal root ganglion neurons. J Neurosci 17:3525–3537

  8. Kress V, Reeh PW (1996) Inhibition of a capsaicin induced ionic current – a new mechanism of action for aspirin-like drugs? Pflügers Arch 431

  9. Maurer K, Binzen U, Mörz H et al (2014) Acetylsalicylic acid enhances tachyphylaxis of repetitive capsaicin responses in TRPV1-GFP expressing HEK293 cells. Neurosci Lett 563:101–106

    Article  CAS  PubMed  Google Scholar 

  10. Mohapatra DP, Nau C (2005) Regulation of Ca2 +-dependent desensitization in the vanilloid receptor TRPV1 by calcineurin and cAMP-dependent protein kinase. J Biol Chem 280:13424–13432

  11. Rainsford KD (2007) Anti-inflammatory drugs in the 21st century. Subcell Biochem 42:3–27

    Article  CAS  PubMed  Google Scholar 

  12. Treede RD, Wagner T, Kern KU et al (2013) Mechanism- and experience-based strategies to optimize treatment response to the capsaicin 8 % cutaneous patch in patients with localized neuropathic pain. Curr Med Res Opin 29:527–538

    Article  CAS  PubMed  Google Scholar 

  13. Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 231:232–235

    Article  CAS  PubMed  Google Scholar 

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Danksagung

Die Arbeit wurde durch ein Promotionsstipendium der Deutschen Gesellschaft zum Studium des Schmerzes für K. Maurer gefördert.

Einhaltung ethischer Richtlinien

Interessenkonflikt. R.-D. Treede erhielt Forschungsmittel, Vortrags- und Beraterhonorare von Allergan, Astellas, AWD, Boehringer Ingelheim, dem Bundesministerium für Bildung und Forschung, der Deutschen Forschungsgemeinschaft, GlaxoSmithKline, Grünenthal, Kade, Lily, Merz, Mundipharma, Nycomed, Pfizer, Sanofi, StarMedTec, Schwarz und den US National Institutes of Health. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Lehrstuhl für Neurophysiologie, Centrum für Biomedizin und Medizintechnik Mannheim (CBTM), Universitätsmedizin Mannheim, Medizinische Fakultät Mannheim, Universität Heidelberg, Ludolf-Krehl-Str. 13–17, 68167, Mannheim, Deutschland

    K. Maurer, U. Binzen, H. Mörz, R.-D. Treede &  W. Greffrath

Authors
  1. K. Maurer
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  2. U. Binzen
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  3. H. Mörz
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  4. R.-D. Treede
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  5. W. Greffrath
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Corresponding author

Correspondence to W. Greffrath.

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Maurer, K., Binzen, U., Mörz, H. et al. Direkte Hemmung von TRPV1 durch Acetylsalicylsäure. Schmerz 29, 223–226 (2015). https://doi.org/10.1007/s00482-014-1492-5

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  • DOI: https://doi.org/10.1007/s00482-014-1492-5

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