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Intrinsische Hirnaktivität bei Schmerzen

Intrinsic brain activity with pain

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Zusammenfassung

Neben der Antwort auf nozizeptive Schmerzreize sind auch andere neurale Funktionsmodi des Gehirns zum umfassenden Verständnis der Schmerzverarbeitung beim Menschen notwendig. Ohne Stimulation generiert das Gehirn spontan niederfrequente Wellen neuronaler Aktivität und organisiert sich endogen in verschiedenen Netzwerken. In dieser Übersicht werden die erst in jüngster Zeit akkumulierenden neurobiologischen Erkenntnisse zu dieser intrinsischen Hirnaktivität zusammengefasst und in Beziehung zu akutem sowie chronischem Schmerzgeschehen gesetzt.

Abstract

Besides the responses to nociceptive stimuli other neural function modes of the brain are necessary to obtain a comprehensive understanding of pain processing in humans. During a resting state without extrinsic stimulation the human brain generates spontaneous low frequency fluctuations of neural activity. This intrinsic activity does not reflect random background noise but is highly organized in several networks. Based on the findings of recent functional imaging studies, the role of these resting state networks in acute and chronic pain is discussed.

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  1. Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Klinikum rechts der Isar, Technische Universität München, München, Deutschland

    A. Otti

  2. Abteilung für Neuroradiologie , Klinikum rechts der Isar, Technische Universität München, München, Deutschland

    A. Otti

  3. Klinik und Poliklinik für Psychosomatische Medizin und Psychotherapie, Universitätsklinikum Ulm, Am Hochsträß 8, 89081, Ulm, Deutschland

    M. Noll-Hussong

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Otti, A., Noll-Hussong, M. Intrinsische Hirnaktivität bei Schmerzen. Schmerz 25, 501–507 (2011). https://doi.org/10.1007/s00482-011-1097-1

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