Migräne und Hormone: Was ist gesichert?

Migraine and hormones: what can we be certain of?

Zusammenfassung

Frauen leiden häufiger an Migräne als Männer. Dieses Ungleichgewicht ist bei gleicher genetischer Disposition u. a. in zusätzlichen Triggerfaktoren wie den natürlichen Schwankungen im weiblichen Hormonhaushalt begründet. Der Einfluss der weiblichen Geschlechtshormone auf Migräne wird neben der unterschiedlichen Häufigkeiten der Migräne von Männern und Frauen durch die fluktuierende Migräneprävalenz innerhalb des Lebens und des monatlichen Hormonzyklus der Frau illustriert. Dazu gehören das Phänomen der menstruellen Migräne, der überwiegend positive Verlauf der Migräne bei stabilen Hormonverhältnissen wie in Schwangerschaft, Stillzeit und nach der Menopause, sowie der Einfluss exogen zugeführter Hormone wie der Pille oder einer postmenopausalen Hormonersatztherapie auf die Migränefrequenz. Zusammenfassend bekräftigen epidemiologische, klinische und experimentelle Untersuchungen einen wesentlichen Einfluss der weiblichen Geschlechtshormone auf die Pathophysiologie der Migräne.

Abstract

Women suffer from migraine far more frequently than men. This sex difference during the reproductive years is considered to result from additional trigger factors, such as the fluctuating hormones of the menstrual cycle and with the reproductive milestones of women. The role of the female hormones on migraine is illustrated by the phenomenon of menstrual migraine, and the changes in the clinical course of migraine with menarche, pregnancy, menopause and the external application of hormones. In summary, epidemiological, clinical and experimental studies document a substantial influence of female sex hormones on the pathophysiology of migraine headache.

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Bingel, U. Migräne und Hormone: Was ist gesichert?. Schmerz 22, 31–36 (2008). https://doi.org/10.1007/s00482-007-0613-9

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Schlüsselwörter

  • Kopfschmerzen
  • Hormone
  • Migräne
  • Schwangerschaft
  • Menopause
  • Menstruelle Migräne

Keywords

  • Headache
  • Hormones
  • Migraine
  • Pregnancy
  • Menopause
  • Menstrual migraine