Zusammenfassung
Hintergrund
In der Vergangenheit war es schwierig, die zentrale Verarbeitung primärer C-Faser-Afferenzen separat von der Verarbeitung von Aδ-Faser-Afferenzen zu untersuchen. Eine notwendige und hinreichende Bedingung für eine Untersuchung des C-Faser-Systems ist die selektive Stimulation der primären C-Faser-Afferenz bei gleichzeitiger Vermeidung der Aktivierung der Aδ-Afferenz. Die Stimulation winziger Hautareale ermöglicht eine solche selektive Aktivierung der C-Fasern.
Methoden und Ergebnisse
Wesentliche methodische Aspekte der Stimulation winziger Hautareale sowie Ergebnisse zu evozierten Potenzialen und deren Quellenlokalisationen werden referiert. Des Weiteren werden Potenzial und Möglichkeiten dieser Methode mit anderen Methoden zur Untersuchung der zentralen Verarbeitung humaner C-Faser-Afferenzen verglichen.
Schlussfolgerung
Mit der Methode der Stimulation winziger Hautareale steht ein einfaches Verfahren der selektiven Stimulation von C-Fasern zur Verfügung.
Abstract
Background
It has been found difficult to stimulate the primary C-fibre afferents separately from those of Aδ fibres. A necessary and sufficient condition for the investigation of the C-fibre system is the selective stimulation of C fibres without activation of Aδ fibres. The stimulation of tiny skin areas allows such a selective activation of C fibres.
Methods and results
The main aspects of the method for stimulation of tiny skin areas as well as some results obtained by this method are reported here. The application of this method is compared with applications of other methods that allow an investigation of central processing of human C-fibre input.
Conclusion
The stimulation of tiny skin areas represents a simple method for selective stimulation of C fibres.
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Danksagung
Wir danken Prof. Leon Plaghki und Dr. Emmanuelle Opsommer (Université Catholique de Louvain), die im Rahmen einer Kooperation die Übernahme der Methode der Stimulation winziger Hautareale in unser Labor ermöglichten.
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Weiss, T., Miltner, W.H.R. Selektive C-Faser-Stimulation durch Stimulation winziger Hautareale. Schmerz 20, 238–244 (2006). https://doi.org/10.1007/s00482-005-0416-9
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DOI: https://doi.org/10.1007/s00482-005-0416-9