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Therapie chronischer Schmerzen mit oralem retardiertem Oxycodon

Behandlungsdaten von 4196 Patienten

Oral controlled-release oxycodone for the treatment of chronic pain

Data from 4196 patients

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Zusammenfassung

Seit 1998 steht in Deutschland orales retardiertes Oxycodon zur Behandlung chronischer Schmerzen zur Verfügung. In kontrollierten Studien wurde in den USA und anderen europäischen Ländern eine gute Sicherheit und Wirksamkeit von Oxycodon dargestellt. In dieser Arbeit werden die Ergebnisse aus 6 prospektiven Beobachtungsstudien vorgestellt. Insgesamt 4196 Patienten mit chronischen Schmerzen unterschiedlicher Ursache wurden überwiegend ambulant von nichtspezialisierten Ärzten 3–4 Wochen mit oralem, retardiertem Oxycodon behandelt und beobachtet. Bei 356 Patienten mit Schmerzen des Bewegungsapparats wurde die Schmerzbehandlung über 6 Monate beobachtet. Die häufigsten Gründe für einen Therapieabbruch waren unzureichende Analgesie, Nebenwirkungen oder Noncompliance. Die Akzeptanz der Medikation durch Arzt und Patient war sehr gut, die Beeinträchtigung der verschiedenen Lebensbereiche besserte sich deutlich. Die Anwendung von retardiertem Oxycodon war eine sichere und effektive Therapie auch für nicht in der Schmerztherapie spezialisierte Ärzte.

Abstract

Oral controlled-release oxycodone has been available for the treatment of chronic pain in Germany since 1998. Controlled trials have shown good clinical efficacy and tolerability. This survey reports results from six open prospective multicenter trials. In these trials 4196 patients suffering from cancer pain and non-cancer-related pain with inadequate pain relief were treated with oral controlled-release oxycodone for 3–4 weeks. Only a few participating physicians were pain specialists. A total of 356 patients suffering from pain of the musculoskeletal system and receiving oxycodone therapy were monitored for 6 months. Exclusion from the studies was due mainly to inadequate analgesia, side effects, and noncompliance. The efficacy of oxycodone was rated to be better than moderate by most of the patients, quality of life parameters increased significantly, and patient satisfaction was high. The treatment with oral controlled-release oxycodone was a safe and effective option even when used by nonspecialized physicians.

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Interessenkonflikt:

Die Präsentation der Daten auf dem Deutschen Schmerzkongress in Münster 2003 wurde von der Firma Mundipharma unterstützt.

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Authors and Affiliations

  1. Klinik für Anästhesiologie und operative Intensivmedizin, Klinikum der Universität zu Köln

    J. Gaertner, R. Sabatowski & T. Giesecke

  2. Medizinische Abteilung, Mundipharma Research GmbH Limburg

    M. Frank & B. Bosse

  3. Klinik für Palliativmedizin, Universitätsklinikum Aachen

    F. Elsner & L. Radbruch

  4. Klinik für Anästhesiologie und operative Intensivmedizin, Klinikum der Universität, 50924 , Köln

    J. Gaertner

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  1. J. Gaertner
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  2. M. Frank
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  3. B. Bosse
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  4. R. Sabatowski
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  5. F. Elsner
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  6. T. Giesecke
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  7. L. Radbruch
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Correspondence to J. Gaertner.

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Gaertner, J., Frank, M., Bosse, B. et al. Therapie chronischer Schmerzen mit oralem retardiertem Oxycodon. Schmerz 20, 61–68 (2006). https://doi.org/10.1007/s00482-005-0396-9

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  • DOI: https://doi.org/10.1007/s00482-005-0396-9

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