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Estimating birth and death rates from cell labeling data

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Abstract

The objective of this article is to provide a statistical method for estimating both birth and death rates from labeling data. Current practice of estimating cell division (birth) rate α by the formula LI(t) = 1 − exp(−2αt) suggests that the use of labeling index (LI) as a cell proliferation indicator may incur loss of valuable information inherited in the data that are used to calculate the index. Information about cell death has become increasingly important for understanding a disease processes, and for developing a biologically based dose-response model for environmental health risk assessments. Simple stochastic and deterministic models are proposed for estimating both birth and death rates simultaneously from labeling data.

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Authors and Affiliations

  1. National Center for Environmental Assessment, U.S. Environmental Protection Agency, 1200 Pennsylvania Avenue, NW, Washington, DC, 20460, USA

    Chao W. Chen

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  1. Chao W. Chen
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Correspondence to Chao W. Chen.

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The views expressed in this article are those of the author and do not necessarily reflect the views of the U.S. Environmental Protection Agency.

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Chen, C.W. Estimating birth and death rates from cell labeling data. Stoch Environ Res Risk Assess 23, 621–626 (2009). https://doi.org/10.1007/s00477-008-0247-1

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  • DOI: https://doi.org/10.1007/s00477-008-0247-1

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