Skip to main content

Advertisement

SpringerLink
Log in

Visualization of gold nanoparticle on the microscopic picture of red blood cell: implication for possible risk of nanoparticle exposure

  • Original Paper
  • Published:
Stochastic Environmental Research and Risk Assessment Aims and scope Submit manuscript

Abstract

In medicine, there is limited knowledge on the toxicity of nanoparticles. In reproductive medicine, there has been limited knowledge on the effect of gold nanoparticle on the human red blood cell. In this work, the author performed a study to demonstrate if gold nanoparticle can be detected inside red blood cell on microscopic test. Chulalongkorn Univesity, Bangkok Thailand. This study was performed as an experimental study. Mixture of gold nanoparticle solution and blood sample was prepared and further analyzed. According to this work, accumulation of gold nanoparticle in the red blood cell can be observed after mixing the blood sample with gold nanoparticle solution. However, no significant destruction of the red cell can be seen. The effect of gold nanoparticle on red blood cell can be detected and the implication for the possible chronic toxicity of the accumulated gold nanoparticle in red cell is raised.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

Notes

  1. Nanoparticles hitchhike on red blood cells: a potential new method for drug delivery. Exp Biol Med (Maywood) 232(7):fmvi, 2007

References

  • Haruta M (2003) When gold is not noble: catalysis by nanoparticles. Chem Rec 3(2):75–87

    Article  CAS  Google Scholar 

  • Oberdörster G, Oberdörster E, Oberdörster J (2005) Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect 113(7):823–839

    Article  CAS  Google Scholar 

  • Rothen-Rutishauser BM, Schurch S, Haenni B, Kapp N, Gehr P (2006) Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques. Environ Sci Technol 40(14):4353–4359

    Article  CAS  Google Scholar 

  • Seaton A (2006) Nanotechnology and the occupational physician. Occup Med (Lond) 56(5):312–316

    Article  Google Scholar 

  • Soler MA, Bao SN, Alcantara GB, Tiburcio VH, Paludo GR, Santana JF, Guedes MH, Lima EC, Lacava ZG, Morais PC (2007) Interaction of erythrocytes with magnetic nanoparticles. J Nanosci Nanotechnol 7(3):1069–1071

    Article  CAS  Google Scholar 

  • Thrall L (2006) Are red blood cells defenseless against smaller nanoparticles? Environ Sci Technol 40(14):4327–4328

    Article  CAS  Google Scholar 

  • Tseng WL, Lee KH, Chang HT (2005) Using nile red-adsorbed gold nanoparticles to locate glutathione within erythrocytes. Langmuir 21(23):10676–10683

    Article  CAS  Google Scholar 

  • Wiwanitkit V, Soogarun S, Suwansaksri J (2007) A correlative study on red blood cell parameters and urine trans, trans-muconic acid in subjects with occupational benzene exposure. Toxicol Pathol 35(2):268–269

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Clinical Laboratory Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand

    Viroj Wiwanitkit

  2. Division of Histology and Cell Biology, Department of Anatomy, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

    Amornpun Sereemaspun

  3. Sensor Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand

    Rojrit Rojanathanes

Authors
  1. Viroj Wiwanitkit
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Amornpun Sereemaspun
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rojrit Rojanathanes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Viroj Wiwanitkit.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wiwanitkit, V., Sereemaspun, A. & Rojanathanes, R. Visualization of gold nanoparticle on the microscopic picture of red blood cell: implication for possible risk of nanoparticle exposure. Stoch Environ Res Risk Assess 22, 583–585 (2008). https://doi.org/10.1007/s00477-007-0177-3

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00477-007-0177-3

Keywords

Search

Navigation