Skip to main content

Advertisement

Log in

Early urinary changes in Tamm-Horsfall protein and epidermal growth factor in diabetic children

  • Original Article
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract 

Both glomerular and tubular markers have been used to follow diabetic nephropathy. However, neither albumin nor proximal tubular markers have proven useful in prepubertal diabetes. Hence we studied two markers derived from the distal tubular cells, Tamm-Horsfall protein (THP) and epidermal growth factor (EGF). The urinary excretion of THP and EGF was examined in samples obtained during the first 20 days and 1 year after diagnosis of diabetes in children aged 4–15 years. Fourteen children without and 18 with ketonuria were examined, and 17 age-matched healthy children participated as controls. The excretion rate of EGF was increased at diagnosis, while that of THP was not. After 20 days of treatment the excretion of EGF had normalized, while the excretion of THP was decreased. Similar results were obtained after 1 year. In conclusion, in spite of good metabolic control a reduced excretion of THP persisted for at least 1 year after the diagnosis of diabetes. Whether the finding of reduced excretion of THP has any biological significance awaits further study.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

Author information

Authors and Affiliations

Authors

Additional information

Received: 21 July 2000 / Revised: 16 January 2001 / Accepted: 17 January 2001

Rights and permissions

Reprints and permissions

About this article

Cite this article

Holmquist, P., Torffvit, O., Jørgensen, P. et al. Early urinary changes in Tamm-Horsfall protein and epidermal growth factor in diabetic children. Pediatr Nephrol 16, 488–492 (2001). https://doi.org/10.1007/s004670100587

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s004670100587

Navigation