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Pediatric Nephrology

, Volume 13, Issue 7, pp 594–596 | Cite as

Etiology and outcome of chronic renal failure in Indian children

  • S. Gulati
  • Sanjay Mittal
  • Raj Kumar Sharma
  • Amit Gupta
Original Article

Abstract 

A prospective analysis of all new pediatric cases of chronic renal failure (CRF) was performed at our hospital over a 1-year period. The diagnosis of CRF was based on serum creatinine >2 mg/dl with supportive clinical, laboratory, and radiological findings. There were a total of 48 patients with CRF with a median age of 13 years (range 10 days to 16 years). The causes of CRF included glomerulonephritis (37.5%), obstruction and interstitial (52%), hereditary (6.3%), and undetermined (4.2%). Patients were symptomatic for a mean of 33.2 months (range 10 days to 11 years) at presentation. Eight patients (16.7%) had acute reversible deterioration of renal function at presentation. This was due to accelerated hypertension in 2, infection in 3, volume depletion in 2, and nonsteroidal antiinflammatory drugs in 1 patient. At presentation, 22 (46%) children had mild to moderate renal failure and 26 (54%) had end-stage renal disease. Twenty-one children (43.7%) had associated illness at presentation. Mean follow-up was 22.9 weeks (range 2–126 weeks). At the end of the study period, 10 (21%) patients were on conservative treatment, 7 (14.6%) on maintenance dialysis, 8 (16.7%) patients had functioning allografts, 4 (8.3%) patients had died, and 19 (39.6%) opted against further therapy. We conclude that CRF in Indian children carries a poor prognosis due to late referral and the limited availability and high cost of renal replacement therapy.

Key words Chronic renal failure Dialysis Transplantation Indian children 

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Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 1999

Authors and Affiliations

  • S. Gulati
    • 1
  • Sanjay Mittal
    • 1
  • Raj Kumar Sharma
    • 1
  • Amit Gupta
    • 1
  1. 1.Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow – 226014, UP, India, e-mail: sgulati@sgpgi.ac.inIN

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