Abstract.
Humoral hypercalcemia refers to the elevated blood calcium levels caused by neoplasms which release a bone resorptive substance into the circulation. Previously reported infants with malignant and benign solid tumors causing humoral hypercalcemia have presented with large abdominal masses. The case we describe, a hypercalcemic infant due to an occult parathyroid hormone-related protein-containing metanephric adenoma of the kidney, shows that radionuclide bone scanning can be a useful test to identify humoral hypercalcemia. Humoral hypercalcemia stemming from a soft tissue neoplasm should be ruled out, even in the absence of clinical signs of a tumor, if bone scans show generalized uptake in the absence of hypervitaminosis D or radiological signs of bone lesions, and serum parathyroid hormone is low.
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Received July 1, 1996; received in revised form and accepted December 10, 1996
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Mahoney, C., Cassady, C., Weinberger, E. et al. Humoral hypercalcemia due to an occult renal adenoma. Pediatr Nephrol 11, 339–342 (1997). https://doi.org/10.1007/s004670050291
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DOI: https://doi.org/10.1007/s004670050291