The detection of murine autosomal recessive polycystic kidney disease using real-time ultrasound

Abstract.

Using currently available ultrasound equipment, 38 BPK and CPK mice were evaluated at 7 days of age for the presence of autosomal recessive polycystic kidney disease (ARPKD). The kidneys were less echogenic than adjacent soft tissues and measured between 5.1 and 6.3 mm from pole to pole in 32 unaffected mice and 1 with ARPKD. In 5 mice with ARPKD, the kidneys were similar in echogenicity to adjacent soft tissues and measured between 6.9 and 8.4 mm from pole to pole. Renal sonography is able to identify most mice with polycystic kidney disease prior to the development of abdominal enlargement and laboratory abnormalities, and shows promise for future applications in animal research.