Abstract.
We investigated the pattern of functional renal maturation and electrolyte handling on postnatal day 1 (PD1), day 5 (PD5), and day 12 (PD12) in rat neonates, after mothers were given furosemide during pregnancy. The drug was administered (75 mg/kg per day i. p.) on day 7 – 11 (organogenesis) and 14 – 18 (nephrogenesis) of gestation. On PD1 and PD5, there was a disturbance of the urinary concentrating ability with a hyperdiuresis and an overstimulated ionic exchange, mainly the distal sodium reabsorption. From PD1 to PD12, a progressive functional recovery in electrolyte handling appeared. However, on PD12, when nephrogenesis was achieved, the renal concentrating defect remained. We discuss the possibility of a drug-induced delay in the development of the loop of Henle, leading to functional and morphological adaptations of already developed parts of the nephron.
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Received January 24, 1995; received in revised form and accepted November 27, 1995
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Mallie, J., Boudzoumou, P. Functional renal maturation in rat neonates after prenatal exposure to furosemide. Pediatr Nephrol 10, 458–460 (1996). https://doi.org/10.1007/s004670050139
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DOI: https://doi.org/10.1007/s004670050139