Abstract
. Neutrophil-mediated tissue damage has been implicated in the pathogenesis of diarrhoea-associated haemolytic uraemic syndrome (D+ HUS). This study evaluates priming and activation of the neutrophil oxidative burst in D+ HUS using chemiluminescent techniques. Peripheral blood neutrophils from 11 children with acute D+ HUS were examined. No difference was found in the oxidative burst of neutrophils from patients and controls. Serum elastase levels were measured in 8 patients and found to be significantly elevated. Although elastase results suggest neutrophil activation, chemiluminescence studies do not confirm this in the peripheral blood neutrophil. This does not support a significant role for circulating agents in priming and activating the peripheral blood neutrophil.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received August 17, 1995; received in revised form and accepted November 27, 1995
Rights and permissions
About this article
Cite this article
Hughes, D., Smith, G., Davidson, J. et al. The neutrophil oxidative burst in diarrhoea – associated haemolytic uraemic syndrome. Pediatr Nephrol 10, 445–447 (1996). https://doi.org/10.1007/s004670050136
Issue Date:
DOI: https://doi.org/10.1007/s004670050136