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Two novel alternatively spliced 9-bp exons in the COL4A5 gene

  • Genetic Renal Disease / Brief Report
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract 

The existence of an alternatively used 18-bp sequence has been described in type IV collagen α5 chain mRNA from human kidney (Guo et al., Kidney Int 44, 1993). In this study we have shown that this sequence is encoded by two exons, termed 41A and 41B, that are located in a 9-kb intron 41 that was sequenced in its entirety. The sequences of exon 41A and 41B were shown to be present in mRNAs from a variety of tissues.

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Authors and Affiliations

  1. Biocenter Oulu and Department of Biochemistry, University of Oulu, Linnanmaa, 90570 Oulu, Finland, , , , , , FI

    Paula H. Martin

  2. Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Doktorsringen 9A3, Karolinska Institute, 171 77 Stockholm, Sweden e-mail: karl.tryggvason@mbb.ki.se Tel.: +46-8-7287720, Fax: +46-8-316165, , , , , , SE

    K. Tryggvason

Authors
  1. Paula H. Martin
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  2. K. Tryggvason
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Received: 13 April 2000 / Revised: 20 June 2000 / Accepted: 20 June 2000

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Martin, P., Tryggvason, K. Two novel alternatively spliced 9-bp exons in the COL4A5 gene. Pediatr Nephrol 16, 41–44 (2001). https://doi.org/10.1007/s004670000462

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  • DOI: https://doi.org/10.1007/s004670000462

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