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Pediatric Nephrology

, Volume 16, Issue 1, pp 51–56 | Cite as

Human T-cell lymphotropic virus-1-associated renal disease in Jamaican children

  • M. E. Y. Miller
  • Dipak J. Shah
  • Everard N. Barton
  • Andrea H. E. Gray
  • Curtis B. Yeates
Clinical Nephrology / Original Article

Abstract 

This report documents the clinicopathological features in two Jamaican children who presented with infective dermatitis, glomerulonephritis, renal failure and human T-cell lymphotropic virus (HTLV-1) seropositivity. Severe hypertension with hypertensive encephalopathy was the most impressive clinical feature. Histological findings from renal biopsy specimens in both cases revealed significant glomerulosclerosis with fibrosis, chronic inflammatory cell infiltrates in the interstitium, and arteriolar hypertensive changes. Membranoproliferative glomerulonephritis (MPGN) was demonstrable in case 1 and marked focal glomerulosclerosis in case 2. Case 1 developed end stage renal failure and died within 3 years of diagnosis. Case 2 remains hypertensive and in chronic renal failure. Although a causal relationship between HTLV-1 infection and renal disease cannot be proven by these two cases, it appears that renal involvement in children with HTLV-1 infection is severe, with the potential for chronic renal failure and malignant hypertension. HTLV-1 nephropathy should be suspected in children with infective dermatitis and renal disease.

Keywords HTLV-1 Renal failure Hypertension Infective dermatitis 

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Copyright information

© IPNA - International Pediatric Nephrology Association New York, USA 2001

Authors and Affiliations

  • M. E. Y. Miller
    • 1
  • Dipak J. Shah
    • 2
  • Everard N. Barton
    • 3
  • Andrea H. E. Gray
    • 4
  • Curtis B. Yeates
    • 5
  1. 1.Section of Child Health, University of the West Indies, Mona, Kingston 7, Jamaica, West Indies e-mail: maorellim@cwjamaica.com Tel.: +1-876-9310460, Fax: +1-876-9271446JM
  2. 2.Department of Pathology, University of the West Indies, Mona, Kingston 7, Jamaica, West IndiesJM
  3. 3.Department of Medicine, University of the West Indies, Mona, Kingston 7, Jamaica, West IndiesJM
  4. 4.Department of Paediatrics, Cornwall Regional Hospital, Montego Bay, Jamaica, West IndiesJM
  5. 5.Department of Paediatrics, Cornwall Regional Hospital, Montego Bay, Jamaica, West IndiesJM

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