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Unexpected finding in kidney biopsy of a child with nephrotic proteinuria: Answers

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References

  1. Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J, Grody WW, Hegde M, Lyon E, Spector E, Voelkerding K, Rehm HL (2015) Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med 17:405–424. https://doi.org/10.1038/gim.2015.30

    Article  Google Scholar 

  2. Jin YY, Huang LM, Quan XF, Mao JH (2021) Dent disease: classification, heterogeneity and diagnosis. World J Pediatr 17:52–57. https://doi.org/10.1007/s12519-020-00357-1

    Article  Google Scholar 

  3. van Berkel Y, Ludwig M, van Wijk JAE, Bökenkamp A (2017) Proteinuria in Dent disease: a review of the literature. Pediatr Nephrol 32:1851–1859. https://doi.org/10.1007/s00467-016-3499-x

    Article  Google Scholar 

  4. Li F, Yue Z, Xu T, Chen M, Zhong L, Liu T, Jing X, Deng J, Hu B, Liu Y, Wang H, Lai KN, Sun L, Liu J, Maxwell PH, Wang Y (2016) Dent disease in Chinese children and findings from heterozygous mothers: phenotypic heterogeneity, fetal growth, and 10 novel mutations. J Pediatr 174:204-210.e1. https://doi.org/10.1016/j.jpeds.2016.04.007

    Article  Google Scholar 

  5. Claverie-Martín F, Ramos-Trujillo E, García-Nieto V (2011) Dent’s disease: clinical features and molecular basis. Pediatr Nephrol 26:693–704. https://doi.org/10.1007/s00467-010-1657-0

    Article  Google Scholar 

  6. Sekine T, Komoda F, Miura K, Takita J, Shimadzu M, Matsuyama T, Ashida A, Igarashi T (2014) Japanese Dent disease has a wider clinical spectrum than Dent disease in Europe/USA: genetic and clinical studies of 86 unrelated patients with low-molecular-weight proteinuria. Nephrol Dial Transplant 29:376–384. https://doi.org/10.1093/ndt/gft394

    Article  CAS  Google Scholar 

  7. Gianesello L, Del Prete D, Anglani F, Calò LA (2021) Genetics and phenotypic heterogeneity of Dent disease: the dark side of the moon. Hum Genet 140:401–421. https://doi.org/10.1007/s00439-020-02219-2

    Article  Google Scholar 

  8. Blanchard A, Curis E, Guyon-Roger T, Kahila D, Treard C, Baudouin V, Bérard E, Champion G, Cochat P, Dubourg J, de la Faille R, Devuyst O, Deschenes G, Fischbach M, Harambat J, Houillier P, Karras A, Knebelmann B, Lavocat MP, Loirat C, Merieau E, Niaudet P, Nobili F, Novo R, Salomon R, Ulinski T, Jeunemaître X, Vargas-Poussou R (2016) Observations of a large Dent disease cohort. Kidney Int 90:430–439. https://doi.org/10.1016/j.kint.2016.04.022

    Article  Google Scholar 

  9. Frishberg Y, Dinour D, Belostotsky R, Becker-Cohen R, Rinat C, Feinstein S, Navon-Elkan P, Ben-Shalom E (2009) Dent’s disease manifesting as focal glomerulosclerosis: is it the tip of the iceberg? Pediatr Nephrol 24:2369–2373. https://doi.org/10.1007/s00467-009-1299-2

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatric Nephrology, Dokuz Eylül University Medical Faculty, Balçova, Izmir, 35340, Turkey

    Meral Torun Bayram, Gizem Yildiz, Alper Soylu & Salih Kavukcu

  2. Department of Medical Genetics, Dokuz Eylül University Medical Faculty, Izmir, Turkey

    Ahmet Okay Cağlayan & Ayfer Ulgenalp

  3. Department of Pathology, Dokuz Eylül University Medical Faculty, Izmir, Turkey

    Sadiye Mehtat Unlu

Authors
  1. Meral Torun Bayram
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  2. Gizem Yildiz
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  5. Sadiye Mehtat Unlu
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  6. Alper Soylu
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  7. Salih Kavukcu
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Correspondence to Meral Torun Bayram.

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This refers to the article that can be found at http://dx.doi.org/10.1007/s00467-022-05614-1.

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Bayram, M.T., Yildiz, G., Cağlayan, A.O. et al. Unexpected finding in kidney biopsy of a child with nephrotic proteinuria: Answers. Pediatr Nephrol 38, 115–117 (2023). https://doi.org/10.1007/s00467-022-05615-0

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  • DOI: https://doi.org/10.1007/s00467-022-05615-0

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